1849-55-4

Basic information

• Product Name: 3-Hydroxypyridine-2-carboxaldehyde
• Synonyms: IFLAB-BB F1957-0037;3-HYDROXY-PYRIDINE-2-CARBALDEHYDE;3-HYDROXYPYRIDINE-2-CARBOXALDEHYDE;2-FORMYL-3-HYDROXYPYRIDINE;3-Hydroxypicolinaldehyde;3-Hydroxypicolinaldehyde, 2-Formyl-3-hydroxypyridine;2-Pyridinecarboxaldehyde, 3-hydroxy-;3-Hydroxy-2-pyridinecarbaldehyde
• CAS NO: 1849-55-4
• Molecular Formula: C₆H₅NO₂
• Molecular Weight: 123.11
• EINECS: -0
• Product Categories: pharmacetical;Aldehydes;Pyridines;Pyridine
• Mol File: 1849-55-4.mol

Chemical Properties

• Melting Point: 80-82°C (subl.)
• Boiling Point: 96-100°C/30mm
• Flash Point: 130.6 °C
• Appearance: /
• Density: 1.327 g/cm³
• Vapor Pressure: 0.00106mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: pK1:3.40(＋1);pK2:6.95(OH)(20°C)
• CAS DataBase Reference: 3-Hydroxypyridine-2-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxypyridine-2-carboxaldehyde(1849-55-4)
• EPA Substance Registry System: 3-Hydroxypyridine-2-carboxaldehyde(1849-55-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 1849-55-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Hydroxypyridine-2-carboxaldehyde serves as a key intermediate in the synthesis of various pharmaceutical compounds. It is particularly utilized in the production of antihistamines and antifungal agents, contributing to the development of medications that address a range of health conditions.
Used in Agrochemical Production:
Beyond its pharmaceutical applications, 3-Hydroxypyridine-2-carboxaldehyde also functions as a building block in the creation of agrochemicals. Its role in this industry is vital for the synthesis of products that protect crops and enhance agricultural yields.
Used in Specialty Chemicals:
3-Hydroxypyridine-2-carboxaldehyde's versatility extends to other specialty chemical applications, where it is employed to produce a variety of specialized products that cater to unique industrial needs.

InChI:InChI=1/C6H5NO2/c8-4-5-6(9)2-1-3-7-5/h1-4,9H

Upstream product

• 14047-53-1 3-hydroxy-2-hydroxymethylpyridine 

Downstream Products

• 123541-27-5 C₇H₉N₅O₂*C₇H₈O₃S 
• 73737-01-6 C₁₃H₁₃N₃O₃S 
• 25957-17-9 3-phenyl-2H-pyrano<3,2-b>pyridin-2-one 
• 932-35-4 3-hydroxypyridine-2-carbonitrile 
• 3814-79-7 3-hydroxypyridine-2-carboxaldehyde thiosemicarbazone 

Relevant articles and documents

Polymethylenedioxy bis(2-hydroxyiminomethylpyridinium) as in vitro reactivators of organophosphorous inhibited eel acetylcholinesterase

The synthesis and in vitro AChE reactivating potency of 5 new bridged pyridinium-2 carbaldoximes are described.Tested as reactivators and protectors in vitro against 5 organophosphorous inhibitors, they show a particularly interesting activity against paraoxon and tabun.These oximes themselves are reversible AChE inhibitors.Keywords - acetylcholinesterase reactivators; organophosphorous poisons; bridged pyridinium oximes.

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Two novel, stable PdII complexes, compounds 3 and 4, of two 3-hydroxypyridine-2-carbaldehyde thiosemicarbazones, 1 and 2, resp., were prepared from Li2PdCl4. The single-crystal X-ray structure of complex 3 (=[Pd(2)Cl]) shows that the ligand monoanion coordinates in a planar conformation to the metal via the pyridyl N-, the imine N-, and the thiolato S-atoms. Intermolecular H-bonds, π-π, and CH...π interactions lead to a two-dimensional supramolecular assembly. The electronic, IR, UV/VIS, and NMR spectroscopic data of the two complexes are reported, together with their electrochemical properties. A sophisticated experimental procedure was used to determine the multiple dissociation constants of the ligands 1 and 2 by UV/VIS titration.

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