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CAS

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187480-15-5

Methyl 5-bromo-2-methoxy-6-(methylamino)nicotinate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 187480-15-5 Structure

  • Basic information

    1. Product Name: Methyl 5-bromo-2-methoxy-6-(methylamino)nicotinate
    2. Synonyms: Methyl 5-bromo-2-methoxy-6-(methylamino)nicotinate
    3. CAS NO:187480-15-5
    4. Molecular Formula: C9H11BrN2O3
    5. Molecular Weight: 275.09924
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 187480-15-5.mol

  • Chemical Properties

    1. Melting Point: 128-130°
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Methyl 5-bromo-2-methoxy-6-(methylamino)nicotinate(CAS DataBase Reference)
    10. NIST Chemistry Reference: Methyl 5-bromo-2-methoxy-6-(methylamino)nicotinate(187480-15-5)
    11. EPA Substance Registry System: Methyl 5-bromo-2-methoxy-6-(methylamino)nicotinate(187480-15-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 187480-15-5(Hazardous Substances Data)

187480-15-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 187480-15-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,7,4,8 and 0 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 187480-15:
(8*1)+(7*8)+(6*7)+(5*4)+(4*8)+(3*0)+(2*1)+(1*5)=165
165 % 10 = 5
So 187480-15-5 is a valid CAS Registry Number.

187480-15-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 5-bromo-2-methoxy-6-(methylamino)pyridine-3-carboxylate

1.2 Other means of identification

Product number -
Other names methyl 5-bromo-2-methoxy-6-methylaminopyridine-3-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:187480-15-5 SDS

187480-15-5Relevant articles and documents

A practical preparation of methyl 2-methoxy-6-methylaminopyridine-3-carboxylate from 2,6-dichloro-3-trifluoromethylpyridine

Horikawa,Hirokawa,Kato

, p. 1621 - 1627 (2007/10/03)

An effective and practical synthetic route to methyl 2-methoxy-6-methylaminopyridine-3-carboxylate (7), the key intermediate of 5-bromo-2-methoxy-6-methylaminopyridine-3-carboxylic acid (1), from 2,6-dichloro-3-trifluoromethylpyridine (12) was undertaken. Process improvements were highlighted by regioselectivity of 12 with a nitrogen nucleophile and conversion of the 3- trifluoromethyl group into the methoxycarbonyl group. The reaction of 12 with N-benzylmethylamine provided the 6-(N-benzyl-N-methyl)aminopyridine 26a and the regioisomer 26b in >98: 2 ratio in a quantitative yield. Treatment of 2-methoxy-6-methylamino-3-trifluoropyridine (14a) with a large excess of sodium methoxide followed by acid hydrolysis gave the pyridine-3-carboxylic ester 7 in an excellent yield. The potential application of this reaction is also described.

An efficient synthesis of 5-bromo-2-methoxy-6-methylaminopyridine-3-carboxylic acid

Hirokawa,Horikawa,Kato

, p. 1847 - 1853 (2007/10/03)

An efficient synthesis of 5-bromo-2-methoxy-6-methylaminopyridine-3-carboxylic acid (1), a carboxylic acid moiety of a potent dopamine D2 and D3 and serotonin-3 (5-HT3) receptors antagonist, (R)-5-bromo-N-(1-ethyl-4-methyl

(R)-5-bromo-N-(1-ethyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-2-methoxy-6-methylamino-3-pyridinecarboxamide, process for producing the same and medicinal composition containing the same

-

, (2008/06/13)

This invention discloses a compound which is expressed by formula (I) below: STR1 or physiologically acceptable acid addition salts thereof. The claimed compound exhibits excellent antiemetic effect based on its potent serotonin S3 and dopamine

Synthesis of N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6- yl)nicotinamides and their affinities for 5-HT3 and dopamine D2 receptors

Hirokawa, Yoshimi,Yoshida, Naoyuki,Kato, Shiro

, p. 1551 - 1554 (2007/10/03)

A series of N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)nicotinamide derivatives were prepared and evaluated for their binding to 5-HT3 and dopamine D2 receptors. Among them, the 5-bromo-2-methoxy-6- methylaminonicotinamide 16 and its (R)-isomer were found to have potent affinities for both receptors. The affinities of (R)-16 for 5-HT3 and dopamine D2 receptors are approximately 3-fold higher than those of the corresponding benzamide (R)-1 (IC50: 1.1 and 12 nM vs. 2.9 and 35 nM, respectively).

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