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3-(4-Methoxy-phenyl)-1-pyridin-2-yl-propenone is a complex organic chemical compound with the molecular formula C16H13NO2. It is characterized by a pyridin-2-yl group attached to a propenone moiety, which in turn is connected to a 4-methoxy-phenyl ring. 3-(4-METHOXY-PHENYL)-1-PYRIDIN-2-YL-PROPENONE is known for its potential applications in the synthesis of various pharmaceuticals and agrochemicals due to its unique structure and reactivity. It is a colorless to pale yellow solid and is typically used as an intermediate in chemical reactions, contributing to the formation of more complex molecules. The compound's properties, such as its solubility and stability, make it a valuable component in the development of new drugs and other chemical products.

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  • 18451-44-0 Structure
  • Basic information

    1. Product Name: 3-(4-METHOXY-PHENYL)-1-PYRIDIN-2-YL-PROPENONE
    2. Synonyms: 3-(4-METHOXY-PHENYL)-1-PYRIDIN-2-YL-PROPENONE;3-(4-METHOXYPHENYL)-1-(2-PYRIDINYL)-2-PROPEN-1-ONE;(2E)-3-(4-methoxyphenyl)-1-(pyridin-2-yl)prop-2-en-1-one
    3. CAS NO:18451-44-0
    4. Molecular Formula: C15H13NO2
    5. Molecular Weight: 239.27
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 18451-44-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-(4-METHOXY-PHENYL)-1-PYRIDIN-2-YL-PROPENONE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-(4-METHOXY-PHENYL)-1-PYRIDIN-2-YL-PROPENONE(18451-44-0)
    11. EPA Substance Registry System: 3-(4-METHOXY-PHENYL)-1-PYRIDIN-2-YL-PROPENONE(18451-44-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 18451-44-0(Hazardous Substances Data)

18451-44-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 18451-44-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,4,5 and 1 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 18451-44:
(7*1)+(6*8)+(5*4)+(4*5)+(3*1)+(2*4)+(1*4)=110
110 % 10 = 0
So 18451-44-0 is a valid CAS Registry Number.

18451-44-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(4-methoxyphenyl)-1-pyridin-2-ylprop-2-en-1-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

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More Details:18451-44-0 SDS

18451-44-0Relevant articles and documents

Synthesis, growth, and characterization of 3-(4-Methoxyphenyl)-1-(pyridin- 2-yl) prop-2-en-1-one single crystal: A potential NLO material

Jayarama,Ravindra,Menezes, Anthoni Praveen,Dharmaprakash,Ng, Seik Weng

, p. 285 - 291 (2013)

New nonlinear optical chalcone material, 3-(4-Methoxyphenyl)-1-(pyridin-2- yl) prop-2-en-1-one (MPP) has been synthesized and grown as a high quality single crystal by the slow evaporation solution growth technique using acetone as solvent. The grown crys

From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity

Abdel-Halim, Mohammad,Sigler, Sara,Racheed, Nora A. S.,Hefnawy, Amr,Fathalla, Reem K.,Hammam, Mennatallah A.,Maher, Ahmed,Maxuitenko, Yulia,Keeton, Adam B.,Hartmann, Rolf W.,Engel, Matthias,Piazza, Gary A.,Abadi, Ashraf H.

supporting information, p. 4462 - 4477 (2021/05/04)

A ligand-based approach involving systematic modifications of a trisubstituted pyrazoline scaffold derived from the COX2 inhibitor, celecoxib, was used to develop novel PDE5 inhibitors. Novel pyrazolines were identified with potent PDE5 inhibitory activit

Coordination-driven self-assembly of anthraquinone-based metal-organic cages for photocatalytic selective [2 + 2] cycloaddition

Cui, Yong,Jiang, Hong,Jin, Yao,Liu, Yan,Tang, Xianhui,Zhang, Wenqiang

supporting information, p. 8533 - 8539 (2021/06/28)

Visible-light-promoted [2 + 2] cycloaddition provides a straightforward and efficient way to produce cyclobutanes, which are the core skeleton in commercial pharmaceuticals and fine chemicals. However, the control of the conformation to producesyn-head-to

Design, Synthesis, and Evaluation of Chalcone Derivatives as Multifunctional Agents against Alzheimer's Disease

Wang, Xiao-Qin,Zhou, Lu-Yi,Tan, Ren-Xian,Liang, Guo-Peng,Fang, Si-Xian,Li, Wei,Xie, Mei,Wen, Yu-Hao,Wu, Jia-Qiang,Chen, Yi-Ping

, (2021/10/19)

Fifteen chalcone derivatives 3a–3o were synthesized, and evaluated as multifunctional agents against Alzheimer's disease. In vitro studies revealed that these compounds inhibited self-induced Aβ1-42 aggregation effectively ranged from 45.9–94.5

Chiral bipyridine-annulated bicyclo[3.3.1]nonane N-oxide organocatalysts for stereoselective allylation and hydrosilylation reactions

?eimyt?, Simona,Ston?ius, Sigitas

, (2020/12/21)

The synthesis of chiral C2-symmetric bis(bipyridine N,N′-dioxide) and bis(bipyridine N-monooxide) derivatives featuring bipyridine-annulated bicyclo[3.3.1]nonane framework is reported. The new Lewis basic bipyridine N,N′-dioxides exhibited good

Light-Driven Enantioselective Synthesis of Pyrroline Derivatives by a Radical/Polar Cascade Reaction

Rodríguez, Ricardo I.,Mollari, Leonardo,Alemán, José

supporting information, p. 4555 - 4560 (2021/01/18)

Herein, a light-driven, atom-economical process that provides access to enantiomerically enriched substituted chiral 1-pyrroline derivatives is introduced. The strategy involves the distal functionalization of acyl heterocycles through a hydrogen-atom transfer (HAT) process and the use of tailor-made ketimines as reliable electrophilic partners. This transformation is translated into an enantiomerically controlled radical/polar cascade reaction in which water is produced as the sole by-product and stereoselectivity is dictated by coordination to a chiral-at-rhodium catalyst.

