18952-87-9

Basic information

• Product Name: 1-Isopropylpyrazole
• Synonyms: 1-isopropylpyrazole;1-(1-Methylethyl)-1H-pyrazole;1-Isopropyl-1H-pyrazole;2-isopropyl-1H-Pyrazole;1-propan-2-ylpyrazole;1-(propan-2-yl)-1H-pyrazole
• CAS NO: 18952-87-9
• Molecular Formula: C₆H₁₀N₂
• Molecular Weight: 110.16
• Product Categories: API intermediates
• Mol File: 18952-87-9.mol

Chemical Properties

• Boiling Point: 143 °C
• Flash Point: 43 °C
• Appearance: /
• Density: 0.96
• Vapor Pressure: 6.833mmHg at 25°C
• Refractive Index: 1.4620 to 1.4660
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.29±0.10(Predicted)
• CAS DataBase Reference: 1-Isopropylpyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Isopropylpyrazole(18952-87-9)
• EPA Substance Registry System: 1-Isopropylpyrazole(18952-87-9)

Safety Data

• RIDADR: UN 1993 3/PG III
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 18952-87-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
1-Isopropylpyrazole is used as a building block for the synthesis of pharmaceuticals, contributing to the development of new drugs with potential therapeutic applications.
Used in Agricultural Chemicals:
1-Isopropylpyrazole is used as a precursor in the synthesis of agricultural chemicals, aiding in the creation of effective compounds for pest control and crop protection.
Used in Coordination Chemistry:
1-Isopropylpyrazole is used as a ligand in coordination chemistry, facilitating the formation of coordination compounds with potential applications in catalysis, materials science, and medicinal chemistry.
Used in Material Development:
1-Isopropylpyrazole is used in the development of new materials, leveraging its versatile chemistry to create innovative substances with unique properties and potential applications in various industries.
Used in Anti-inflammatory Applications:
1-Isopropylpyrazole is used as an anti-inflammatory agent, potentially mitigating inflammation and related symptoms in various conditions.
Used in Anti-cancer Applications:
1-Isopropylpyrazole is used as an anti-cancer agent, showing promise in the inhibition of tumor growth and progression, and potentially enhancing the efficacy of conventional chemotherapeutic drugs.

InChI:InChI=1/C6H10N2/c1-6(2)8-5-3-4-7-8/h3-6H,1-2H3

Upstream product

• 288-13-1 NH-pyrazole 
• 75-26-3 isopropyl bromide 
• 75-30-9 2-iodo-propane 

Downstream Products

• 839714-33-9 [1-(propan-2-yl)-1H-pyrazol-5-yl]boronic acid 
• 313350-82-2 4-iodo-N-isopropyl-1H-pyrazole 
• 313735-67-0 1-(propan-2-yl)-1H-pyrazole-4-carbaldehyde 
• 839714-37-3 3-(2-isopropyl-2H-pyrazol-3-yl)-4-methoxy-phenylamine 
• 839714-34-0 1-isopropyl-5-(2-methoxy-5-nitrophenyl)-1H-pyrazole 
• 839714-35-1 3-(4-chloro-2-isopropyl-2H-pyrazol-3-yl)-4-methoxy-phenylamine 
• 839714-31-7 3-(4-bromo-2-isopropyl-2H-pyrazol-3-yl)-4-methoxyphenylamine 

Relevant articles and documents

Pyrazole N-alkylation method

The invention provides a pyrazole N-alkylation method. Pyrazole or pyrazole derivatives and alkyl halogenated hydrocarbons react in a solvent under the existence of quaternary ammonium salt catalysts;N-alkyl substituted pyrazole is obtained. The method provided by the invention has the advantages that the operation is simple; the cost is low; the anhydrous oxygen-free environment is not needed; heating is not needed; the yield is high; the amplified industrialized production can be easily realized.

NEW THIENOPYRIMIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R12, X, A and n are as defined in the description.

Synthesis of heterocyclic compounds from 4-formylpyrazoles

Formylation of pyrazole and 2,5-dimethylpyrazole gave a number of pyrazole-containing aldehydes, which can be used to obtain chromenes, tetrahydrochromenes, 1,4-dihydropyrano[2,3-c]pyrazoles, pyrano[3,2-c]chromenes, thiochromeno[4,3-b]pyrans, pyrano[3,2-c

Discovery of 1-[3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxyphenyl]-3-(2, 4-difluorophenyl)urea (Nelotanserin) and Related 5-Hydroxytryptamine 2A Inverse Agonists for the Treatment of Insomnia

Insomnia affects a growing portion of the adult population in the U.S. Most current therapeutic approaches to insomnia primarily address sleep onset latency. Through the 5-hydroxytryptamine2A (5-HT2A) receptor, serotonin (5-HT) plays a role in the regulation of sleep architecture, and antagonists/ inverse-agonists of 5-HT2A have been shown to enhance slow wave sleep (SWS). We describe here a series of 5-HT2A inverse-agonists that when dosed in rats, both consolidate the stages of NREM sleep, resulting in fewer awakenings, and increase a physiological measure of sleep intensity. These studies resulted in the discovery of 1-[3-(4-bromo-2- methyl-2i/-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (Nelotanserin), a potent inverse-agonist of 5-HT2A that was advanced into clinical trials for the treatment of insomnia.

Pyrazole-substituted arylamides as P2X3 and P2X2/3 antagonists

Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted pyrazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.

1H-QUINAZ0LINE-2,4-DIONES AND THEIR USE AS AMPA-RECEPTOR LIGANDS

The present invention relates to l H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as AMPA-receptor ligands, in particular for the treatment of epilepsy or schizophrenia, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) and combinations comprising compounds of formula (I) are disclosed.

DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERTO

The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to