187143-22-2

Basic information

• Product Name: 6-(Methylsulfonyl)-3-pyridinamine
• Synonyms: 6-(Methylsulfonyl)-3-pyridinamine
• CAS NO: 187143-22-2
• Molecular Formula: C6H8N2O2S
• Molecular Weight: 172
• Mol File: 187143-22-2.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 6-(Methylsulfonyl)-3-pyridinamine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(Methylsulfonyl)-3-pyridinamine(187143-22-2)
• EPA Substance Registry System: 6-(Methylsulfonyl)-3-pyridinamine(187143-22-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 187143-22-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-(Methylsulfonyl)-3-pyridinamine is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new medicines.
Used in Agrochemical Industry:
6-(Methylsulfonyl)-3-pyridinamine is also utilized as an intermediate in the production of agrochemicals, indicating its role in the creation of agricultural products.
Used in Cancer Therapy Research:
6-(Methylsulfonyl)-3-pyridinamine is studied for its potential as an anti-tumor agent, due to its capacity to inhibit the cyclin-dependent kinase 9 (CDK9) enzyme, which plays a role in cancer cell proliferation.
Used in Anti-Inflammatory Applications:
6-(Methylsulfonyl)-3-pyridinamine has been investigated for its anti-inflammatory properties, suggesting a possible use in the treatment of inflammatory conditions.
Used in Enzyme Inhibition:
6-(Methylsulfonyl)-3-pyridinamine is recognized as a potent inhibitor of CDK9, which may lead to its use in the development of therapies targeting diseases related to enzyme dysregulation.

Upstream product

• 79134-11-5 3-Nitro-6-(methylsulfonyl)pyridine 
• 7439-89-6 iron 
• 20885-21-6 3-nitro-6-(methylthio)pyridine 
• 4548-45-2 2-chloro-5-nitropyridine 

Downstream Products

• 1198785-18-0 2-bromo-6-methanesulfonylpyridin-3-ylamine 
• 1156780-33-4 C₁₃H₁₄N₂O₂S 
• 1617508-26-5 N-(2,3-dimethoxybenzyl)-6-(methylsulfonyl)pyridin-3-amine 

Relevant articles and documents

METHODS OF USING INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS

This disclosure features the use of one or more indazole-3-carboxamide compounds or salts or analogs thereof, in the treatment of one or more diseases or conditions independently selected from the group consisting of a tendinopathy, dermatitis, psoriasis, morphea, ichthyosis, Raynaud's syndrome, and Darier's disease; and/or for promoting wound healing. The methods include administering to a subject (e.g., a subject in need thereof) a therapeutically effective amount of one or more indazole-3-carboxamide compounds or salts or analogs thereof as described anywhere herein.

5-SUBSTITUTED INDAZOLE-3-CARBOXAMIDES AND PREPARATION AND USE THEREOF

Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, fibrotic disorders, cartilage (chondral) defects, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, and neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

SUBSTITUTED PYRAZOLE ANALOGUES AS RAR ANTAGONISTS

The present invention provides compounds of Formula I or a pharmaceutical salt thereof; methods of treating osteoarthritis and the pain associated with osteoarthritis using the compounds; and processes for preparing the compounds.

INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS

lndazole-3-carboxamide compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole-3- carboxamide compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

Compounds of Formula I wherein R1, R2, X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

1,2,4-TRIAZOLE DERIVATIVE, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

A 1,2,4-triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided.

Acetylene derivatives as anti-inflammatory/analgesic agents

The present invention relates to compounds of the formula wherein R1, R2, R3, R4, R5, R6, X and Y are defined as in the specification, to pharmaceutical compositions containing them and to

Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents

The present invention relates to compounds of the formula wherein R2, R3, R6and A are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as osteoarthritis, rheumatoid arthritis, colon cancer and Alzheimer's disease, in mammals (preferably humans, dogs, cats and livestock).

Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents

This invention relates to a compound of the formula: or a pharmaceutically acceptable salt thereof, wherein A and R1are each an optionally substituted 5 to 6-membered heteroaryl, wherein the heteroaryl is optionally fused to a carbocyclic ring

Pyrazole ether derivatives as anti-inflammatory/analgesic agents

The present invention relates to compounds of the formula wherein R1, R2, R3, R4, R5, R6, R7, R8, A, X and Y are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer, and Alzheimer's disease in mammals, preferably humans, dogs, cats and livestock animals.