A highly efficient asymmetric synthesis of β-aminophosphonic acids via addition of α-phosphonate carbanions to chiral, enantiopure sulfinimines
Addition of α-phosphonate carbanions to (S)-sulfinimines 1 affords N-sulfinyl β-aminophosphonates 2 in a diastereoisomeric ratio from 5:1 to 10:1; the major diastereoisomers of 2, after separation, are converted to the corresponding β-aminophosphonates 3
Mikolajczyk, Marian,Lyzwa, Piotr,Drabowicz, Jozef,Wieczorek, Michal W.,Blaszczyk, Jaroslaw
A New Asymmetric Synthesis of β-Aminophosphonic Acids
Addition of α-phosphonate carbanions to (S)-sulfinimines 2 gives N-sulfinyl-β-aminophosphonates 3 with a high diastereoselectivity (up to 10:1).The major diastereometer of 3 (R=Ph) was converted into (+)-(R)-β-amino-β-phenylethanephosphonic acid 5. - Keyw
Mikolajczyk, Marian,Lyzwa, Piotr,Drabowicz, Jozef
p. 357 - 358
(2007/10/03)
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