186293-26-5Relevant articles and documents
Silver(I) complexes with symmetrical Schiff bases: Synthesis, structural characterization, DFT studies and antimycobacterial assays
Paiva, Isabela L.,De Carvalho, Gustavo S.G.,Da Silva, Adilson D.,Corbi, Pedro P.,Bergamini, Fernando R.G.,Formiga, André L.B.,Diniz, Renata,Do Carmo, Weberton R.,Leite, Clarice Q.F.,Pavan, Fernando R.,Cuin, Alexandre
, p. 104 - 109 (2013)
Synthesis, structural and spectroscopic characterizations, molecular modeling and antimycobacterial assays of new silver(I) complexes with two Schiff bases - MBDA and MBDB - are reported. The complexes [Ag(MBDA) 2]NO3, or AgMBDA, and
A facile synthesis and characterization of the novel 2,2-dichloro-1-[3-(2,2-dichloro-acetyl)-2-(4-methoxy-phenyl)-imidazolidin -1-yl]-ethanone
Uenaleroglu, Canan,Temelli, Baris,Hoekelek, Tuncer
, p. 3255 - 3261 (2002)
The synthesis of (2,2-dichloro-1-[3-(2,2-dichloro-acetyl)-2-(4-methoxy-phenyl)-imidazolidin -1-yl]-ethanone by a facile one-pot reaction between N,N′-bis(4-methoxy-benzylidene)-ethane-1,2-diamine and dichloroacetyl chloride is described. The structure was
Modeling and biological evaluation of 3,3′-(1,2-ethanediyl)bis[2-(4-methoxyphenyl)-thiazolidin-4-one], a new synthetic cyclooxygenase-2 inhibitor
Ottaná, Rosaria,Mazzon, Emanuela,Dugo, Laura,Monforte, Francesca,Maccari, Rosanna,Sautebin, Lidia,De Luca, Grazia,Vigorita, Maria Gabriella,Alcaro, Stefano,Ortuso, Francesco,Caputi, Achille P,Cuzzocrea, Salvatore
, p. 71 - 80 (2002)
Within the series of chiral 3,3′-(1,2-ethanediyl)bis[2-arylthiazolidin-4-ones], the 3,4-dimethoxyphenyl substituted derivative was found in the primary anti-inflammatory screening to be endowed with superior in vivo properties and good safety profile. Suc
Condensation Product of 4-Methoxybenzaldehyde and Ethylenediamine: “Off-On” Fluorescent Sensor for Cerium(III)
Das, Diganta Kumar,Bharali, Bidisha,Goyari, Swrangsi
, p. 1357 - 1361 (2018)
The condensation product (L) of 4-methoxybenzaldehyde and ethylenediamine has been synthesised and characterised. L showed a 21 times enhancement in fluorescence intensity on interaction with Ce3+ in CH3OH at λmax = 360?nm
Conformational and structural analysis of N-N′-bis (4-methoxybenzylidene)ethylenediamine
ünalero?lu,Temelli,H?kelek
, p. 91 - 95 (2001)
The Schiff base compound, N-N′-bis(4-methoxybenzylidene)ethylenediamine (C18H20N2O2) has been synthesized and its crystal structure has been investigated by X-ray analysis and PM3 method. The compound crystalliz
A new family of doubly cyclopalladated diimines. A remarkable effect of the linker between the metalated units on their cytotoxicity
Albert, Joan,Bosque, Ramon,Cadena, Magali,D'Andrea, Lucia,Granell, Jaume,Gonzalez, Asensio,Quirante, Josefina,Calvis, Carmen,Messeguer, Ramon,Badia, Josefa,Baldoma, Laura,Calvet, Teresa,Font-Bardia, Merce
, p. 2862 - 2873 (2014)
The cyclopalladation of a series of symmetric diimines with the formula (RC6H4CH=NZ)2, where Z = CH2 or (CH2)2OCH2 and R = p-Cl, p-OMe, p-NO 2, and o-Cl, is described. Optimal conditions to obtain the dimetalated compounds were found to be palladium(II) acetate, in toluene, at 60 °C and with a reaction time of 2-4 h. The reactivity of the dimetalated compounds with monodentate, bidentate, and bis(monodentate) Lewis bases was also studied. The cytotoxic activity of some selected compounds was evaluated against a panel of adenocarcinoma cell lines (colon HCT116 and breast MCF7 and MDA-MB231). Compounds containing the fragment NCH2CH 2OCH2CH2OCH2CH2N exhibited a remarkable cytotoxic activity in the three cancer cells assayed, but complexes containing the NCH2CH2N fragment showed no activity. It seems that the length and flexibility of the central saturated chain in the imine molecule, as well as its lipophilicity and hydrophilicity, explain the different cytotoxicity of the two series of coordination compounds here reported.