Synthesis and Luminescence Spectral Properties of New Cyano-Substituted 2,2′-Bipyridine Derivatives

Bardasov, I. N.,Belikov, M. Yu.,Ershov, O. V.,Ievlev, M. Yu.,Mayorov, N. S.,Shishlikova, M. A.

, p. 1961 - 1967 (2022/01/24)

Abstract: Previously unknown 2-{4-aryl-5-cyano-[2,2′-bipyridin]-6(1H)-ylidene}malononitriles were synthe-sized by reaction of 3-aryl-1-(pyridin-2-yl)prop-2-en-1-ones (azachalcones) with malononitrile dimer. Their colored solutions showed fluorescence in t

An Efficient Cyclic Di-AMP Based Artificial Metalloribozyme for Enantioselective Diels–Alder Reactions

Qi, Qianqian,Lv, Shuting,Hao, Min,Dong, Xingchen,Gu, Youkun,Wu, Peizhe,Zhang, Wenyue,Chen, Yashao,Wang, Changhao

, p. 4417 - 4424 (2020/06/17)

The diverse structures of nucleic acids as scaffolds have brought the significant advancement for DNA-based enantioselective catalysis, yet RNA-based enantioselective catalysis is lacking investigation. Herein, we report a small, natural RNA of cyclic di-AMP (c-di-AMP) and Cu2+ ions assemble into an artificial metalloribozyme (c-di-AMP·Cu2+), that could effectively catalyze the enantioselective Diels–Alder reactions with up to 80 percent ee. The enantioselective catalytic performance of c-di-AMP·Cu2+ has been studied by thorough investigations of different metal cofactors, c-di-AMP/Cu2+ molar ratios, additives, buffers and c-di-AMP analogues. In addition, the assembly of c-di-AMP·Cu2+ gives rise to 300-fold and 5-fold rate acceleration compared to the uncatalyzed reaction and Cu2+ ions, respectively. This work provides a simple and efficient strategy to construct the RNA-based catalysts that would expand the current nucleic acids-based catalysis and might hint the possible catalytic RNA in primordial chemistry.

Design, synthesis and neuropharmacological evaluation of new 2,4-disubstituted-1,5-benzodiazepines as CNS active agents

Bhatia, Rohit,Kumar, Bhupinder,Mehan, Sidharth,Monga, Vikramdeep,Singh, Gurpreet,Verma, Ramesh

, (2020/07/03)

Benzodiazepines (BZDs) represent a class of privilege scaffold in the modern era of medicinal chemistry as CNS active agents and BZD based drugs are used to treat different psychotic disorders. Inspired from the therapeutic potential of BZDs as promising CNS active agents, in the present work three different series of 1,5-benzodiazepines bearing various substitutions at position 2 and 4 of the benzodiazepine core were synthesized by condensing different substituted chalcones with o-phenylenediamine in the presence of piperidine as a base catalyst. Structural characterization of title compounds was done by using various analytical techniques such as IR, NMR, elemental analysis and mass spectral data. All the synthesized compounds (9a-d, 10a-e and 11a-c) were subjected to in vivo neuropharmacological studies to evaluate their CNS depressant and antiepileptic activity. Results of in vivo evaluation data showed that analogue 11b exhibited potent CNS depressant activity which was comparable to the standard drug diazepam. Compounds 10b and 10c displayed significant antiepileptic activity however they were less potent than the standard drug phenobarbitone. Molecular docking studies were performed using MOE software to find the interaction pattern and binding mode at the GABAA receptor (PDB Id: 6HUP). The results of the docking studies were in good agreement with the observed in vivo activity and revealed the satisfactory binding mode of the compounds within the binding site of the protein. The docking scores for the most promising candidates 10c, 11b and Diazepam were found to be ?9.18, ?9.46 and ?9.88, respectively. Further, the compounds showed compliance with the Lipinski's ‘rule of five’ and exhibited favourable drug-likeness scores. The identified leads can be explored further for the design and development of new BZD based psychotropic agents.

Synthesis, characterization and biological application of pyrazolo[1,5-a]pyrimidine based organometallic Re(I) complexes

Bhatt, Bhupesh S.,Pandya, Juhee G.,Patel, Mohan N.,Pathak, Chandramani,Vaidya, Foram U.,Varma, Reena R.

, p. 957 - 969 (2020/10/02)

The neutral rhenium(I) complexes (I-VI) of type [ReCl(CO)3Ln] {where L1 = 7-phenyl-5-(pyridin-2-yl)pyrazolo[1,5-a] pyrimidine, L2 = 7-(4-bromophenyl)-5-(pyridin-2-yl)pyrazolo[1,5-a]pyrimi- dine, L3 =

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