66611-15-2

Usage

Uses

Used in Pharmaceutical Industry:
3-Acetylbenzo[b]furan is used as a potential medicinal agent for its anti-inflammatory, anti-cancer, and neuroprotective properties. It is being studied for its ability to modulate various biological pathways and exert therapeutic effects in different health conditions.
Used in Laboratory Research:
3-Acetylbenzo[b]furan is used as a research compound in the development and testing of new pharmaceutical products. Its unique structure and potential medicinal properties make it a valuable tool for understanding the mechanisms of action and interactions with biological systems.
Used in Drug Development:
3-Acetylbenzo[b]furan is used as a lead compound in the design and synthesis of new drugs. Its chemical structure provides a foundation for the creation of novel therapeutic agents that can target specific diseases and conditions, with the aim of improving treatment outcomes and patient care.

InChI:InChI=1/C10H8O2/c1-7(11)9-6-12-10-5-3-2-4-8(9)10/h2-6H,1H3

Upstream product

• 74017-72-4 1-Dimethylaminomethylene-1-(2-methoxyphenyl)-2-propanone 
• 533-58-4 2-Iodophenol 
• 120568-94-7 O-prenyl-2-iodophenol 
• 33118-70-6 3-(1-Methylethyl)benzofuran 
• 270-75-7 isobenzofuran 
• 75-36-5 acetyl chloride 
• 530-47-2 N,N-diphenylhydrazine hydrochloride 
• 765-87-7 cyclohexane-1,2-dione 
• 5211-62-1 1-(2-methoxyphenyl)propan-2-one 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 214759-93-0 C₁₁H₁₁NO₃ 
• 75-16-1 methylmagnesium bromide 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 59214-70-9 3-bromobenzofuran 

Downstream Products

• 343614-13-1 (S)-(-)-1-(benzofuran-3-yl)ethanol 
• 343614-12-0 (S)-(+)-(benzofuran-3-yl)oxirane 
• 343614-11-9 (R)-1-Benzofuran-3-yl-2-bromo-ethanol 
• 187657-92-7 1-(benzofuran-3-yl)-2-bromoethane-1-one 
• 1088487-06-2 2-{benzo[b]furan-3-yl}ethanone phenylhydrazone 
• 1246308-85-9 12H-benzofuro[3,2-a]carbazole 
• 1338919-72-4 1,3-bis(12-(12H-benzofuranyl[3,2-a])carbazolyl)benzene 
• 1338919-77-9 2-benzofuran-3-yl-5-bromo-1H-indole 
• 1433220-37-1 2-(benzofuran-3-yl)-4-methylpent-4-en-2-ol 
• 1206485-75-7 2-tosyloxy-1-(3-benzofuranyl)ethanone 

Relevant academic research and scientific papers

Site-Specific Oxidation of (sp3)C-C(sp3)/H Bonds by NaNO2/HCl

A site-specific oxidation of (sp3)C-C(sp3) and (sp3)C-H bonds in aryl alkanes by the use of NaNO2/HCl was explored. The method is chemical-oxidant-free, transition-metal-free, uses water as the solvent, and proceeds under mild conditions, making it valuable and attractive to synthetic organic chemistry.

Metal Sulfonate Polymers as Catalysts for the Heterogeneous Acylation of Aromatic Derivatives

A series of metal sulfonate salts attached to a poly(ether ether ketone) (PEEK) polymer were prepared by ultrasonic activation and then examined as heterogeneous catalysts in the Friedel–Crafts acylation of aromatic derivatives.

SUBSTITUTED CARBAZOLE DERIVATIVES AND USE THEREOF IN ORGANIC ELECTRONICS

An organic light-emitting diode, organic solar cell or switching element comprising at least one substituted carbazole derivative of the general formula (I), (II) or (III) in which X is NR4, O, S or PR4;Y is NR5, O, S or PR5; where at least one of the symbols X and Y is NR4 or NR5; substituted carbazole derivatives of the formula (I), (II) or (III); a light-emitting layer comprising at least one substituted carbazole derivative of the general formula (I), (II) or (III) and at least one emitter material; the use of substituted carbazole derivatives of the general formula (I), (II) or (Ill) as matrix material, hole/exciton blocker material and/or electron/exciton blocker material and/or hole injection material and/or electron injection material and/or hole conductor material and/or electron conductor material in an organic light-emitting diode, an organic solar cell or in a switching element, and a device selected from the group consisting of stationary visual display units, mobile visual display units, illumination units, keyboards, garments, furniture and wallpaper comprising at least one inventive organic light-emitting diode.

