18356-28-0

Basic information

• Product Name: Rolziracetam
• Synonyms: 1-Azabicyclo[3.3.0]octane-2,8-dione;7,7a-Dihydro-1H-pyrrolizine-3,5(2H,6H)-dione;CI-911;dihydro-1H-Pyrrolizine-3,5(2H,6H)-dione
• CAS NO: 18356-28-0
• Molecular Formula: C₇H₉NO₂
• Molecular Weight: 139.153
• Mol File: 18356-28-0.mol

Chemical Properties

• Boiling Point: 274.9°Cat760mmHg
• Flash Point: 130.5°C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 0.00526mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: Rolziracetam(CAS DataBase Reference)
• NIST Chemistry Reference: Rolziracetam(18356-28-0)
• EPA Substance Registry System: Rolziracetam(18356-28-0)

Safety Data

• Hazardous Substances Data: 18356-28-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Rolziracetam is used as a cognitive enhancer for its ability to improve memory, learning, and attention. It is considered for the treatment of various cognitive disorders, such as Alzheimer's disease and age-related cognitive decline.
Used in Neuroprotection:
Rolziracetam is used as a neuroprotective agent for its potential to treat neurodegenerative diseases. Clinical studies have suggested that this compound may possess neuroprotective properties, making it a promising candidate for the treatment and management of such conditions.

InChI:InChI=1/C7H9NO2/c9-6-3-1-5-2-4-7(10)8(5)6/h5H,1-4H2

Upstream product

• 502-50-1 4-Ketopimelic acid 
• 7766-83-8 dimethyl 4-nitro-1,7-heptanedioate 
• 67-56-1 methanol 
• 81980-11-2 methyl β-(5-oxo-2-pyrrolidyl)propionate 
• 117169-25-2 N-acetyl-5-oxo-2-pyrrolidine propanoic acid ethyl ester 
• 64-17-5 ethanol 
• 108-24-7 acetic anhydride 
• 98547-95-6 4-nitroheptanedinitrile 
• 7766-85-0 4-aminopimelic acid 
• 7766-86-1 3-(5-oxo-pyrrolidin-2-yl)-propionic acid 

Downstream Products

• 89317-07-7 5-<2-(carboethoxy)ethyl>pyrrolidin-2-one 
• 431988-79-3 5-(3-oxo-4-phenyl-butyl)-pyrrolidin-2-one 
• 29879-82-1 β-(2-oxo-5-pyrrolidinyl)-propiophenone 
• 643-20-9 pyrrolizidine 
• 7766-86-1 3-(5-oxo-pyrrolidin-2-yl)-propionic acid 
• 117155-71-2 N-acetyl-5-oxo-2-pyrrolidine propanoic acid menthyl ester 
• 89317-16-8 5-oxo-N-α-methylbenzyl-2-pyrrolidinepropanoic acid amide 
• 89317-16-8 5-oxo-N-α-methylbenzyl-2-pyrrolidinepropanoic acid amide 
• 117155-74-5 4-(2-oxo-5-pyrrolidinyl)-2-butanone 
• 116454-70-7 5-(3'-oxopentyl)pyrrolidin-2-one 
• 116454-69-4 5-(3'-oxoheptyl)pyrrolidin-2-one 
• 89317-06-6 5-oxo-2-pyrrolidinepropanoic acid benzyl ester 
• 80243-73-8 5-(3-hydroxy-n-propyl)pyrrolidin-2-one 
• 106040-03-3 hexahydro-5-hydroxy-3H-pyrrolizin-3-one 

Relevant articles and documents

Low-valent titanium induced reductive coupling of nitriles with nitro compounds

The intermolecular and intramolecular coupling of a cyano group with a nitro group induced by a low-valent titanium reagent prepared from titanium tetrachloride and zinc powder was studied.

IMPROVED SYNTHESIS OF THE LUKES-SORM DILACTAM. NUCLEOPHILIC OPENING TO 5-SUBSTITUTED 2-PYRROLIDINE-2-ONES

An improved synthesis of the Lukes-Sorm dilactam 3 and conversion into several 5-substituted pyrrolidine-2-ones are described.

Process for the preparation of dihydro-1H-pyrrolizine-3,5-(2H,6H)-dione

Dihydro-1H-pyrrolizine-3,5-(2H,6H)-dione is produced in higher overall yield in a process which comprises catalytically hydrogenating a lower alkyl ester of 4-(hydroxyimino)heptanedioic acid in the presence of a tri-(lower alkyl)amine, followed by cyclization of the product thus produced in the presence of a cyclizing agent such as acetic anhydride.