163008-86-4

Basic information

• Product Name: 4-METHYL-1,2,3-THIADIAZOLE-5-METHANOL
• Synonyms: 4-METHYL-1,2,3-THIADIAZOLE-5-METHANOL;(4-Methyl-1,2,3-thiadiazol-5-yl)methanol;5-(Hydroxymethyl)-4-methyl-1,2,3-thiadiazole;(4-methyl-1,2,3-thiadiazol-5-yl)methanol(SALTDATA: FREE);(4-Methyl-1,2,3-thiadiazol-5-yl)
• CAS NO: 163008-86-4
• Molecular Formula: C₄H₆N₂OS
• Molecular Weight: 130.17
• Product Categories: Hydroxymethyl's;Oxadiazoles & Thiadiazoles;Oxadiazoles & Thiadiazoles
• Mol File: 163008-86-4.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 261.481 °C at 760 mmHg
• Flash Point: 111.94 °C
• Appearance: /
• Density: 1.364 g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.553
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-METHYL-1,2,3-THIADIAZOLE-5-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-1,2,3-THIADIAZOLE-5-METHANOL(163008-86-4)
• EPA Substance Registry System: 4-METHYL-1,2,3-THIADIAZOLE-5-METHANOL(163008-86-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 163008-86-4(Hazardous Substances Data)

Usage

General Description

4-Methyl-1,2,3-thiadiazole-5-methanol is a chemical compound with the molecular formula C4H6N2OS. It is a heterocyclic compound containing a thiadiazole ring with a methyl and hydroxyl group attached to it. 4-METHYL-1,2,3-THIADIAZOLE-5-METHANOL is often used in pharmaceutical and chemical research as a building block for the synthesis of various biologically active molecules and potential drug candidates. It may also have potential applications in the development of new materials and organic synthesis strategies. As a result, 4-Methyl-1,2,3-thiadiazole-5-methanol is of interest to researchers in the fields of medicinal chemistry, organic synthesis, and chemical biology.

InChI:InChI=1/C4H6N2OS/c1-3-4(2-7)8-6-5-3/h7H,2H2,1H3

Upstream product

• 183298-93-3 methyl 4-methyl-1,2,3-thiadiazole-5-carboxylate 
• 18212-20-9 4-methyl-1,2,3-thiadiazole-5-carboxylic acid ethyl ester 

Downstream Products

• 127108-66-1 4-methyl-1,2,3-thiadiazole-5-carbaldehyde 

Relevant articles and documents

Synthesis and biological evaluation of 4-methyl-1,2,3-thiadiazole-5-carboxaldehyde benzoyl hydrazone derivatives

To find new lead compounds with high biological activity, a series of novel 4-methyl-1,2,3-thiadiazole-5-carboxaldehyde benzoyl hydrazone derivatives were designed and synthesized. Their structures were confirmed by 1H NMR, 13C NMR, IR spectrum and elemental analysis. Preliminary bioassay indicated that the title compounds exhibited moderate to strong fungicidal activity against six fungi in vitro at 50?μg/mL. Moreover, some of the title compounds exhibited good curative activity against TMV in vivo at 500?μg/mL. The structure-activity relationship analysis of compounds against Valsa mali showed that compounds containing halogen at the para position on phenyl exhibited the best activity. Especially compound 8k showed broad spectrum fungicidal activities against Valsa mali, Botrytis cinerea, Pythium aphanidermatum, Rhizoctonia solani, Fusarium moniliforme and Alternaria solani with the EC50 values of 8.20, 24.42, 15.80, 40.53, 41.48, and 34.16?μg/mL, respectively.

1,2,3-thiadiazole-containing benzoyl hydrazone derivative as well as preparation method and application thereof

The invention belongs to the field of organic compound synthesis and particularly relates to a 1,2,3-thiadiazole-containing benzoyl hydrazone derivative as well as a preparation method and application thereof. The structure of the compound is shown by a f

Synthesis, crystal structure and herbicidal activity of novel 1,2,3-thiadiazole substituted 2-cyanoacrylates

A series of novel 2-cyanoacrylates containing the 1,2,3-thiadiazole ring moiety were synthesized and characterized by 1H NMR, 13C NMR, elemental analysis and, in one case, by X-ray crystallography. Most of these cyanoacrylates exhibi