183742-33-8

Basic information

• Product Name: N-4-BOC-2-PIPERAZINEACETIC ACID METHYL ESTER
• Synonyms: TERT-BUTYL 3-(2-METHOXY-2-OXOETHYL)PIPERAZINE-1-CARBOXYLATE;N-4-BOC-2-PIPERAZINEACETIC ACID METHYL ESTER;METHYL 4-BOC-PIPERAZINE-2-ACETATE;METHYL PIPERAZIN-2-YLACETATE, N4-BOC PROTECTED;3-METHOXYCARBONYLMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;Methyl piperazin-2-ylacetate, N4-BOC protected 97%;(S)-N4-BOC-PIPERAZINE-2-ACETIC ACID METHYL ESTER;tert-butyl 3-(2-ethoxy-2-oxoethyl)piperazine-1-carboxylate
• CAS NO: 183742-33-8
• Molecular Formula: C₁₂H₂₂N₂O₄
• Molecular Weight: 258.31
• Product Categories: pharmacetical;Esters;Pyrans, Piperidines &Piperazines;Pyrans, Piperidines & Piperazines
• Mol File: 183742-33-8.mol

Chemical Properties

• Boiling Point: 336.2 °C at 760 mmHg
• Flash Point: 157.1 °C
• Appearance: /
• Density: 1.084 g/cm³
• Vapor Pressure: 0.000114mmHg at 25°C
• Storage Temp.: 2-8°C(protect from light)
• PKA: 7.26±0.40(Predicted)
• CAS DataBase Reference: N-4-BOC-2-PIPERAZINEACETIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: N-4-BOC-2-PIPERAZINEACETIC ACID METHYL ESTER(183742-33-8)
• EPA Substance Registry System: N-4-BOC-2-PIPERAZINEACETIC ACID METHYL ESTER(183742-33-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 183742-33-8(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry:
N-4-BOC-2-PIPERAZINEACETIC ACID METHYL ESTER is used as a synthetic intermediate for the preparation of various complex molecules and compounds. Its presence in the synthesis process is crucial for the formation of the desired products, particularly in the pharmaceutical and biochemical research industries.
Used in Pharmaceutical Industry:
N-4-BOC-2-PIPERAZINEACETIC ACID METHYL ESTER is used as a building block in the development of new pharmaceutical compounds. Its unique structure and the presence of the BOC protecting group make it a valuable component in the synthesis of potential drug candidates, contributing to the advancement of medicinal chemistry.
Used in Biochemical Research:
N-4-BOC-2-PIPERAZINEACETIC ACID METHYL ESTER is used as a reagent in biochemical research, where it may be involved in the study of enzyme mechanisms, receptor interactions, or other biological processes. Its versatility and the ability to incorporate it into larger molecules make it a valuable tool for researchers in the field.

InChI:InChI=1/C12H22N2O4/c1-12(2,3)18-11(16)14-6-5-13-9(8-14)7-10(15)17-4/h9,13H,5-8H2,1-4H3/p+1/t9-/m1/s1

Upstream product

• 368441-98-9 methyl piperazin-2-ylacetate 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 314741-49-6 1‐benzyl 4‐tert‐butyl (2S)‐2‐(2‐methoxy‐2‐oxoethyl)piperazine‐1,4‐dicarboxylate 
• 183742-32-7 1,4-dibenzyl-2-methoxycarbonylmethylpiperazine 
• 74651-77-7 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 394709-83-2 2-methoxycarbonylmethylpiperazine dihyrochloride 
• 1117-71-1 methyl 4-bromocrotonate 

