18730-23-9

Basic information

• Product Name: 2-(2,4-Dichlorophenyl)-4H-3,1-benzoxazin-4-one
• Synonyms: 2-(2,4-Dichlorophenyl)-4H-3,1-benzoxazin-4-one
• CAS NO: 18730-23-9
• Molecular Formula: C₁₄H₇Cl₂NO₂
• Molecular Weight: 292.12
• Mol File: 18730-23-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2,4-Dichlorophenyl)-4H-3,1-benzoxazin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-Dichlorophenyl)-4H-3,1-benzoxazin-4-one(18730-23-9)
• EPA Substance Registry System: 2-(2,4-Dichlorophenyl)-4H-3,1-benzoxazin-4-one(18730-23-9)

Safety Data

• Hazardous Substances Data: 18730-23-9(Hazardous Substances Data)

Usage

Physical form

White powder

Solubility

Insoluble in water, soluble in organic solvents

Pharmacological properties

Anti-inflammatory, antimicrobial

Potential uses

Cancer treatment, neurodegenerative disorder treatment

Other activity

Antioxidant

Possible applications

Development of new pharmaceuticals and therapeutic agents

Upstream product

• 118-92-3 anthranilic acid 
• 89-75-8 2,4-dichlorobenzoyl chloride 
• 551-93-9 2-aminoacetophenone 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 71936-93-1 N-(2,4-dichlorobenzylidene)anthranilic acid 

Relevant articles and documents

Selective Oxidative Decarbonylative Cleavage of Unstrained C(sp3)-C(sp2) Bond: Synthesis of Substituted Benzoxazinones

A transition metal (TM)-free practical synthesis of biologically relevant benzoxazinones has been established via a selective oxidative decarbonylative cleavage of an unstrained C(sp3)-C(sp2) bond employing iodine, sodium bicarbonate, and tbutyl hydroperoxide in DMSO at 95 °C. Control experiments and Density Functional Theory (DFT) calculations suggest that the reaction involves a [1,5]H shift and extrusion of CO gas as the key steps. The extrusion of CO has also been established using PMA-PdCl2.

Phl(OAc)2-mediated one-pot synthesis of benzoxazinones from anthranilic acids and aromatic aldehydes

A novel way to synthesise 2-aryl-4H-benzo[d][1,3]oxazin-4-ones has been developed by the cyclisation of Schiff bases with (diacetoxyiodo)benzene. The salient features of this new protocol which starts from an anthranilic acid and an aromatic aldehyde, are

HETEROCYCLIC COMPOUNDS REGULATING CLOTTING

Compounds of formula (I) as factor VII-tissue factor inhibitors as well as novel benzoxazin derivatives are disclosed, wherein R1, R2, R3, X and Y are as defined in the specification. These compounds, and pharmaceutically acceptable salts thereof, have be

A SIMPLE PREPARATION OF 2-ARYL-4H-3,1-BENZOXAZIN-4-ONES

Room temperature treatment of methyl N-acylanthranilates with concentrated sulfuric acid leads to 2-aryl-4h-3,1-benzoxazin-4-ones in excellent yield.