940-11-4

Basic information

• Product Name: 4-methoxy-N-methyl-N-nitrosoaniline
• CAS NO: 940-11-4
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.1772
• Mol File: 940-11-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 318.7°C at 760 mmHg
• Flash Point: 146.5°C
• Density: 1.1g/cm³
• Vapor Pressure: 0.000355mmHg at 25°C
• Refractive Index: 1.52
• CAS DataBase Reference: 4-methoxy-N-methyl-N-nitrosoaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-N-methyl-N-nitrosoaniline(940-11-4)
• EPA Substance Registry System: 4-methoxy-N-methyl-N-nitrosoaniline(940-11-4)

Safety Data

• Hazardous Substances Data: 940-11-4(Hazardous Substances Data)

Upstream product

• 701-56-4 4-methoxy-N,N-dimethylanilne 
• 7647-01-0 hydrogenchloride 
• 5961-59-1 N-methyl-N-(4-methoxyphenyl)amine 
• 110-46-3 isopentyl nitrite 
• 104-94-9 4-methoxy-aniline 
• 544-16-1 n-Butyl nitrite 

Downstream Products

• 219325-56-1 ethyl 5-methoxy-1-methyl-2-phenyl-1H-indole-3-carboxylate 
• 64648-52-8 5-methoxy-1,3-dimethyl-2-phenyl-1H-indole 
• 127473-29-4 5-methoxy-1-methyl-2,3-diphenyl-1H-indole 
• 187679-62-5 6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline 
• 1416897-78-3 (E)-methyl 3-(5-methoxy-2-(methylamino)phenyl)acrylate 
• 1416897-52-3 (E)-methyl 3-(5-methoxy-2-(methyl(nitroso)amino)phenyl)acrylate 
• 76137-90-1 [Pd((C₆H₃OCH₃-4)N(NO)CH₃)Cl(PPh₃)2] 
• 110516-03-5 1,2-dimethyl-6-(toluene-4-sulfonyloxy)-3,4-dihydro-1H-benz[cd]indol-5-one 
• 59908-54-2 <(5-methoxy-1-methyl)indol-2-yl>carboxylic acid 
• 17591-06-9 5-methoxy-1,2-dimethyl-1H-indole 
• 2731-01-3 (±)-5-methoxy-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo-[2,3-b]indole 

Relevant articles and documents

Rhodium(iii)-catalyzed indole synthesis at room temperature using the transient oxidizing directing group strategy

Rh-catalyzed reactions of N-alkyl anilines with internal alkynes at room temperature have been developed using an in situ generated N-nitroso group as a transient oxidizing directing group. Due to mild reaction conditions, this method enabled synthesis of a broad range of N-alkyl indoles, including even two indole-based medicinal compounds. Our work disclosed the feasibility of the transient oxidizing directing group strategy in C-H functionalization reactions, which possesses the potential to enhance overall step-economy and impart new reactivity patterns to substrates.

Novel nitrosation polymer in organic synthesis

The present invention relates to a novel nitrosation polymer of the formula in which X, Y, R1, R2 and R3 are as defined in claim 1. The invention also relates to a process for the preparation of the said polymer.

N-Dealkylation-N-nitrosation of Tertiary Aromatic Amines by n-Butyl Nitrite

N,N-Dialkyl aromatic amines with a variety of ring substituents are N-dealkylated and N-nitrosated efficiently by n-butyl nitrite/ammonium chloride/water at reflux temperature.Ring nitrosation was never observed, but minor amounts of m- and p-nitro amines and/or nitrosamines were formed in some cases.Ring nitration is rather a reaction of the initial substrate than a process occurring on formed nitrosamines.The leaving propensities of the initial N-substituents to yield nitrosamines were in the order benzyl >> methyl >> alkyl.Key Words: Nitrosamines; N-Dealkylation; N-Nitrosation; C-Nitration; Alkyl nitrite.