7766-86-1

Usage

Uses

Used in Pharmaceutical Industry:
5-Oxo-2-pyrrolidinepropanoic acid is used as a synthetic intermediate for the production of a series of Dihydro-1H-pyrrolizine-3,5(2H,6H)-diones. These compounds exhibit the ability to reverse electroconvulsive shock (ECS) induced amnesia in mice, indicating their potential use in the development of treatments for memory disorders and cognitive impairments.

Upstream product

• 7766-85-0 4-aminopimelic acid 
• 77287-34-4 formamide 
• 18356-28-0 tetrahydro-pyrrolizin-3,5-dione 
• 7440-44-0 pyrographite 

Downstream Products

• 431988-79-3 5-(3-oxo-4-phenyl-butyl)-pyrrolidin-2-one 
• 643-20-9 pyrrolizidine 
• 89317-06-6 5-oxo-2-pyrrolidinepropanoic acid benzyl ester 
• 18356-28-0 tetrahydro-pyrrolizin-3,5-dione 

Relevant academic research and scientific papers

Process for the preparation of dihydro-1H-pyrrolizine-3,5-(2H,6H)-dione

Dihydro-1H-pyrrolizine-3,5-(2H,6H)-dione is produced in higher overall yield in a process which comprises catalytically hydrogenating a lower alkyl ester of 4-(hydroxyimino)heptanedioic acid in the presence of a tri-(lower alkyl)amine, followed by cyclization of the product thus produced in the presence of a cyclizing agent such as acetic anhydride.

5-Oxo-2-pyrrolidinepropanoic acid and derivatives for reversing electroshock amnesia

5-Oxo-2-pyrrolidinepropanoic acids, base addition salts, esters and amides are useful as agents for the reversal of amnesia. Pharmaceutical compositions containing said compounds and methods for using said compositions for treating senility and reversal of amnesia are also taught.

(E)-5-Hydroxypyrrolizidin-3-one: Versatile Synthon for the Synthesis of 5-Substituted 2-Pyrrolidones and (Z)-3-Alkylpyrrolizidines

Carbinol lactam 6 of secured stereochemistry served as a synthon to prepare 5-substituted 2-pyrrolidones and pyrrolizidin-3-ones.The relative stereochemistry of 6 and the dithioketal 13, prepared from the keto lactam 11, was established by single-crystal X-ray analysis.Desulfurization of the dithioketals 13 and 14 afforded the 5-n-propylpyrrolizidin-3-ones 15 and 16.Reduction of lactam 15 with LiAlH4 gave the racemic (Z)-3-n-propylpyrrolizidine (17), an analogue of a substance recently detected in ant species.