185526-66-3

Basic information

• Product Name: 2-(1'-(tert-butoxycarbonyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid
• Synonyms: 2-(1'-(tert-butoxycarbonyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid;1'-[(tert-Butoxy)carbonyl]-2,3-dihydrospiro[1H-indene-1,4'-piperidine]-3-acetic acid;1'-Boc-2,3-dihydrospiro[indene-1,4'-piperidine]-3-acetic acid;2-(1'-(tert-Butoxycarbonyl)-2,3-dihydrospiro[indene-1,4'-piperidin]-3-yl)acetic acid
• CAS NO: 185526-66-3
• Molecular Formula: C₂₀H₂₇NO₄
• Molecular Weight: 345.43
• Mol File: 185526-66-3.mol

Chemical Properties

• Appearance: /
• Density: 1.20
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(1'-(tert-butoxycarbonyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1'-(tert-butoxycarbonyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid(185526-66-3)
• EPA Substance Registry System: 2-(1'-(tert-butoxycarbonyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid(185526-66-3)

Safety Data

• Hazardous Substances Data: 185526-66-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(1'-(tert-butoxycarbonyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid is used as a chemical intermediate for the synthesis of various pharmaceuticals due to its unique structural features and potential to be modified for specific biological activities.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-(1'-(tert-butoxycarbonyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid is utilized as a scaffold for the development of new drugs, given its potential to be optimized for specific therapeutic targets.
Used in Drug Development:
2-(1'-(tert-butoxycarbonyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid is employed in drug development as a lead compound, which can be further modified to enhance its pharmacological properties, such as potency, selectivity, and bioavailability.
Note: Since the provided materials do not specify particular applications or industries for 2-(1'-(tert-butoxycarbonyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetic acid, the uses listed are general and based on the compound's characteristics and typical applications of similar organic compounds in the pharmaceutical and medicinal chemistry fields.

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 159634-59-0 2,3-dihydro-3-oxo-spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester 
• 197648-70-7 3-[[[2-oxo-4-phenylmethyloxazolidin-3-yl]carbonyl]methyl]-2,3-dihydrospiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester 
• 143-33-9 sodium cyanide 
• 185526-32-3 1'-[(1,1-Dimethylethoxy)carbonyl]-2,3-dihydrospiro(1H-indene-1,4'-piperidine]-3-carboxylic Acid 

Relevant articles and documents

The design and synthesis of orally active short duration spiroindane growth hormone secretagogues

The design, synthesis, and activities of a series of short duration spiroindane growth hormone secretagogues are reported. Incorporation of a readily metabolized ester into the spiroindane benzylic position provided a series of highly potent orally active secretagogues with a short duration of action.

Spiro piperidines and homologs promote release of growth hormone

There are disclosed certain novel compounds identified as spiro piperidines and homologs which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such spiro compounds as the active ingredient thereof are also disclosed.