181931-42-0

Basic information

• Product Name: 1-(4-fluorophenyl)-2-mercaptoethanone
• CAS NO: 181931-42-0
• Molecular Weight: 170.207
• Mol File: 181931-42-0.mol

Chemical Properties

• CAS DataBase Reference: 1-(4-fluorophenyl)-2-mercaptoethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorophenyl)-2-mercaptoethanone(181931-42-0)
• EPA Substance Registry System: 1-(4-fluorophenyl)-2-mercaptoethanone(181931-42-0)

Safety Data

• Hazardous Substances Data: 181931-42-0(Hazardous Substances Data)

Upstream product

• 181931-41-9 S-acetyl-2-mercapto-4’-fluoroacetophenone 
• 456-04-2 2-Chloro-4'-fluoroacetophenone 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 403-42-9 1-(4-fluorophenyl)ethanone 

Downstream Products

• 181931-43-1 4-(4-Fluoro-phenyl)-2-isopropyl-2,5-dihydro-thiophene-3-carboxylic acid ethyl ester 

Relevant articles and documents

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Synthesis of some highly functionalized thiophene-3-carboxylates and alcohols

Highly functionalized thiophenes are prepared by two methods. The first uses a lithium-halogen exchange reaction on a trisubstituted 5-bromothiophene 25 to generate the corresponding 5-lithiothiophene 26 which is then reacted with either dimethylformainide or formaldehyde to give the 5-formyl 28 or 5-hydroxymethylthiophene derivative 31 in good yields. These are further transformed to other tetrasubstituted thiophenes. The second method assembles the thiophene ring from three components: a benzyl mercaptan, an aldehyde, and a vinylphosphonate 10. Thus, the benzyl mercaptan is dilithiated then reacted with an appropriate aldehyde to afford a 2-mercapto-2-phenylethanol derivative 37. Michael addition of 37 to 10 followed by oxidation of the hydroxyl group furnishes ketophosphonate 39. An intramolecular Wittig-type reaction produces the thiophene skeleton.