188724-68-7Relevant articles and documents
Design, synthesis and biological investigation of certain pyrazole-3-carboxylic acid derivatives as novel carriers for nitric oxide
Abdel-Hafez, El-Shimaa M.N.,Abuo-Rahma, Gamal El-Din A.A.,Abdel-Aziz, Mohamed,Radwan, Mohamed F.,Farag, Hassan H.
experimental part, p. 3829 - 3837 (2009/10/02)
Some novel pyrazole-NO hybrid molecules 5a-e, 6, 8 and 10 were prepared through binding of the pyrazole-3-carboxylic acid derivatives with nitric oxide donor moiety like oxime or nitrate ester. The prepared compounds were evaluated for nitric oxide release, antibacterial and anti-inflammatory activities. The organic nitrate 10 exhibited the highest percentage of NO release using Griess diazotization method. Some of the prepared compounds exhibited remarkable antibacterial activity against Escherichia coli C-600, Pseudomonas aeruginosa, Bacillus subitilis and Staphylococcus aureus NCTC 6571 compared to ciprofloxacin. Most of the tested compounds showed significant anti-inflammatory activity compared to indomethacine using carrageenan induced paw edema method. In general, structural modification of compound 2 either to nitrate ester or oxime hybrids showed better anti-inflammatory with less ulcerogenic liability than their corresponding starting intermediates.
Functionalization and Cyclization Reactions of 4-Benzoyl-1,5-diphenyl- 1H-pyrazole-3-carboxylic Acid
Akcamur, Yunus,Sener, Ahmet,Ipekoglu, Alemdar Mustafa,Kollenz, Gert
, p. 221 - 224 (2007/10/03)
The 1H-pyrazole-3-carboxylic acid 2 or its remarkably stable acid chloride 3 can easily be converted into the corresponding ester or amide derivatives 4 or 5, respectively, from reaction with alcohols or N-nucleophiles. Pyrazolo[3,4-d]pyridazines 6a,b are obtained from cyclocondensation reactions of the pyrazoles 2 and 3, respectively, with phenylhydrazine or hydrazine hydrate, while 6c is formed in an one-pot procedure from the furan-2,3-dione 1 and hydrazine hydrate.
