Synthesis of β-aminosulfonopeptides activated through selective N-nitration of a taurine amide unit

Article abstract of DOI:10.1016/0040-4039(96)00903-3

β-Sulfonopeptides bearing a taurine in place of a penultimate amino acid unit were designed and synthesized as inhibitors of D-alanyl-D-alanine transpeptidase; N-nitration of the sulfonamide bond in the presence of multiple carboxamide groups was selectively accomplished through use of NO₂BF₄.