- Recycling method of 1-phenyl-5-hydroxytetrazole
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The invention discloses a recycling method of 1-phenyl-5-hydroxytetrazole, and belongs to the technical field of medicinal chemistry. The preparation method comprises the following steps: a byproduct1-phenyl-5-hydroxytetrazole generated in preparation process of a rosuvastatin calcium intermediate is converted into 1-phenyl-5-mercaptotetrazole; and meanwhile, the 1-phenyl-5-mercaptotetrazole is further used for preparing a rosuvastatin calcium intermediate or rosuvastatin calcium. According to the method disclosed by the invention, reasonable recycling of the byproduct 1-phenyl-5-hydroxytetrazole is realized, the raw materials are fully utilized, the production cost of rosuvastatin calcium and the intermediate thereof is reduced, and the emission of three wastes is reduced.
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Paragraph 0062-0063; 0068; 0070-0073
(2020/01/12)
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- An efficient synthesis of 1-substituted 5-bromo-1 H -tetrazoles
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1-Substituted 1H-tetrazole-5-thiols were efficiently converted into the corresponding 1-substituted 5-bromo-1H-tetrazoles by treatment with zinc(II) bromide and 50% hydrogen peroxide or 36% peracetic acid at 70-80 °C. In most cases, the 5-bromotetrazole p
- Myznikov, Leonid,Dmitrieva, Ulyana,Artamonova, Tatiana,Roh, Jaroslav,Hrabalek, Alexandr,Zevatskii, Yuri
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p. 2029 - 2033
(2013/07/26)
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