- New Flavonoids from Artemisia frigida
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New flavonoids were isolated from the aerial part of Artemisia frigida Willd. (Asteraceae). Their structures were elucidated using UV, IR, and NMR spectroscopy and mass spectrometry as chrysoeriol-7-O-(2′′-Oacetyl)-β-D-glucopyranoside (2′′-O-acetylthermop
- Olennikov
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- 5, 7-dihydroxy-6-production of polymethoxyflavones
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PROBLEM TO BE SOLVED: To provide an efficient production method of 5,7-dihydroxy-6-methoxyflavones in a short step. SOLUTION: The production method of 5,7-dihydroxy-6-methoxyflavones includes a step of demethylating 5,6,7-trimethoxy-8-acylflavones expressed by general formula (II). In the formula, n represents an integer of 0 to 5; R2represents a hydroxyl group or the like and when n is 2 or more, a plurality of R2may be the same or different from each other; and R3represents a 1-4C straight-chain or branched alkyl group or the like. COPYRIGHT: (C)2012,JPOandINPIT
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- Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production
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A number of oroxylin A analogs were prepared and evaluated for their inhibitory activities against iNOS-mediated nitric oxide (NO) production from LPS-stimulated BV2 cells. The analogs were synthesized from purchased 2′-hydroxy-4,5,6-trimethoxyacetophenone and aldehydes in 3 steps. Among the tested compounds, several analogs (3b, 3c, 3d, 3f) exhibited strong inhibitory activities. Especially, the analog with 4-nitrophenyl group (3b) showed stronger inhibitory activity (IC50 = 4.73 μM) than that of wogonin (IC50 = 7.80 μM).
- Pham, Tuan-Ahn. N.,Che, Haiyan,Phan, Phuong-Thuy T.,Lee, Jae-Won,Kim, Sung-Soo,Park, Haeil
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p. 2534 - 2535
(2012/05/05)
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