Downstream Products

• 709029-95-8 [4-(6-chloro-benzo[b]thiophene-2-sulfonyl)-1-(4-cyano-benzoyl)-piperazin-2-yl]-acetic acid methyl ester 
• 406717-53-1 {4-(6-chloro-benzo[b]thiophene-2-sulfonyl)-1-[4-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)-benzoyl]-piperazin-2-yl}-acetic acid methyl ester 
• 406718-23-8 {4-(6-chloro-benzo[b]thiophene-2-sulfonyl)-1-[4-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)-benzoyl]-piperazin-2-yl}-acetic acid 
• 849107-18-2 4-(4-chloro-phenyl)-3-methoxycarbonylmethyl-piperazine-1-carboxylic acid tert-butyl ester 
• 1350457-67-8 5-(cyclopropylmethyl)-9-(4-fluorobenzyl)-5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine 
• 1350457-68-9 5-(cyclobutylmethyl)-9-(4-fluorobenzyl)-5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine 
• 1350457-72-5 5-(azetidin-3-ylmethyl)-9-(4-fluorobenzyl)-5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine 
• 1350460-10-4 9-(4-fluorobenzoyl)-7,7a,8,9,10,11-hexahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepin-6(5H)-one 
• 1350460-11-5 9-(4-fluorobenzyl)-5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine 
• 1350460-12-6 cyclobutyl[9-(4-fluorobenzyl)-7,7a,8,9,10,11-hexahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepin-5(6H)-yl]methanone 
• 1350460-16-0 tert-butyl 3-{[9-(4-fluorobenzyl)-7,7a,8,9,10,11-hexahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepin-5 (6H)-yl]carbonyl}azetidine-1-carboxylate 
• 1350460-17-1 tert-butyl 3-{[9-(4-fluorobenzyl)-7,7a,8,9,10,11-hexahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepin-5 (6H)-yl]methyl}azetidine-1-carboxylate 
• 1350460-05-7 2-(4-(t-butoxycarbonyl)-1-(2-nitrophenyl)piperazin-2-yl)acetic acid 
• 1350457-13-4 7-(4-bromobenzyl)-3-methyl-1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine 

Relevant articles and documents

NOVEL IN-VIVO PROBE FOR REAL TIME LONGITUDINAL MONITORING OF INDUCIBLE NITRIC-OXIDE SYNTHASE IN LIVING CELLS AND ANIMALS

The present disclosure relates to an in vivo fluorescent or radioactive probe represented by a compound of formula I which is capable of longitudinal imaging of inducible nitric oxide synthase (iNOS) expression in living cells and living animals on a real time basis. The probe of the present disclosure can exhibit specific and high affinity binding to the iNOS enzyme with reduced enzyme inhibitory property and also enables longitudinal monitoring of iNOS expression along with its activity or NO production in a same experimental subject throughout the progression of a physiological or disease process without employing separate subjects as controls and experimental. The present disclosure further provides a rapid and inexpensive real time method for visualizing iNOS expression and its activity in living cells and living animals precisely, conveniently and reversibly along with simultaneous in vivo imaging of its catalytic product, nitric oxide (NO) in live physiological settings.

Benzodiazepine and Pyridodiazepine Derivatives

The present application relates to benzodiazepine and pyridodiazepine derivatives of formula (I) wherein R1, R2, R3, R4, X1, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

Design, synthesis, and activity of 2-imidazol-1-ylpyrimidine derived inducible nitric oxide synthase dimerization inhibitors

By the screening of a combinatorial library for inhibitors of nitric oxide (NO) formation by the inducible isoform of nitric oxide synthase (iNOS) using a whole-cell assay, 2-(imidazol-1-yl)pyrimidines were identified. Compounds were found to inhibit the dimerization of iNOS monomers, thus preventing the formation of the dimeric, active form of the enzyme. Optimization led to the selection of the potent, selective, and orally available iNOS dimerization inhibitor, 21b, which significantly ameliorated adjuvant-induced arthritis in a rat model. Analysis of the crystal structure of the 21b-iNOS monomer complex provided a rationalization for both the SAR and the mechanism by which 21b blocks the formation of the protein-protein interaction present in the dimeric form of iNOS.

QUINOLINE DERIVATIVES AS ANTIBACTERIALS

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt and/or N-oxide thereof: corresponding novel medicaments, pharmaceutical compositions and/or methods of

N-heterocyclic derivatives as NOS inhibitors

N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.