Synthesis of β-aminosulfonopeptides activated through selective N-nitration of a taurine amide unit
β-Sulfonopeptides bearing a taurine in place of a penultimate amino acid unit were designed and synthesized as inhibitors of D-alanyl-D-alanine transpeptidase; N-nitration of the sulfonamide bond in the presence of multiple carboxamide groups was selectively accomplished through use of NO2BF4.