Design, synthesis and biological evaluation of Schiff’s base derivatives as multifunctional agents for the treatment of Alzheimer’s disease
Shi, Jian,Zhou, Yi,Wang, Keren,Ma, Qinge,Wei, Rongrui,Li, Qingfeng,Zhao, Yiyang,Qiao, Zhanpin,Liu, Shuang,Leng, Yumin,Liu, Wenmin,Sang, Zhipei
, p. 624 - 634 (2020/11/30)
A series of Schiff’s base derivatives was rationally designed, synthesized, and evaluated as multi-function agents for the treatment of Alzheimer’s disease (AD). The results revealed that compound 3b was a novel multifunctional agent. It acted as a highly selective monoamine oxidase-B inhibitor (IC50 = 8.4 nM), which was explained by the docking study. Compound 3b also was an antioxidant agent (2.3 eq) and could significantly inhibit self-induced Aβ1-42 aggregation (31.8%). Meanwhile, compound 3b was a selective metal chelator and could inhibit Cu2+-induced Aβ1-42 aggregation (62.3%). Furthermore, compound 3b presented good neuroprotective effects on H2O2-induced PC12 cell injury. More importantly, compound demonstrated good blood brain barrier permeability and druglike properties. Therefore, compound 3b, a promising multi-targeted active molecule, offers an attractive starting point for further study in the drug-discovery process against AD.[Figure not available: see fulltext.].
Phototriggered cytotoxic properties of tricarbonyl manganese(I) complexes bearing α-diimine ligands towards HepG2
Mansour, Ahmed M.,Radacki, Krzysztof,Khaled, Rabaa M.,Soliman, Marwa H.,Abdel-Ghani, Nour T.
, p. 135 - 147 (2021/03/06)
Reaction between bromo tricarbonyl manganese(I) and N,N′-bis(phenyl)-1,4-diaza-1,3-butadiene ligands, bearing different electron-donating and electron-withdrawing groups R?=?OCH3, Cl, and NO2 in the ortho- and para-positions on the p
Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1
Kishk, Safaa M.,McLean, Kirsty J.,Sood, Sakshi,Helal, Mohamed A.,Gomaa, Mohamed S.,Salama, Ismail,Mostafa, Samia M.,de Carvalho, Luiz Pedro S.,Munro, Andrew W.,Simons, Claire
supporting information, p. 1546 - 1561 (2019/03/05)
The rise in multidrug resistant (MDR) cases of tuberculosis (TB) has led to the need for the development of TB drugs with different mechanisms of action. The genome sequence of Mycobacterium tuberculosis (Mtb) revealed twenty different genes coding for cy
Design and application of diimine-based copper(i) complexes in photoredox catalysis
F?ldesi, Tamás,Sipos, Gellért,Adamik, Réka,Nagy, Bálint,Tóth, Balázs L.,Bényei, Attila,Szekeres, Krisztina J.,Láng, Gyz G.,Demeter, Attila,Peelen, Timothy J.,Novák, Zoltán
supporting information, p. 8343 - 8347 (2019/09/30)
Structurally different bis(imino)copper(i) complexes were prepared in a highly modular manner and utilized as copper-based photocatalysts in the ATRA reactions of styrenes and alkyl halides. The new photocatalysts showed good catalytic activity and ensured efficient chemical transformations.
