18511-61-0 Usage
Uses
Used in Pharmaceutical Industry:
Benzene, 1-cyclopropyl-3-fluorois utilized as a key intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs. Its unique properties allow for the development of new medications with specific therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, Benzene, 1-cyclopropyl-3-fluoroserves as an intermediate in the production of agrochemicals, contributing to the development of pesticides and other agricultural products that enhance crop protection and yield.
Used in Specialty Chemicals Production:
Benzene, 1-cyclopropyl-3-fluorois also employed in the manufacture of specialty chemicals, where its distinctive structure and properties are leveraged to create high-value products for specific applications in various industries.
Used in Organic Synthesis:
Benzene, 1-cyclopropyl-3-fluoroacts as a building block in organic synthesis, enabling the creation of a wide range of organic compounds for research and commercial purposes. Its versatility in chemical reactions makes it a valuable component in the synthesis of complex organic molecules.
It is crucial to handle and store Benzene, 1-cyclopropyl-3-fluorowith caution due to its flammability and potential health hazards, as well as its classification as a potential environmental contaminant. Proper safety measures should be implemented to mitigate risks associated with its use.
Check Digit Verification of cas no
The CAS Registry Mumber 18511-61-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,5,1 and 1 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 18511-61:
(7*1)+(6*8)+(5*5)+(4*1)+(3*1)+(2*6)+(1*1)=100
100 % 10 = 0
So 18511-61-0 is a valid CAS Registry Number.
18511-61-0Relevant articles and documents
Aminofluorination of Cyclopropanes: A Multifold Approach through a Common, Catalytically Generated Intermediate
Pitts, Cody Ross,Ling, Bill,Snyder, Joshua A.,Bragg, Arthur E.,Lectka, Thomas
supporting information, p. 6598 - 6609 (2016/06/09)
We have discovered a highly regioselective aminofluorination of cyclopropanes. Remarkably, four unique sets of conditions-two photochemical, two purely chemical-generated the same aminofluorinated adducts in good to excellent yields. The multiple, diverse ways in which the reaction could be initiated provided valuable clues that led to the proposal of a "unifying" chain propagation mechanism beyond initiation, tied by a common intermediate. In all, the proposed mechanism herein is substantiated by product distribution studies, kinetic analyses, LFERs, Rehm-Weller estimations of ΔGET, competition experiments, KIEs, fluorescence data, and DFT calculations. From a more physical standpoint, transient-absorption experiments have allowed direct spectroscopic observation of radical ion intermediates (previously only postulated or probed indirectly in photochemical fluorination systems) and, consequently, have provided kinetic support for chain propagation. Lastly, calculations suggest that solvent may play an important role in the cyclopropane ring-opening step.
