180476-30-6 Usage
Uses
Used in Organic Synthesis:
1,2,3-Tri-O-benzoyl-α-L-fucopyranose, Trichloroacetimidate is used as a synthetic intermediate for the preparation of various complex organic molecules. Its unique structure allows for selective reactions and functional group manipulations, making it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Carbohydrate Chemistry:
In the field of carbohydrate chemistry, 1,2,3-Tri-O-benzoyl-α-L-fucopyranose, Trichloroacetimidate serves as a key intermediate for the synthesis of oligosaccharides, glycoconjugates, and other carbohydrate-based compounds. Its trichloroacetimidate group enables efficient glycosylation reactions, facilitating the formation of glycosidic bonds and the assembly of complex carbohydrate structures.
Used in Medicinal Chemistry:
1,2,3-Tri-O-benzoyl-α-L-fucopyranose, Trichloroacetimidate is also utilized in medicinal chemistry for the development of glycomimetic drugs and probes. Its ability to mimic the structure and function of natural carbohydrates allows for the design of novel therapeutic agents targeting carbohydrate-binding proteins and enzymes, which play crucial roles in various diseases and biological processes.
Used in Material Science:
In material science, 1,2,3-Tri-O-benzoyl-α-L-fucopyranose, Trichloroacetimidate can be employed in the synthesis of carbohydrate-based polymers, dendrimers, and other advanced materials. These materials exhibit unique properties, such as self-assembly, molecular recognition, and stimuli-responsive behavior, making them suitable for applications in drug delivery, sensors, and nanotechnology.
Check Digit Verification of cas no
The CAS Registry Mumber 180476-30-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,0,4,7 and 6 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 180476-30:
(8*1)+(7*8)+(6*0)+(5*4)+(4*7)+(3*6)+(2*3)+(1*0)=136
136 % 10 = 6
So 180476-30-6 is a valid CAS Registry Number.
180476-30-6Relevant articles and documents
On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin
Medve, Laura,Achilli, Silvia,Serna, Sonia,Zuccotto, Fabio,Varga, Norbert,Thépaut, Michel,Civera, Monica,Vivès, Corinne,Fieschi, Franck,Reichardt, Niels,Bernardi, Anna
, p. 14448 - 14460 (2018/09/21)
A library of mannose- and fucose-based glycomimetics was synthesized and screened in a microarray format against a set of C-type lectin receptors (CLRs) that included DC-SIGN, DC-SIGNR, langerin, and dectin-2. Glycomimetic ligands able to interact with dectin-2 were identified for the first time. Comparative analysis of binding profiles allowed their selectivity against other CLRs to be probed.
Synthesis of guanosine 5′-(β-L-fucopyranosyl)-diphosphate revisited
Heskamp,Broxterman,Van Der Marel,Van Boom
, p. 611 - 622 (2007/10/03)
It will be demonstrated that a successful synthesis of β-L-fucopyranose-1-phosphate (2), a key intermediate in the preparation of guanosine 5′-(β-L-fucopyranose)-diphosphate (1), strongly depends on the nature of the acyl protecting groups for the non-anomeric hydroxyl functions. Thus, the perbenzoylated, instead of peracetylated, α-L-fucopyranosyl trichloroacetimidate (11) or the corresponding ethyl β-thiofucopyranoside proved to be a convenient starting compound for the preparation of 2. Further, condensation of N,N'-dicyclohexyl-4-morpholinecarboxamidinium guanosine 5′-morpholidophosphate with excess 2 gave the title compound without concomitant formation of bisguanosine-5′-diphosphate (16).
