- Nano indium oxide-catalyzed domino reaction for the synthesis of N-alkoxylated benzimidazoles
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A convenient method has been developed for the selective synthesis of N-alkoxylated benzimidazole derivatives by the cyclocondensation reaction of simple ortho-phenylenediamine, formaldehyde and alcohols in presence of indium oxide nanoparticles as catalyst. The alcohol acts as reactant as well as solvent in this reaction. No other solvents or additives have been used for this reaction. The catalyst can be reused several times without significant loss of catalytic activity. A probable reaction mechanism has been proposed based on some control experiments.
- Samanta, Satyajit,Mahato, Sachinta,Chatterjee, Rana,Santra, Sougata,Zyryanov, Grigory V.,Majee, Adinath
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supporting information
(2020/07/20)
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- Novel access to 1-substituted-benzimidazoles via benzotriazole-mediated synthesis
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A one-pot good-yielding synthesis of 1-(alcoxymethyl)-1H-benzimidazoles and 1-((1H-benzimidazol-1-yl)methyl)-1H-benzotriazole from N1,N2-bis((1H-benzotriazol-1-yl)methyl)benzene-1,2 -diamine (3) and alcohols is described. The synthesis of 3 from macrocyclic aminal 6H,13H-5:12,7:14-dimethanedibenzo-[d,i][1,3,6,8]tetraazecine (DMDBTA, 1) and benzotriazole is also described. Both these methods are simple, isolation of the products from the reaction mixtures is easy, and the yields are good.
- Rivera, Augusto,Maldonado, Mauricio,Ríos-Motta, Jaime,Navarro, Miguel Angel,González-Salas, Diego
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experimental part
p. 102 - 104
(2010/03/03)
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