51145-80-3Relevant academic research and scientific papers
Identification and Quantification of Both Methylation and Demethylation Biotransformation Metabolites of 5-Demethylsinensetin in Rats
Wang, Xiaoqi,Li, Dongli,Cao, Yong,Ho, Chi-Tang,Huang, Qingrong
, p. 3162 - 3171 (2022/03/16)
5-Demethylated polymethoxyflavones (5-OH PMFs) are the most unique monodemethylated PMFs with relatively low polarities and are proved to possess better anticancer and anti-inflammatory effects than their respective permethoxylated ones. However, their de
Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production
Pham, Tuan-Ahn. N.,Che, Haiyan,Phan, Phuong-Thuy T.,Lee, Jae-Won,Kim, Sung-Soo,Park, Haeil
scheme or table, p. 2534 - 2535 (2012/05/05)
A number of oroxylin A analogs were prepared and evaluated for their inhibitory activities against iNOS-mediated nitric oxide (NO) production from LPS-stimulated BV2 cells. The analogs were synthesized from purchased 2′-hydroxy-4,5,6-trimethoxyacetophenone and aldehydes in 3 steps. Among the tested compounds, several analogs (3b, 3c, 3d, 3f) exhibited strong inhibitory activities. Especially, the analog with 4-nitrophenyl group (3b) showed stronger inhibitory activity (IC50 = 4.73 μM) than that of wogonin (IC50 = 7.80 μM).
