187679-62-5

Basic information

• Product Name: 6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline
• Synonyms: 6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline;6-Methoxy-1-methyl-3,4-dihydroquinolin-2(1H)-one
• CAS NO: 187679-62-5
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.22642
• Mol File: 187679-62-5.mol

Chemical Properties

• Boiling Point: 427.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.139±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.92±0.20(Predicted)
• CAS DataBase Reference: 6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline(187679-62-5)
• EPA Substance Registry System: 6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline(187679-62-5)

Safety Data

• Hazardous Substances Data: 187679-62-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure and properties make it a valuable component in the development of new drugs targeting a range of diseases.
Used in Agrochemical Industry:
In the agrochemical sector, 6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline serves as a fundamental building block for the creation of novel agrochemicals. Its incorporation into these products can enhance their effectiveness in agricultural applications.
Used in Antioxidant Applications:
6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline is utilized as an antioxidant, helping to combat oxidative stress and related conditions. Its antioxidant properties make it a promising candidate for the development of treatments aimed at reducing oxidative damage in various diseases.
Used in Anti-Inflammatory Applications:
6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline is also used for its anti-inflammatory properties, which can be beneficial in the management of inflammation-related disorders. Its potential to reduce inflammation makes it a candidate for inclusion in therapeutic agents for such conditions.

Upstream product

• 5392-11-0 6-Methoxy-1-methyl-2-oxo-1,2-dihydroquinoline 
• 940-11-4 N-methyl-N-nitroso-p-anisidine 
• 5961-59-1 N-methyl-N-(4-methoxyphenyl)amine 
• 1416897-52-3 (E)-methyl 3-(5-methoxy-2-(methyl(nitroso)amino)phenyl)acrylate 
• 21979-59-9 6-methoxy-(N-methyl-quinolinium iodide) 
• 5263-87-6 6-methoxy quinoline 

Downstream Products

• 187679-81-8 6-Methoxy-1-methyl-2-thioxo-1,2,3,4-tetrahydroquinoline 
• 189886-33-7 (E)-3-{4-[Hydroxy-(6-methoxy-1-methyl-1,2,3,4-tetrahydro-quinolin-3-ylmethoxy)-phosphoryl]-phenyl}-acrylic acid isopropyl ester 

Relevant articles and documents

Rhodium(III)-catalyzed N-nitroso-directed C-H olefination of arenes. High-yield, versatile coupling under mild conditions

N-Nitroso compounds are a versatile class of organic structures that allow expedient access to a diversity of synthetically useful architectures through demonstrated reactivities. We report herein the development of a Rh(III)-catalyzed N-nitroso-directed

SUBSTITUTED BENZOLACTAM COMPOUNDS

This invention relates to compounds of general formula (I): or a pharmaceutically acceptable salt thereof, W, T, Y, X, Q, R, R, and R are defined herein. This invention also relates to compounds of formula (I), depicted above, wherein Y is -NH-; T is (2S,3S)-2-phenylpiperidin-3-yl, where the phenyl group of said (2S, 3S)-2-phenylpiperidine-3-yl may optionally be substituted with fluoro; Q is oxygen and is double bonded to the carbon atom to which it is attached, X is methoxy or ethoxy, R is hydrogen, methyl or halo-C1-C2 alkyl, W is methylene, ethylene or vinylene; R and R are independently hydrogen or methyl, or one of R or R may be hydroxy, when W is ethylene, R and R are both methyl, when W is methylene, and R and R are both hydrogen, when W is vinylene. The invention is further directed to methods of treating various CNS and other disorders using said compounds and pharmaceutical compositions thereof.

Substituted benzolactam compounds as substance P antagonists

Compounds of the formula are effective for the treatment of conditions in mammals which require inhibition of the action of substance P.

Synthesis of tetrahydroquinolines, hexahydrobenzoindolizines and an aryl phosphonate linker for the generation of catalytic antibodies

Syntheses of 6-methoxy-1-methyl-1,2,3,4-tetrahydroquinoline-3-methanol 10 and 1,2,3,5,6,10b-hexahydrobenzo[g]indolizine-6-methanol 34 are described. The aryl phosphonic acid 14, which can be used as a linker to a protein, is synthesised and coupled to the above alcohols. These haptens, when linked to a protein, are intended to generate antibodies able to catalyse cationic cyclisation reactions.