- Rhodium(III)-catalyzed N-nitroso-directed C-H olefination of arenes. High-yield, versatile coupling under mild conditions
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N-Nitroso compounds are a versatile class of organic structures that allow expedient access to a diversity of synthetically useful architectures through demonstrated reactivities. We report herein the development of a Rh(III)-catalyzed N-nitroso-directed
- Liu, Baoqing,Fan, Yang,Gao, Yang,Sun, Chao,Xu, Cheng,Zhu, Jin
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p. 468 - 473
(2013/02/23)
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- SUBSTITUTED BENZOLACTAM COMPOUNDS
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This invention relates to compounds of general formula (I): or a pharmaceutically acceptable salt thereof, W, T, Y, X, Q, R, R, and R are defined herein. This invention also relates to compounds of formula (I), depicted above, wherein Y is -NH-; T is (2S,3S)-2-phenylpiperidin-3-yl, where the phenyl group of said (2S, 3S)-2-phenylpiperidine-3-yl may optionally be substituted with fluoro; Q is oxygen and is double bonded to the carbon atom to which it is attached, X is methoxy or ethoxy, R is hydrogen, methyl or halo-C1-C2 alkyl, W is methylene, ethylene or vinylene; R and R are independently hydrogen or methyl, or one of R or R may be hydroxy, when W is ethylene, R and R are both methyl, when W is methylene, and R and R are both hydrogen, when W is vinylene. The invention is further directed to methods of treating various CNS and other disorders using said compounds and pharmaceutical compositions thereof.
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- Substituted benzolactam compounds as substance P antagonists
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Compounds of the formula are effective for the treatment of conditions in mammals which require inhibition of the action of substance P.
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- Synthesis of tetrahydroquinolines, hexahydrobenzoindolizines and an aryl phosphonate linker for the generation of catalytic antibodies
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Syntheses of 6-methoxy-1-methyl-1,2,3,4-tetrahydroquinoline-3-methanol 10 and 1,2,3,5,6,10b-hexahydrobenzo[g]indolizine-6-methanol 34 are described. The aryl phosphonic acid 14, which can be used as a linker to a protein, is synthesised and coupled to the above alcohols. These haptens, when linked to a protein, are intended to generate antibodies able to catalyse cationic cyclisation reactions.
- Gonzalez-Bello, Concepcion,Abell, Chris,Leeper, Finian J.
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p. 1017 - 1024
(2007/10/03)
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