187657-92-7

Basic information

• Product Name: 1-(1-BENZOFURAN-3-YL)-2-BROMO-1-ETHANONE
• Synonyms: 1-(1-BENZOFURAN-3-YL)-2-BROMO-1-ETHANONE;1-(Benzofuran-3-yl)-2-bromoethan-1-one;2,4-Bis(methylsulfonyl)phenylhydrazine;(1-Benzofuran-3-yl)-2-bromo-1-ethanone;1-(1-benzofuran-3-yl)-2-broMoethan-1-one;1-(Benzofuran-3-yl)-2-broMoethanone
• CAS NO: 187657-92-7
• Molecular Formula: C₁₀H₇BrO₂
• Molecular Weight: 239.07
• EINECS: 260-718-7
• Product Categories: Furan&Benzofuran
• Mol File: 187657-92-7.mol

Chemical Properties

• Melting Point: 136 °C
• Boiling Point: 306.782 °C at 760 mmHg
• Flash Point: 139.337 °C
• Appearance: white to light yellow crystal powder
• Density: 1.583 g/cm³
• Vapor Pressure: 0.000755mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: 1-(1-BENZOFURAN-3-YL)-2-BROMO-1-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-BENZOFURAN-3-YL)-2-BROMO-1-ETHANONE(187657-92-7)
• EPA Substance Registry System: 1-(1-BENZOFURAN-3-YL)-2-BROMO-1-ETHANONE(187657-92-7)

Safety Data

• Hazard Codes: C,Xi
• Statements: 36/37/38-34
• Safety Statements: 26-36/37/39-45
• HazardClass: IRRITANT
• Hazardous Substances Data: 187657-92-7(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

InChI:InChI=1/C10H7BrO2/c11-5-9(12)8-6-13-10-4-2-1-3-7(8)10/h1-4,6H,5H2

Upstream product

• 66611-15-2 3-acetylbenzo[b]furan 
• 7789-45-9 copper(II)bromide 

Downstream Products

• 233671-42-6 4-acetylamino-3-(2'-oxo-2'-<3''-benzofuryl>-ethyl)-aminobenzoic acid t-butyl ester 
• 343614-12-0 (S)-(+)-(benzofuran-3-yl)oxirane 
• 877263-54-2 C₁₈H₁₇NO₂ 
• 66611-15-2 3-acetylbenzo[b]furan 
• 1187820-53-6 [3-[2-(Benzofuran-3-yl)imidazo[1,2-a]pyridin-6-yl]phenyl]methanol 
• 1300728-61-3 4-(2-((2-(benzofuran-3-yl)allyl)oxy)phenyl)-1H-imidazole 
• 1300731-10-5 C₃₉H₃₀N₂O₂ 
• 1300728-62-4 4-(2-(2-(benzofuran-3-yl)propoxy)phenyl)-1H-imidazole 
• 1300731-09-2 1-(benzofuran-3-yl)-2-(2-(1-trityl-1H-imidazol-4-yl)phenoxy)ethanone 

Relevant articles and documents

Baker's yeast-mediated synthesis of (R)- and (S)-heteroaryl-ethane-1,2-diols

Baker's yeast-mediated enantioselective bioreduction of 1-(heteroaryl)-2-hydroxyethanones and 2-acetoxy-1-(hetero-aryl)ethanones was used for the enantioselective synthesis of both (R)- and (S)-benzofuranyl-, benzo[b]thiophenyl- and benzo[d]thiazolyl-ethane-1,2-diols.

Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

The compounds of the present invention are represented by the chemical structure found in Formula (I): wherein: the carbon atom designated * is in the R or S configuration; and X is a fused bicyclic carbocycle or heterocycle selected from the group consisting of benzofuranyl, benzo[b]thiophenyl, benzoisothiazolyl, benzoisoxazolyl, indazolyl, indolyl, isoindolyl, indolizinyl, benzoimidazolyl, benzooxazolyl, benzothiazolyl, benzotriazolyl, imidazo[1,2-a]pyridinyl, pyrazolo[1,5-a]pyridinyl, [1,2,4]triazolo[4,3-a]pyridinyl, thieno[2,3-b]pyridinyl, thieno[3,2-b]pyridinyl, 1H-pyrrolo[2,3-b]pyridinyl, indenyl, indanyl, dihydrobenzocycloheptenyl, tetrahydrobenzocycloheptenyl, dihydrobenzothiophenyl, dihydrobenzofuranyl, indolinyl, naphthyl, tetrahydronaphthyl, quinolinyl, isoquinolinyl, 4H-quinolizinyl, 9aH-quinolizinyl, quinazolinyl, cinnolinyl, phthalazinyl, quinoxalinyl, benzo[1,2,3]triazinyl, benzo[1,2,4]triazinyl, 2H-chromenyl, 4H-chromenyl, and a fused bicyclic carbocycle or fused bicyclic heterocycle optionally substituted with substituents (1 to 4 in number) as defined in R14; with R1, R2, R3, R4, R5, R6, R7, R8, and R14 defined herein.

Enantioselective synthesis of 2- and 3-benzofuryl β-amino alcohols

Enantioselective reduction of 2- and 3-bromoacetylbenzofurans with (-)-B-chlorodiisopinocampheylborane produced the corresponding bromohydrins which were transformed into (S)-(benzofuran-2-yl)oxirane of 70% ee and (S)-(benzofuran-3-yl)oxirane of 71% ee, respectively. The epoxides treated with primary alkylamines gave the corresponding (S)-1-(benzofuran-2- and -3-yl)-2-(alkylamino) ethanols.

Condensed thiazole derivatives, having 5-HT receptor affinity

Compounds of formula I STR1 in which A is S(O) p or O;p is 0, 1 or 2;g is 0, 1, 2, 3, or 4;n is 2 or 3; andR 1, R 2, R 3, R 4 and R 5 are optional substituents have utility in the treatment of central nervous system disorders, for example depression, anxiety, psychoses (for example schizophrenia), tardive dyskinesia, obesity, drug addiction, drug abuse, cognitive disorders, Alzheimer''s disease, senile dementia, cerebral ischemia, obsessive-compulsive behavior, panic attacks, social phobias, eating disorders and anorexia, non-insulin dependent diabetes mellitus, hyperglycemia, and stress.