183298-93-3

Basic information

• Product Name: 1,2,3-Thiadiazole-5-carboxylicacid,4-methyl-,methylester(9CI)
• Synonyms: 1,2,3-Thiadiazole-5-carboxylicacid,4-methyl-,methylester(9CI);methyl 4-methyl-1,2,3-thiadiazole-5-carboxylate;methyl 4-methylthiadiazole-5-carboxylate
• CAS NO: 183298-93-3
• Molecular Formula: C₅H₆N₂O₂S
• Molecular Weight: 158.18
• Product Categories: CARBOXYLICESTER
• Mol File: 183298-93-3.mol

Chemical Properties

• Boiling Point: 224.7°C at 760 mmHg
• Flash Point: 89.7°C
• Appearance: /
• Density: 1.323g/cm³
• Vapor Pressure: 0.0897mmHg at 25°C
• Refractive Index: 1.538
• CAS DataBase Reference: 1,2,3-Thiadiazole-5-carboxylicacid,4-methyl-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3-Thiadiazole-5-carboxylicacid,4-methyl-,methylester(9CI)(183298-93-3)
• EPA Substance Registry System: 1,2,3-Thiadiazole-5-carboxylicacid,4-methyl-,methylester(9CI)(183298-93-3)

Safety Data

• Hazardous Substances Data: 183298-93-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,2,3-Thiadiazole-5-carboxylic acid, 4-methyl-, methyl ester (9CI) is used as a potential pharmaceutical candidate for its structural properties and potential biological activities. Its heterocyclic nature and functional groups may contribute to the development of new drugs with therapeutic benefits.
Used in Organic Synthesis:
1,2,3-Thiadiazole-5-carboxylic acid, 4-methyl-, methyl ester (9CI) can be used as a building block for the synthesis of various organic compounds. Its unique structure and functional groups may facilitate the creation of novel molecules with specific properties and applications in different fields.
However, it is important to note that further research and evaluation are necessary to determine the specific uses, potential benefits, and safety profile of this compound. The exploration of its applications in different industries and the development of efficient production methods will be crucial for its successful integration into various fields.

InChI:InChI=1/C5H6N2O2S/c1-3-4(5(8)9-2)10-7-6-3/h1-2H3

Upstream product

• 67-56-1 methanol 
• 18212-21-0 4-methyl-[1,2,3]thiadiazole-5-carboxylic acid 

Downstream Products

• 18212-21-0 4-methyl-[1,2,3]thiadiazole-5-carboxylic acid 
• 163008-86-4 5-hydroxymethyl-4-methyl-1,2,3-thiadiazole 

Relevant articles and documents

Efficient methyl esterification using methoxyl silica gel as a novel dehydrating reagent

Methoxyl silica gel was prepared readily by the treatment of silica chloride with methanol. By using methoxyl silica gel as a dehydrating agent, carboxylic acids reacted with methanol in the presence of a protonic acid such as 12-phosphotungstic acid afforded the corresponding methyl esters in excellent yields.

Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling non-regulated necrosis. This form of cell death can be induced in an array of cell types in apoptotic deficient conditions with death receptor family ligands. A series of [1,2,3]thiadiazole benzylamides was found to be potent necroptosis inhibitors (called necrostatins). A structure-activity relationship study revealed that small cyclic alkyl groups (i.e. cyclopropyl) and 2,6-dihalobenzylamides at the 4- and 5-positions of the [1,2,3]thiadiazole, respectively, were optimal. In addition, when a small alkyl group (i.e. methyl) was present on the benzylic position all the necroptosis inhibitory activity resided with the (S)-enantiomer. Finally, replacement of the [1,2,3]thiadiazole with a variety of thiophene derivatives was tolerated, although some erosion of potency was observed.

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A3 agonists, methods of using such A3 agonists and pharmaceutical compositions containing such A3 agonists. The A3 agonists are useful for the reduction of tissue damage resulting from tissue ischemia or hypoxia