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3-Hydroxypyridine-2-carboxaldehyde, abbreviated as 3-HPA, is a chemical compound with the molecular formula C6H5NO2. It is a derivative of pyridine, characterized by its light yellow crystalline solid appearance and solubility in water. 3-Hydroxypyridine-2-carboxaldehyde has a distinctive odor and requires careful handling and adherence to safety protocols during its use.

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  • 1849-55-4 Structure
  • Basic information

    1. Product Name: 3-Hydroxypyridine-2-carboxaldehyde
    2. Synonyms: IFLAB-BB F1957-0037;3-HYDROXY-PYRIDINE-2-CARBALDEHYDE;3-HYDROXYPYRIDINE-2-CARBOXALDEHYDE;2-FORMYL-3-HYDROXYPYRIDINE;3-Hydroxypicolinaldehyde;3-Hydroxypicolinaldehyde, 2-Formyl-3-hydroxypyridine;2-Pyridinecarboxaldehyde, 3-hydroxy-;3-Hydroxy-2-pyridinecarbaldehyde
    3. CAS NO:1849-55-4
    4. Molecular Formula: C6H5NO2
    5. Molecular Weight: 123.11
    6. EINECS: -0
    7. Product Categories: pharmacetical;Aldehydes;Pyridines;Pyridine
    8. Mol File: 1849-55-4.mol
  • Chemical Properties

    1. Melting Point: 80-82°C (subl.)
    2. Boiling Point: 96-100°C/30mm
    3. Flash Point: 130.6 °C
    4. Appearance: /
    5. Density: 1.327 g/cm3
    6. Vapor Pressure: 0.00106mmHg at 25°C
    7. Refractive Index: 1.629
    8. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    9. Solubility: Chloroform (Slightly), Methanol (Slightly)
    10. PKA: pK1:3.40(+1);pK2:6.95(OH)(20°C)
    11. CAS DataBase Reference: 3-Hydroxypyridine-2-carboxaldehyde(CAS DataBase Reference)
    12. NIST Chemistry Reference: 3-Hydroxypyridine-2-carboxaldehyde(1849-55-4)
    13. EPA Substance Registry System: 3-Hydroxypyridine-2-carboxaldehyde(1849-55-4)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26-36/37/39
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1849-55-4(Hazardous Substances Data)

1849-55-4 Usage

Uses

Used in Pharmaceutical Industry:
3-Hydroxypyridine-2-carboxaldehyde serves as a key intermediate in the synthesis of various pharmaceutical compounds. It is particularly utilized in the production of antihistamines and antifungal agents, contributing to the development of medications that address a range of health conditions.
Used in Agrochemical Production:
Beyond its pharmaceutical applications, 3-Hydroxypyridine-2-carboxaldehyde also functions as a building block in the creation of agrochemicals. Its role in this industry is vital for the synthesis of products that protect crops and enhance agricultural yields.
Used in Specialty Chemicals:
3-Hydroxypyridine-2-carboxaldehyde's versatility extends to other specialty chemical applications, where it is employed to produce a variety of specialized products that cater to unique industrial needs.

Check Digit Verification of cas no

The CAS Registry Mumber 1849-55-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,4 and 9 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1849-55:
(6*1)+(5*8)+(4*4)+(3*9)+(2*5)+(1*5)=104
104 % 10 = 4
So 1849-55-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H5NO2/c8-4-5-6(9)2-1-3-7-5/h1-4,9H

1849-55-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-hydroxypyridine-2-carbaldehyde

1.2 Other means of identification

Product number -
Other names 2-Formyl-3-hydroxypyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1849-55-4 SDS

1849-55-4Relevant articles and documents

Polymethylenedioxy bis(2-hydroxyiminomethylpyridinium) as in vitro reactivators of organophosphorous inhibited eel acetylcholinesterase

Demerseman, Pierre,Kiffer, Daniel,Debussche, Laurent,Lion, Claude,Royer, Rene,Sentenac-Roumanou, Henri

, p. 63 - 68 (1988)

The synthesis and in vitro AChE reactivating potency of 5 new bridged pyridinium-2 carbaldoximes are described.Tested as reactivators and protectors in vitro against 5 organophosphorous inhibitors, they show a particularly interesting activity against paraoxon and tabun.These oximes themselves are reversible AChE inhibitors.Keywords - acetylcholinesterase reactivators; organophosphorous poisons; bridged pyridinium oximes.

SPECTRAL STUDY OF 1,5-BIS(3-HYDROXY-2-PYRIDYLMETHYLIDENE) THIOCARBOHYDRAZONE

Romero, E. Sanchez,Ariza, J.L. Gomez,Perez, A. Guiraum

, p. 509 - 512 (1986)

The synthesis, spectral study and some of the physico-chemical properties of 1,5-bis(3-hydroxy-2-pyridylmethylidene) thiocarbohydrazone are described.The spectral characteristics of metallic ions-reagent are considered to establish the possible use of the compound as analytical photometric reagent.

Imparting hysteretic behavior to spin transition in neutral mononuclear complexes

Seredyuk, Maksym,Znovjyak, Kateryna,Mu?oz, M. Carmen,Galyametdinov, Yurii,Fritsky, Igor O.,Real, Jose A.

, p. 39627 - 39635 (2016/05/24)

A series of spin transition neutral compounds [FeL(NCS)2] has been synthesized and characterized by means of magnetic susceptibility studies, X-ray diffraction, IR and M?ssbauer spectroscopic, and calorimetric measurements (L = N,N-bis((3-alkox

Palladium(II) complexes of the thiosemicarbazone and N- ethylthiosemicarbazone of 3-hydroxypyridine-2-carbaldehyde: Synthesis, properties, and X-ray crystal structure

Demertzis, Mavroudis A.,Yadav, Paras Nath,Kovala-Demertzi, Dimitra

, p. 1959 - 1970 (2007/10/03)

Two novel, stable PdII complexes, compounds 3 and 4, of two 3-hydroxypyridine-2-carbaldehyde thiosemicarbazones, 1 and 2, resp., were prepared from Li2PdCl4. The single-crystal X-ray structure of complex 3 (=[Pd(2)Cl]) shows that the ligand monoanion coordinates in a planar conformation to the metal via the pyridyl N-, the imine N-, and the thiolato S-atoms. Intermolecular H-bonds, π-π, and CH...π interactions lead to a two-dimensional supramolecular assembly. The electronic, IR, UV/VIS, and NMR spectroscopic data of the two complexes are reported, together with their electrochemical properties. A sophisticated experimental procedure was used to determine the multiple dissociation constants of the ligands 1 and 2 by UV/VIS titration.

Design, synthesis, testing, and quantitative structure - Activity relationship analysis of substituted salicylaldehyde Schiff bases of 1-amino-3-hydroxyguanidine tosylate as new antiviral agents against coronavirus

Wang,Keck,Lien,Lai

, p. 608 - 614 (2007/10/02)

Further modifications of the structural features of Schiff bases of hydroxyaminoguanidines (SB-HAG) led to nine substituted salicylaldehyde Schiff bases of HAG (SSB-HAG) derivatives and three other SB-HAG derivatives. These new compounds were tested for t

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