368441-98-9

Basic information

• Product Name: 2-Piperazineaceticacid,methylester(9CI)
• Synonyms: 2-Piperazineaceticacid,methylester(9CI);METHYL PIPERAZIN-2-YLACETATE;Methyl 2-(piperazin-2-yl)acetate;Methyl piperazine-2-acetate
• CAS NO: 368441-98-9
• Molecular Formula: C₇H₁₄N₂O₂
• Molecular Weight: 158.2
• Product Categories: PIPERIDINE
• Mol File: 368441-98-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Piperazineaceticacid,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Piperazineaceticacid,methylester(9CI)(368441-98-9)
• EPA Substance Registry System: 2-Piperazineaceticacid,methylester(9CI)(368441-98-9)

Safety Data

• Hazardous Substances Data: 368441-98-9(Hazardous Substances Data)

Usage

General Description

2-Piperazineacetic acid, methyl ester (9CI) is a chemical compound typically used for research purposes, particularly as a biochemical for proteomics research. This substance is often mentioned in scientific literature for its role in organic synthesis processes. With its systematic name, methyl 2-(piperazin-1-yl)acetate, this compound falls under the classifications of esters, piperazines, and alkyl-acyl derivatives. This chemical is a highly-reactive substance due to the presence of its ester group, which results in relatively instability and sensitivity towards hydrolysis. However, further specific data about its applications and effects is limited.

Upstream product

• 70403-11-1 2-(1,4-dibenzyl-2-piperazinyl)acetonitrile 
• 94437-04-4 1,4-dibenzyl-2-hydroxypiperazine 
• 72351-59-8 ethyl 1,4-dibenzylpiperazin-2-carboxylate 
• 24225-89-6 2-chloromethyl-1,4-bis(phenylmethyl)piperazine 
• 1117-71-1 methyl 4-bromocrotonate 
• 183742-32-7 1,4-dibenzyl-2-methoxycarbonylmethylpiperazine 

Downstream Products

• 183742-33-8 3-(methoxycarbonylmethyl)piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

NOVEL IN-VIVO PROBE FOR REAL TIME LONGITUDINAL MONITORING OF INDUCIBLE NITRIC-OXIDE SYNTHASE IN LIVING CELLS AND ANIMALS

The present disclosure relates to an in vivo fluorescent or radioactive probe represented by a compound of formula I which is capable of longitudinal imaging of inducible nitric oxide synthase (iNOS) expression in living cells and living animals on a real time basis. The probe of the present disclosure can exhibit specific and high affinity binding to the iNOS enzyme with reduced enzyme inhibitory property and also enables longitudinal monitoring of iNOS expression along with its activity or NO production in a same experimental subject throughout the progression of a physiological or disease process without employing separate subjects as controls and experimental. The present disclosure further provides a rapid and inexpensive real time method for visualizing iNOS expression and its activity in living cells and living animals precisely, conveniently and reversibly along with simultaneous in vivo imaging of its catalytic product, nitric oxide (NO) in live physiological settings.

Design, synthesis, and activity of 2-imidazol-1-ylpyrimidine derived inducible nitric oxide synthase dimerization inhibitors

By the screening of a combinatorial library for inhibitors of nitric oxide (NO) formation by the inducible isoform of nitric oxide synthase (iNOS) using a whole-cell assay, 2-(imidazol-1-yl)pyrimidines were identified. Compounds were found to inhibit the dimerization of iNOS monomers, thus preventing the formation of the dimeric, active form of the enzyme. Optimization led to the selection of the potent, selective, and orally available iNOS dimerization inhibitor, 21b, which significantly ameliorated adjuvant-induced arthritis in a rat model. Analysis of the crystal structure of the 21b-iNOS monomer complex provided a rationalization for both the SAR and the mechanism by which 21b blocks the formation of the protein-protein interaction present in the dimeric form of iNOS.