1849-55-4

Basic information

• Product Name: 3-Hydroxypyridine-2-carboxaldehyde
• Synonyms: IFLAB-BB F1957-0037;3-HYDROXY-PYRIDINE-2-CARBALDEHYDE;3-HYDROXYPYRIDINE-2-CARBOXALDEHYDE;2-FORMYL-3-HYDROXYPYRIDINE;3-Hydroxypicolinaldehyde;3-Hydroxypicolinaldehyde, 2-Formyl-3-hydroxypyridine;2-Pyridinecarboxaldehyde, 3-hydroxy-;3-Hydroxy-2-pyridinecarbaldehyde
• CAS NO: 1849-55-4
• Molecular Formula: C₆H₅NO₂
• Molecular Weight: 123.11
• EINECS: -0
• Product Categories: pharmacetical;Aldehydes;Pyridines;Pyridine
• Mol File: 1849-55-4.mol

Chemical Properties

• Melting Point: 80-82°C (subl.)
• Boiling Point: 96-100°C/30mm
• Flash Point: 130.6 °C
• Appearance: /
• Density: 1.327 g/cm³
• Vapor Pressure: 0.00106mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: pK1:3.40(＋1);pK2:6.95(OH)(20°C)
• CAS DataBase Reference: 3-Hydroxypyridine-2-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxypyridine-2-carboxaldehyde(1849-55-4)
• EPA Substance Registry System: 3-Hydroxypyridine-2-carboxaldehyde(1849-55-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 1849-55-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Hydroxypyridine-2-carboxaldehyde serves as a key intermediate in the synthesis of various pharmaceutical compounds. It is particularly utilized in the production of antihistamines and antifungal agents, contributing to the development of medications that address a range of health conditions.
Used in Agrochemical Production:
Beyond its pharmaceutical applications, 3-Hydroxypyridine-2-carboxaldehyde also functions as a building block in the creation of agrochemicals. Its role in this industry is vital for the synthesis of products that protect crops and enhance agricultural yields.
Used in Specialty Chemicals:
3-Hydroxypyridine-2-carboxaldehyde's versatility extends to other specialty chemical applications, where it is employed to produce a variety of specialized products that cater to unique industrial needs.

InChI:InChI=1/C6H5NO2/c8-4-5-6(9)2-1-3-7-5/h1-4,9H

Upstream product

• 14047-53-1 3-hydroxy-2-hydroxymethylpyridine 

Downstream Products

• 114658-14-9 2-cyano-3-hydroxypyridine 1-oxide 
• 74686-57-0 3-hydroxy-2-pyridinealdoxime 
• 1350321-08-2 C₁₈H₁₄N₄O 
• 1431151-71-1 (E)-2-(((3,5-bis(trifluoromethyl)phenyl)imino)methyl)pyridin-3-ol 
• 1431152-24-7 3-((3,5-bis(trifluoromethyl)phenyl)amino)-N,N-diethyl-2,3-dihydrofuro[3,2-b]pyridine-2-carboxamide 

Relevant articles and documents

Polymethylenedioxy bis(2-hydroxyiminomethylpyridinium) as in vitro reactivators of organophosphorous inhibited eel acetylcholinesterase

The synthesis and in vitro AChE reactivating potency of 5 new bridged pyridinium-2 carbaldoximes are described.Tested as reactivators and protectors in vitro against 5 organophosphorous inhibitors, they show a particularly interesting activity against paraoxon and tabun.These oximes themselves are reversible AChE inhibitors.Keywords - acetylcholinesterase reactivators; organophosphorous poisons; bridged pyridinium oximes.

SPECTRAL STUDY OF 1,5-BIS(3-HYDROXY-2-PYRIDYLMETHYLIDENE) THIOCARBOHYDRAZONE

The synthesis, spectral study and some of the physico-chemical properties of 1,5-bis(3-hydroxy-2-pyridylmethylidene) thiocarbohydrazone are described.The spectral characteristics of metallic ions-reagent are considered to establish the possible use of the compound as analytical photometric reagent.

Imparting hysteretic behavior to spin transition in neutral mononuclear complexes

A series of spin transition neutral compounds [FeL(NCS)2] has been synthesized and characterized by means of magnetic susceptibility studies, X-ray diffraction, IR and M?ssbauer spectroscopic, and calorimetric measurements (L = N,N-bis((3-alkox

Palladium(II) complexes of the thiosemicarbazone and N- ethylthiosemicarbazone of 3-hydroxypyridine-2-carbaldehyde: Synthesis, properties, and X-ray crystal structure

Two novel, stable PdII complexes, compounds 3 and 4, of two 3-hydroxypyridine-2-carbaldehyde thiosemicarbazones, 1 and 2, resp., were prepared from Li2PdCl4. The single-crystal X-ray structure of complex 3 (=[Pd(2)Cl]) shows that the ligand monoanion coordinates in a planar conformation to the metal via the pyridyl N-, the imine N-, and the thiolato S-atoms. Intermolecular H-bonds, π-π, and CH...π interactions lead to a two-dimensional supramolecular assembly. The electronic, IR, UV/VIS, and NMR spectroscopic data of the two complexes are reported, together with their electrochemical properties. A sophisticated experimental procedure was used to determine the multiple dissociation constants of the ligands 1 and 2 by UV/VIS titration.

Design, synthesis, testing, and quantitative structure - Activity relationship analysis of substituted salicylaldehyde Schiff bases of 1-amino-3-hydroxyguanidine tosylate as new antiviral agents against coronavirus

Further modifications of the structural features of Schiff bases of hydroxyaminoguanidines (SB-HAG) led to nine substituted salicylaldehyde Schiff bases of HAG (SSB-HAG) derivatives and three other SB-HAG derivatives. These new compounds were tested for t