181931-41-9

Upstream product

• 456-04-2 2-Chloro-4'-fluoroacetophenone 
• 10387-40-3 potassium thioacetate 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 507-09-5 tiolacetic acid 
• 403-42-9 1-(4-fluorophenyl)ethanone 

Downstream Products

• 181931-43-1 4-(4-Fluoro-phenyl)-2-isopropyl-2,5-dihydro-thiophene-3-carboxylic acid ethyl ester 
• 181931-42-0 mercapto-1-(4’-fluorophenyl)ethanone 
• 181931-45-3 1-(4-Fluoro-phenyl)-2-mercapto-ethanol 
• 181931-48-6 [4-(4-Fluoro-phenyl)-2-isopropyl-thiophen-3-yl]-methanol 
• 181931-44-2 4-(4-Fluoro-phenyl)-2-isopropyl-thiophene-3-carboxylic acid ethyl ester 
• 181931-54-4 4-(4-Fluoro-phenyl)-5-hydroxymethyl-2-isopropyl-thiophene-3-carboxylic acid ethyl ester 
• 181931-49-7 5-Bromo-4-(4-fluoro-phenyl)-2-isopropyl-thiophene-3-carboxylic acid ethyl ester 
• 181931-51-1 4-(4-Fluoro-phenyl)-5-formyl-2-isopropyl-thiophene-3-carboxylic acid ethyl ester 
• 181931-52-2 5-Dimethylaminomethyl-4-(4-fluoro-phenyl)-2-isopropyl-thiophene-3-carboxylic acid ethyl ester 
• 181931-57-7 4-(4-Fluoro-phenyl)-2-isopropyl-5-(2-methoxy-ethoxymethyl)-thiophene-3-carboxylic acid ethyl ester 
• 181931-47-5 2-(Diethoxy-phosphoryl)-3-[2-(4-fluoro-phenyl)-2-oxo-ethylsulfanyl]-4-methyl-pentanoic acid ethyl ester 
• 181931-46-4 2-(Diethoxy-phosphoryl)-3-[2-(4-fluoro-phenyl)-2-hydroxy-ethylsulfanyl]-4-methyl-pentanoic acid ethyl ester 
• 181931-55-5 5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(4-fluoro-phenyl)-2-isopropyl-thiophene-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Intermolecular Phosphite-Mediated Radical Desulfurative Alkene Alkylation Using Thiols

We report herein the development of a S atom transfer process using triethyl phosphite as the S atom acceptor that allows thiols to serve as precursors of C-centered radicals. A range of functionalized and electronically unbiased alkenes including those containing common heteroatom-based functional groups readily participate in this reductive coupling. This process is driven by the exchange of relatively weak S-H and C-S bonds of aliphatic thiols for C-H, C-C, and S-P bonds of the products formed.

Br?nsted-base-catalyzed remote cascade reactivity of 2,4-dienones-asymmetric synthesis of tetrahydrothiophenes

This study demonstrates that the remote cascade functionalization of 2,4-dienones can be realized by employing Br?nsted base catalysis. The developed cascade involving 1,6-addition followed by the intramolecular aldol reaction provides a straightforward a

BIPHENYLAZETIDINONE CHOLESTEROL ABSORPTION INHIBITORS

The invention relates to a chemical genus of 4-biphenyl-1-phenylazetidin-2-ones useful in the treatment of hypercholesterolemia and other disorders. The compounds have the general formula (I). Pharmaceutical compositions and methods for treating cholesterol- and lipid-associated diseases are also disclosed.

Synthesis of some highly functionalized thiophene-3-carboxylates and alcohols

Highly functionalized thiophenes are prepared by two methods. The first uses a lithium-halogen exchange reaction on a trisubstituted 5-bromothiophene 25 to generate the corresponding 5-lithiothiophene 26 which is then reacted with either dimethylformainide or formaldehyde to give the 5-formyl 28 or 5-hydroxymethylthiophene derivative 31 in good yields. These are further transformed to other tetrasubstituted thiophenes. The second method assembles the thiophene ring from three components: a benzyl mercaptan, an aldehyde, and a vinylphosphonate 10. Thus, the benzyl mercaptan is dilithiated then reacted with an appropriate aldehyde to afford a 2-mercapto-2-phenylethanol derivative 37. Michael addition of 37 to 10 followed by oxidation of the hydroxyl group furnishes ketophosphonate 39. An intramolecular Wittig-type reaction produces the thiophene skeleton.