14047-53-1

Basic information

• Product Name: 2-(HYDROXYMETHYL)PYRIDIN-3-OL
• Synonyms: 2-(HYDROXYMETHYL)PYRIDIN-3-OL;3-hydroxypyridine-2-methanol;3-Hydroxy-2-pyridylmethanol;2-Pyridinemethanol, 3-hydroxy-;2-(Hydroxymethyl)pyridine-3-ol;3-Hydroxy-2-pyridinemethanol
• CAS NO: 14047-53-1
• Molecular Formula: C₆H₇NO₂
• Molecular Weight: 125.13
• EINECS: 237-883-9
• Product Categories: pharmacetical
• Mol File: 14047-53-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 132 °C
• Boiling Point: 393.2 °C at 760 mmHg
• Flash Point: 191.6 °C
• Appearance: /
• Density: 1.318 g/cm³
• Vapor Pressure: 6.87E-07mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: Room temperature.
• PKA: 8.10±0.10(Predicted)
• CAS DataBase Reference: 2-(HYDROXYMETHYL)PYRIDIN-3-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(HYDROXYMETHYL)PYRIDIN-3-OL(14047-53-1)
• EPA Substance Registry System: 2-(HYDROXYMETHYL)PYRIDIN-3-OL(14047-53-1)

Safety Data

• Hazardous Substances Data: 14047-53-1(Hazardous Substances Data)

Usage

General Description

2-(Hydroxymethyl)pyridin-3-ol is a chemical compound with the molecular formula C6H7NO2. It is a derivative of pyridine and contains a hydroxymethyl group. 2-(HYDROXYMETHYL)PYRIDIN-3-OL is a colorless to yellow liquid or solid and is used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a building block for the preparation of various heterocyclic compounds. Additionally, 2-(Hydroxymethyl)pyridin-3-ol has potential biological activities and is being researched for its potential applications in medicine and healthcare.

InChI:InChI=1/C6H7NO2/c8-4-5-6(9)2-1-3-7-5/h1-3,8-9H,4H2

Upstream product

• 3131-03-1 pristinamycin IA 
• 80322-74-3 2-chloromethyl-3-hydroxypyridine hydrochloride 
• 67992-22-7 3-acetoxy-2-acetoxymethyl-pyridine 
• 109-00-2 3-HYDROXYPYRIDINE 
• 50-00-0 formaldehyd 

Downstream Products

• 1609986-26-6 (3-((4,5-dimethoxy-2-nitrobenzyl)oxy)pyridin-2-yl)methanol 
• 1609986-37-9 C₂₆H₂₀F₃N₃O₉ 
• 14173-30-9 3-hydroxy-2-hydroxymethylpyridine hydrochloride 

Relevant articles and documents

Synthesis and biological activity of quaternary phosphonium salts based on 3-hydroxypyridine and 4-deoxypyridoxine

Methods for the synthesis of quaternary phosphonium salts based on 3-hydroxypyridine and 4-deoxypyridoxine were developed. Some of obtained compounds possess high antibacterial and antitumor activity in vitro.

Acid-catalysed Rearrangement of 3-Acyl-6-alkoxy-5,6-dihydro-4H-1,2-oxazines: a Route to 3-Alkoxypyridine 1-Oxides

6-Alkoxy-5,6-dihydro-4H-1,2-oxazines (2) and (5) have been prepared by the reaction of chloro oximes (1) with enol ethers in the presence of sodium carbonate.The 3-phenyloxazine (2) rearranges to the nitrone (3) in methanolic HCl.In contrast, the 3-acyloxazines (5a-e) are converted into 3-alkoxypyridine 1-oxides (7) in aqueous alcoholic HCl.With HCl in acetic acid the oxazine (5a) is converted into 2-chloromethyl-3-hydroxypuridine hydrochloride (10a); analogous reactions take place with oxazines (5b) and (5d).Possible mechanisms for these reactions are discussed.