184677-62-1

Basic information

• Product Name: N-(2-phenoxyphenyl)propanamide
• Synonyms: N-(2-phenoxyphenyl)propanamide
• CAS NO: 184677-62-1
• Molecular Formula: C15H15NO2
• Molecular Weight: 241.2851
• Mol File: 184677-62-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-phenoxyphenyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-phenoxyphenyl)propanamide(184677-62-1)
• EPA Substance Registry System: N-(2-phenoxyphenyl)propanamide(184677-62-1)

Safety Data

• Hazardous Substances Data: 184677-62-1(Hazardous Substances Data)

Upstream product

• 79-03-8 propionyl chloride 
• 2688-84-8 2-phenoxyaniline 
• 2216-12-8 1-nitro-2-phenoxy-benzene 
• 1493-27-2 ortho-nitrofluorobenzene 
• 108-95-2 phenol 

Relevant articles and documents

Synthesis and enantioselective hydrogenation of seven-membered cyclic imines: Substituted dibenzo[b,f][1,4]oxazepines

Highly enantioselective hydrogenation of seven-membered cyclic imines, substituted dibenzo[b,f][1,4]oxazepines, was achieved, with up to 94% ee, by using the [Ir(COD)Cl]2/(S)-Xyl-C3*-TunePhos complex as the catalyst in the presence of morpholine-HCl.

Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands

Since the peripheral benzodiazepine receptor (PBR) has been primarily found as a high-affinity binding site for diazepam in rat kidney, numerous studies of it have been performed. However, the physiological role and functions of PBR have not been fully elucidated. Currently, we presented the pharmacological profile of two high and selective PBR ligands, N-(2,5-dimethoxybenzyl)-N-(4-fluoro-2-phenoxyphenyl)acetamide (7-096, DAA1106) (PBR: IC50=0.28 nM) and N-(4-chloro-2-phenoxyphenyl)-N-(2- isopropoxybenzyl)acetamide (7-099, DAA1097) (PBR: IC50=0.92 nM). The compounds are aryloxyanilide derivatives, and identified with known PBR ligands such as benzodiazepine (1, Ro5-4864), isoquinoline (2, PK11195), imidazopyridine (3, Alpidem), and indole (5, FGIN-1-27) derivatives. The aryloxyanilide derivatives, which have been derived by opening the diazepine ring of 1, are a novel class as PBR ligands and have exhibited high and selective affinity for peripheral benzodiazepine receptors (PBRs). These novel derivatives would be useful for exploring the functions of PBR. In this paper, the design, synthesis and structure-affinity relationships of aryloxyanilide derivatives are described.