182438-97-7

Basic information

• Product Name: 9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)-
• Synonyms: 9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)-
• CAS NO: 182438-97-7
• Molecular Formula: C₁₈H₁₇BrO₂
• Molecular Weight: 345.23038
• EINECS: -0
• Mol File: 182438-97-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)-(182438-97-7)
• EPA Substance Registry System: 9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)-(182438-97-7)

Safety Data

• Hazardous Substances Data: 182438-97-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)is used as a building block in organic synthesis for creating a variety of complex organic molecules. Its unique structure allows for the formation of new chemical bonds and the synthesis of novel compounds with potential applications in various fields.
Used in Chemical Research:
In the realm of chemical research, 9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)serves as a valuable compound for studying reaction mechanisms, exploring new synthetic routes, and understanding the properties of fluorene-based materials.
Used in Pharmaceutical Development:
9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)is used as a potential candidate in pharmaceutical development due to its unique structure and properties. It may contribute to the design of new drugs with specific therapeutic effects, particularly in areas where its chemical features can be exploited for targeted drug delivery or enhanced bioactivity.
Used in Agrochemicals:
In agrochemical applications, 9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)may be utilized in the development of new pesticides, herbicides, or other agricultural chemicals. Its unique structure could provide novel modes of action or improved efficacy in managing pests and diseases in agriculture.
Used in Materials Science:
9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)is used in materials science for the development of new materials with specific properties. Its incorporation into polymers or other materials could lead to advancements in areas such as conductivity, stability, or responsiveness to environmental stimuli.
Used in Organic Electronics:
In the field of organic electronics, 9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)may be employed as a component in the design and fabrication of organic electronic devices, such as organic light-emitting diodes (OLEDs), organic solar cells, or organic field-effect transistors (OFETs), due to its electronic properties and processability.
Used as a Precursor in Chemical Synthesis:
9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)is used as a precursor to various functionalized fluorene derivatives in chemical synthesis. Its unique structure allows for further chemical modifications, leading to a wide range of fluorene-based compounds with diverse applications in various industries.

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 1989-33-9 9H-fluorene-9-carboxylic acid 
• 62168-25-6 1,1-dibromobutane 

Downstream Products

• 182438-98-8 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoro-ethyl)-amide 
• 182431-12-5 9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide 
• 202914-84-9 N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4’-(trifluoromethyl)[1,1‘-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9H-fluorene-9-carboxamide methanesulfonate 
• 223559-49-7 (2-oxo-2-{4-[9-(2,2,2-trifluoro-ethylcarbamoyl)-9H-fluoren-9-yl]-butyl}-2λ⁵-[1,3,2]dioxaphosphinan-5-yl)-carbamic acid benzyl ester 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF LOMITAPIDE

The present invention relates to a process for preparing Lomitapide or its pharmaceutically acceptable salt thereof having high purity with acceptable levels of impurities.

AMORPHOUS FORM OF LOMITAPIDE MESYLATE

Provided is novel amorphous form of lomitapide mesylate salt and process for preparation thereof.

Method for synthesizing triglyceride transfer protease inhibitor

The invention discloses a method for synthesizing the triglyceride transfer protease inhibitor Lomitapide. Specifically, based on improvement of an existing technique, the compounds 9-carboxyfluorene and 1,4-dibromobutane are used as raw materials, five-step reaction is conducted, and the defects of the prior art are overcome. Compared with the prior art, the method has the main advantage that column chromatography purification is avoided, and product purification is conducted with a recrystallization method which is economical and environment-friendly.

Substituted piperazine derivatives, the preparation thereof and their use as medicaments

The present invention relates to substituted piperazine derivatives of general formula wherein Ra, Rb, RcRf, Rgand m, n and X are defined as in claim 1, the isomers and salts thereof, particularly the

CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD

Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure (I) or (IA) or (IB) including pharmaceutically acceptable salts thereof or prodrug esters thereof, wherein q is 0,1 or 2; R is H, alkyl, aryl or halogen; A is (1) a bond; (2) -O-; or (3) (i); B is: (ii) or (iii) or (iv) or (v) (wherein (a = 2, 3 or 4)) or (vi) or (vii) or (viii); and wherein L, L, R, R, R, R, R, R, R, R, R, X, (ix), (x) and (xi) are as defined herein.

5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP

5-Carboxamido-1,3,2-dioxaphosphorinanes have been identified as potent inhibitors of microsomal triglyceride-transfer protein. The 1,3,2- dioxaphosphorine functionality acted as a neutral and stable replacement for piperidine and piperidine N-oxide.

Substituted piperazine derivatives, the preparation thereofand their use as medicaments

The present invention relates to substituted piperazine derivatives of general formula , (I wherein Ra, Rb, Rc, Rf, Rg, X, m and n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyceride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.

Substituted piperazine derivatives as mtp inhibitors

The present invention relates to substituted piperazine derivatives of general formula wherein Ra to Rc, Ya, Yb, X and n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyceride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.

A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors

A series of benzimidazole-based analogues of the potent MTP inhibitor BMS-201038 were discovered. Incorporation of an unsubstituted benzimidazole moiety in place of a piperidine group afforded potent inhibitors of MTP in vitro which were weakly active in vivo. Appropriate substitution on the benzimidazole ring, especially with small alkyl groups, led to dramatic increases in potency, both in a cellular assay of apoB secretion and especially in animal models of cholesterol lowering. The most potent in this series, 3g (BMS-212122), was significantly more potent than BMS-201038 in reducing plasma lipids (cholesterol, VLDL/LDL, TG) in both hamsters and cynomolgus monkeys.