188048-45-5Relevant articles and documents
Total synthesis of endothelin-converting enzyme antagonist WS75624 B
Huang, Sheng-Tung,Gordon, Dana M.
, p. 9335 - 9338 (1998)
A concise synthesis of endothelin-converting enzyme antagonist WS75624 B is reported. The natural product was prepared in seven steps from 2,4- dibromothiazole.
Synthesis of novel substituted pyridines as inhibitors of endothelin converting enzyme-1 (ECE-1)
Massa, Mark A.,Patt, William C.,Ahn, Kyunghye,Sisneros, Andre M.,Herman, Sarah B.,Doherty, Annette
, p. 2117 - 2122 (2007/10/03)
A series of bi-aryl pyridine carboxylic acids has been prepared and evaluated as inhibitors of ECE-1. The analogs were prepared by Pd catalyzed cross couplings of halogenated pyridines with heteroaryl organo -boranes, - tinate or -zincate derivatives.
The total synthesis of the natural product endothelin converting enzyme (ECE) inhibitor, WS75624 B
Patt, William C.,Massa, Mark A.
, p. 1297 - 1300 (2007/10/03)
The first total synthesis of WS75624 B, 1, an endothelin converting enzyme inhibitor produced in a fermentation broth of Saccharothrix sp. No. 75624 is reported herein. WS75624 B is synthesized in 14 steps from commercially available kojic acid, 2. The synthetic methodology allows for facile substitution at multiple sites on the molecule.