SUBSTITUTED CARBAZOLE DERIVATIVES AND USE THEREOF IN ORGANIC ELECTRONICS

An organic light-emitting diode, organic solar cell or switching element comprising at least one substituted carbazole derivative of the general formula (I), (II) or (III) in which X is NR4, O, S or PR4; Y is NR5, O, S or PR5; where at least one of the symbols X and Y is NR4 or NR5; R1 and R3 are each independently substituted or unsubstituted C1-C20-alkyl, substituted or unsubstituted C6-C30-aryl, substituted or unsubstituted heteroaryl having 5 to 30 ring atoms or a substituent with donor or acceptor action selected from the group consisting of C1-C20-alkoxy, C6-C30-aryloxy, C1-C20-alkylthio, C6-C30-arylthio, SiR6R7R8, halogen radicals, halogenated C1-C20-alkyl radicals, carbonyl (-CO(R6)), carbonylthio (- C = O (SR6)), carbonyloxy (- C = O(OR6)), oxycarbonyl (- OC = O(R6)), thiocarbonyl (- SC = O(R6)), amino (-NR6R7), OH, pseudohalogen radicals, amido (- C = O (NR6)), -NR6C = O (R7), phosphonate (- P(O) (OR6)2), phosphate (-OP(O) (OR6)2), phosphine (-PR6R7), phosphine oxide (-P(0)R62), sulfate (-OS(0)2OR6), sulfoxide (-S(O)R6), sulfonate (-S(O)2OR6), sulfonyl (-S(O)2R6), sulfonamide (-S(O)2NR6R7), N02, boronic esters (-OB(OR6)2), imino (-C = NR6R7), borane radicals, stannane radicals, hydrazine radicals, hydrazone radicals, oxime radicals, nitroso groups, diazo groups, vinyl groups, sulfoximines, alanes, germanes, boroximes and borazines;

Chemoenzymatic synthesis of (R)- and (S)-1-heteroarylethanols

A chemoenzymatic methodology for the synthesis of highly enantiomerically enriched (S)- and (R)-1-heteroarylethanols by enantioselective bioreduction with baker's yeast of the corresponding 1-heteroarylethanones followed by three racemization free chemical steps including a Mitsunobu reaction was developed.

4-(Heteroaryl-methyl and substituted heteroaryl-methyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists

Compounds of Formula 1 where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors. Additionally some of the claimed compounds have no or only minimal cardivascular and/or sedatory activity. The compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2 adrenergic receptors. Compounds of Formula 1 which have no significant cardiovascular and/or sedatory activity are useful for treating pain and other conditions with minimal side effects.

Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

The compounds of the present invention are represented by the chemical structure found in Formula (I): wherein: the carbon atom designated * is in the R or S configuration; and X is a fused bicyclic carbocycle or heterocycle selected from the group consisting of benzofuranyl, benzo[b]thiophenyl, benzoisothiazolyl, benzoisoxazolyl, indazolyl, indolyl, isoindolyl, indolizinyl, benzoimidazolyl, benzooxazolyl, benzothiazolyl, benzotriazolyl, imidazo[1,2-a]pyridinyl, pyrazolo[1,5-a]pyridinyl, [1,2,4]triazolo[4,3-a]pyridinyl, thieno[2,3-b]pyridinyl, thieno[3,2-b]pyridinyl, 1H-pyrrolo[2,3-b]pyridinyl, indenyl, indanyl, dihydrobenzocycloheptenyl, tetrahydrobenzocycloheptenyl, dihydrobenzothiophenyl, dihydrobenzofuranyl, indolinyl, naphthyl, tetrahydronaphthyl, quinolinyl, isoquinolinyl, 4H-quinolizinyl, 9aH-quinolizinyl, quinazolinyl, cinnolinyl, phthalazinyl, quinoxalinyl, benzo[1,2,3]triazinyl, benzo[1,2,4]triazinyl, 2H-chromenyl, 4H-chromenyl, and a fused bicyclic carbocycle or fused bicyclic heterocycle optionally substituted with substituents (1 to 4 in number) as defined in R14; with R1, R2, R3, R4, R5, R6, R7, R8, and R14 defined herein.

Enantioselective synthesis of 2- and 3-benzofuryl β-amino alcohols

Enantioselective reduction of 2- and 3-bromoacetylbenzofurans with (-)-B-chlorodiisopinocampheylborane produced the corresponding bromohydrins which were transformed into (S)-(benzofuran-2-yl)oxirane of 70% ee and (S)-(benzofuran-3-yl)oxirane of 71% ee, respectively. The epoxides treated with primary alkylamines gave the corresponding (S)-1-(benzofuran-2- and -3-yl)-2-(alkylamino) ethanols.

Condensed thiazole derivatives, having 5-HT receptor affinity

Compounds of formula I STR1 in which A is S(O) p or O;p is 0, 1 or 2;g is 0, 1, 2, 3, or 4;n is 2 or 3; andR 1, R 2, R 3, R 4 and R 5 are optional substituents have utility in the treatment of central nervous system disorders, for example depression, anxiety, psychoses (for example schizophrenia), tardive dyskinesia, obesity, drug addiction, drug abuse, cognitive disorders, Alzheimer''s disease, senile dementia, cerebral ischemia, obsessive-compulsive behavior, panic attacks, social phobias, eating disorders and anorexia, non-insulin dependent diabetes mellitus, hyperglycemia, and stress.