2306-27-6 Usage
Description
SINENSETIN is a pentamethoxyflavone, which is a type of flavone molecule substituted by methoxy groups at positions 5, 6, 7, 3', and 4'. It is a primary reference substance with assigned absolute purity, taking into account chromatographic purity, water, residual solvents, and inorganic impurities. The exact purity value can be found on the certificate provided by PhytoLab GmbH & Co. KG.
Uses
Used in Pharmaceutical Industry:
SINENSETIN is used as an antiangiogenesis agent for inhibiting the formation of new blood vessels, which is crucial in controlling the growth and spread of cancer cells.
Used in Healthcare Industry:
SINENSETIN is used as an antidiabetic agent, potentially helping in the management and treatment of diabetes by regulating blood sugar levels.
Used in Antifungal Applications:
SINENSETIN is used as an antifungal agent, effective against various fungal infections due to its ability to inhibit fungal growth and activity.
Used in Antihistamine Applications:
SINENSETIN is used as an antihistamine agent, helping to alleviate symptoms caused by histamine release, such as allergies and inflammation.
Used in Cell Differentiation:
SINENSETIN is used to induce cell differentiation, which can be beneficial in the treatment of certain diseases and conditions where abnormal cell growth occurs.
Used in Inhibition of Linoleic Acid Oxidation:
SINENSETIN is used to inhibit linoleic acid oxidation, which can help prevent the formation of harmful free radicals and maintain overall health.
Used in Inhibition of White Blood Cells in Human Zona Protein Interleukin-1β Induced Expression of Tissue Factor:
SINENSETIN is used to inhibit the expression of tissue factor in white blood cells induced by human zona protein Interleukin-1β, which can be relevant in the context of immune response and inflammation.
Biochem/physiol Actions
Sinensetin is a citris flavonoid with anti-inflammatory and anti-proliferative activity. It has also been shown to enhance adipogenesis and lipolysis.
Check Digit Verification of cas no
The CAS Registry Mumber 2306-27-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,0 and 6 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2306-27:
(6*2)+(5*3)+(4*0)+(3*6)+(2*2)+(1*7)=56
56 % 10 = 6
So 2306-27-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H20O7/c1-22-13-7-6-11(8-15(13)23-2)14-9-12(21)18-16(27-14)10-17(24-3)19(25-4)20(18)26-5/h6-10H,1-5H3
2306-27-6Relevant articles and documents
5,6-DIMETHOXY-7,3',4',-TRIHYDROXYFLAVONE FROM ANISOMELES OVATA
Rao, L. Jagan Mohan,Kumari, G. N. Krishna,Rao, N. S. Prakasa
, p. 1522 (1983)
5,6-Dimethoxy-7,3',4'-trihydroxyflavone was isolated from the aerial parts of Anisomeles ovata and characterized by both physical and chemical methods.Key Word Index - Anisomeles ovata; Labiatae; flavone; 5,6-dimethoxy-7,3',4'-trihydroxyflavone.
Synthesis and anti-proliferative activities of 5,6,7-trimethoxyflavones and their derivatives
Li, Wei,Liu, Kexiong,Su, Liang,Wang, Qiuan
supporting information, (2021/08/12)
A series of 5,6,7-trimethoxyflavones 1a-1g and their derivatives 2a-2g, 3a-3d, 4 and 5, including the natural products 5,6,7-trimethoxy-4’-hydroxyflavone (1a), 5,6,7,3’,4’ -pentamethoxyflavone (sinensetin, 1 b), 5,6,7-trimethoxy-3’,4’-methyl enedioxy flavone (1c), 5,6,7,3’-tetramethoxy-4,5’-methylenedioxyflavone (1e), 5,6,7, 3’,4’,5’-hextamethoxyflavone (1 g), 5-hydroxy-3,4,2’,3’,4’-pentamethoxy chal-cone (2 b), 5,4’-dihydroxy-6,7-dimethoxy flavone (cirsimaritin, 3a) and 5-hydroxy-6,7,3’, 4’-tetramethoxyflavone (5-demethylsinensetin, 3 b), 3,5,6,7,3’,4’-hexamethoxyflavone (3-methoxysinensetin, 4) and 5’-hydroxy-3,6,7,3’,4’-pentamethoxyflavone (5) were synthesized. Their anti-proliferative activity in?vitro was evaluated against a panel of four human cancer cell lines (Aspc-1, HCT-116, HepG-2 and SUN-5) by the CTG assay. The results showed that most of the synthetic compounds exhibited moderate to high anti-proliferative activities. In particular, compound 3c possess IC50 (5.30 μM) values below 10 μM against Aspc-1 cells and are worthy of further investigation.
Use of flavone and flavanone derivatives in preparation of sedative and hypnotic drugs
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Page/Page column 48; 49; 50; 51, (2017/07/01)
Disclosed is a use of flavones derivatives and flavanone derivatives in preparation of sedative and hypnotic drugs.
USE OF FLAVONE AND FLAVANONE DERIVATIVES IN PREPARATION OF SEDATIVE AND HYPNOTIC DRUGS
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Paragraph 0223; 0235, (2015/07/22)
Disclosed is a use of flavones derivatives and flavanone derivatives in preparation of sedative and hypnotic drugs.
