159634-59-0

Basic information

• Product Name: N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE
• Synonyms: TERT-BUTYL 3-OXO-2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]-1'-CARBOXYLATE;N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE;2,3-Dihydro-3-oxo-spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester;tert-butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-car;Spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid, 2,3-dihydro-3-oxo- 1,1-diMethyl ethyl ester;Caboxylate;1'-Boc-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine];2,3-dihydro-3-oxo-spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester
• CAS NO: 159634-59-0
• Molecular Formula: C₁₈H₂₃NO₃
• Molecular Weight: 301.38
• Mol File: 159634-59-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 120-122 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))
• Boiling Point: 439.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.17
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: -0.80±0.20(Predicted)
• CAS DataBase Reference: N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE(159634-59-0)
• EPA Substance Registry System: N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE(159634-59-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 159634-59-0(Hazardous Substances Data)

Usage

General Description

N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE is a chemical compound with the molecular formula C23H29NO5. It is a derivative of indanone, which is a cyclic ketone compound, and contains a spiro-piperidine group. The compound is commonly used in organic synthesis, drug discovery, and medicinal chemistry research. It is known for its potential biological activities and pharmacological properties, and has been studied for its potential as a therapeutic agent in treating various diseases. N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE is a versatile chemical that has gained attention in the scientific community for its diverse applications and potential pharmaceutical uses.

Upstream product

• 137419-24-0 1'-(tert-butyloxycarbonyl)spiro<1H-indene-1,4'-piperidine> 
• 118753-70-1 N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine 
• 95-13-6 1-indene 
• 13292-87-0 dimethylsulfide borane complex 
• 185525-42-2 tert-butyl 3-hydroxy-2,3-dihydrospiro[indene-1,4’-piperidine]-1‘-carboxylate 
• 148835-99-8 N-Boc spiroindane 

Downstream Products

• 180465-55-8 spiro[1H-indene-1,4'-piperidin]-3(2H)-one 
• 159634-63-6 Spiro(2-oxo-1,2,3,4-tetrahydroquinoline-4,4'-piperidine) 
• 159634-65-8 2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidin]-1-one 
• 873056-18-9 1,2,3,4-tetrahydroquinolin-4-spiro-4'-(N'-benzylpiperidine) 
• 873056-16-7 1'-benzyl-spiro[1H-indene-1,4'-piperidin]-3(2H)-one 
• 917898-66-9 1-neopentyl-1'-(2-nitrophenyl)-2',3'-dihydro-1'H-spiro[piperidine-4,4'-quinoline] 
• 1138522-08-3 t-butyl 3-hydroxy-3-methyl-2,3-dihydrospiro(indene-1,4'-piperidine)-1'-carboxylate 
• 231938-20-8 spiro[indene-1,4'-piperidin]-3(2H)-one hydrochloride 
• 185525-96-6 C₃₂H₄₁N₃O₆ 
• 185526-08-3 C₃₃H₄₃N₃O₅ 
• 185525-94-4 C₂₈H₃₄N₂O₅ 
• 185525-95-5 C₂₃H₂₆N₂O₃ 
• 185526-66-3 1'-[(1,1-dimethylethoxy)carbonyl]-2,3-dihydrospiro[1H-indene-1,4'-piperidine]-3-acetic acid 

Relevant articles and documents

Novel heterocyclic derivative capable of being used as SHP2 inhibitor

The invention relates to a novel heterocyclic derivative capable of being used as an SHP2 inhibitor, specifically relates to a compound shown by a formula I or pharmaceutically acceptable salts thereof, further relates to a use of the compound shown by the formula I or the pharmaceutically acceptable salts thereof and a pharmaceutical composition thereof in drug preparation, and particularly relates to a use in preparation of drugs for treatment, inhibition or prevention of diseases or discomforts mediated by SHP2 activity.

NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS

This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.

NOVEL SPIRO COMPOUND AND MEDICINE COMPRISING THE SAME

It is to provide a novel compound useful for preventing and/or treating diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome. A spiro compound represented by the following general for