183545-02-0Relevant articles and documents
Scalable Asymmetric Synthesis of the All Cis Triamino Cyclohexane Core of BMS-813160
La Cruz, Thomas E.,González-Bobes, Francisco,Eastgate, Martin D.,Sfouggatakis, Chris,Zheng, Bin,Kopp, Nathaniel,Xiao, Yi,Fan, Yu,Galindo, Kay A.,Pathirana, Charles,Galella, Michael A.
, p. 1996 - 2011 (2021/09/02)
BMS-813160 is a pharmaceutical entity currently in development at Bristol Myers Squibb. Its defining structural feature is a unique chiral all cis triamino cyclohexane core. Medicinal and process chemistry groups at BMS have previously published synthesis
An asymmetric synthesis (-)-epibatidine
Trost, Barry M.,Cook, Gregory R.
, p. 7485 - 7488 (2007/10/03)
A Pd catalyzed desymmetrization of cis-3,6-dibenzoyloxy-2-cyclohexene and a Pd catalyzed cross-coupling constitute key reactions in a synthesis of the non-opioid analgesic (-)-epibatidine.