19013-11-7

Basic information

• Product Name: 4-METHYL-3-NITROBENZAMIDE
• Synonyms: 3-NITRO-4-METHYLBENZAMIDE;4-METHYL-3-NITROBENZAMIDE;4-methyl-3-nitro-benzamid;3-NITRO-4-METHYLBENZOYL AMINE
• CAS NO: 19013-11-7
• Molecular Formula: C₈H₈N₂O₃
• Molecular Weight: 180.16
• EINECS: 242-752-4
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 19013-11-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 164-165°C
• Boiling Point: 291.7 °C at 760 mmHg
• Flash Point: 130.2 °C
• Appearance: /
• Density: 1.322 g/cm³
• Vapor Pressure: 0.00192mmHg at 25°C
• Refractive Index: 1.599
• BRN: 2102644
• CAS DataBase Reference: 4-METHYL-3-NITROBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-3-NITROBENZAMIDE(19013-11-7)
• EPA Substance Registry System: 4-METHYL-3-NITROBENZAMIDE(19013-11-7)

Safety Data

• Statements: 22
• Safety Statements: 22-36/37
• RIDADR: 2811
• TSCA: Yes
• PackingGroup: III
• Hazardous Substances Data: 19013-11-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4-METHYL-3-NITROBENZAMIDE is used as a building block for the synthesis of other chemical compounds, playing a crucial role in the development of new organic molecules.
Used in Pharmaceutical Industry:
4-METHYL-3-NITROBENZAMIDE is used as a precursor in the synthesis of pharmaceutical compounds, contributing to the discovery and development of new drugs.
Used in Agrochemical Industry:
4-METHYL-3-NITROBENZAMIDE is used as a starting material for the production of agrochemicals, such as pesticides and herbicides, to improve crop protection and yield.
Used in Materials Science:
4-METHYL-3-NITROBENZAMIDE is used as a component in the development of new materials with specific properties, such as polymers, coatings, and adhesives.
Used as a Reagent in Chemical Reactions:
4-METHYL-3-NITROBENZAMIDE is used as a reagent to facilitate various chemical reactions, enabling the synthesis of target compounds and improving reaction efficiency.
Used as a Precursor for Synthesis of Organic Compounds:
4-METHYL-3-NITROBENZAMIDE is used as a precursor in the synthesis of a wide range of organic compounds, including intermediates and final products in various chemical processes.

InChI:InChI=1/C8H8N2O3/c1-5-2-3-6(8(9)11)4-7(5)10(12)13/h2-4H,1H3,(H2,9,11)

Upstream product

• 96-98-0 4-methyl-3-nitrobenzoic acid 
• 501-89-3 4-(carboxymethyl)benzoic acid 
• 41252-97-5 4-iodo-2-nitrotoluene 
• 444667-11-2 2-(4-carboxy-2-nitrophenyl)-acetic acid 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 104-85-8 para-methylbenzonitrile 
• 619-55-6 para-methylbenzamide 
• 939-79-7 4-cyano-2-nitrotoluene 

Downstream Products

• 623155-50-0 C₁₁H₁₂N₂O₄ 
• 623155-52-2 C₁₁H₁₂N₂O₅ 
• 623155-51-1 C₁₁H₁₄N₂O₃ 
• 623155-49-7 C₁₁H₁₄N₂O₂ 
• 623154-45-0 C₂₂H₂₆N₆O₄ 
• 623154-44-9 C₂₂H₂₆N₆O₃ 
• 1401624-08-5 C₉H₆N₂O₄ 
• 836684-57-2 N-dimethylaminomethylene-4-methyl-3-nitro-benzamide 
• 61599-56-2 2-nitro-trans-stilbene-carboxylic acid-⁽⁴⁾-amide 
• 16533-71-4 3,5-dinitro-p-toluic acid 

Relevant articles and documents

Palladium on manganese ferrite: An efficient catalyst for one pot synthesis of primary amides from iodobenzene

Amidation of aryl iodide in one pot is reported using Pd-MnFe2O4 as a catalyst. The catalyst was characterized by various techniques such as XRD, FEG-SEM, EDS, TEM, BET surface area and ICP AES. K4[Fe(CN)6]is used as a non toxic cyanation reagent for in situ generation of benzonitrile and hydrolyzed as soon as it formed. The catalyst was found to be efficient and can be used for several cycles without loss in activity. Good to excellent yields of primary amides were obtained.

1-(PIPERIDIN-4-YL)-1H-INDOLE DERIVATIVE

The present invention provides a compound represented by the formula (1) or a pharmacologically acceptable salt thereof, or a hydrate thereof (provided that a compound in which all of R4a, R4b, and R4c are hydrogen atoms is excluded.): [wherein R1 represents a hydrogen atom, R2 represents a hydrogen atom, R3 represents the formula: wherein R4a, R4b, and R4c are the same as or different from each other and each represents a hydrogen atom, a C1-6 alkyl group or a C1-6 alkoxy group, etc.]

Indole derivative having piperidine ring

The present invention relates to a compound represented by the following formula, a pharmacologically acceptable salt thereof, or a use thereof as a pharmaceutical: wherein R1 and R2 are substituents adjacent to each other, and together with two carbon atoms to each of which they attach, form a 5- to 7-membered non-aromatic carbocyclic group or the like, which may be substituted by 1 to 4 substituents selected from (1) an oxo group, (2) a hydroxyl group, and the like; R3 represents a hydrogen atom or the like; and R6 represents a hydrogen atom or the like. It is an object of the present invention to discover an agent for treating or preventing lower urinary tract symptoms, and particularly symptoms regarding urinary storage, which has a superior strength of binding to a 5-HT1A receptor and an antagonism to the receptor.

Labelled compounds of interest as antitumour agents - VI. Isotopically efficient syntheses of [15N]-nitrothiophenecarboxamides

Reaction of 3-cyanothiophene with one equivalent of potassium nitrate in concentrated sulphuric acid causes nitration, concurrent with hydrolysis of the nitrile, to give 5-nitro-thiophene-3-carboxamide in high yield. Similarly, 2-cyanothiophene gives 4-nitro-thiophene-2-carboxamide and 5-nitrothiophene-2-carboxamide, benzonitrile gives 3-nitrobenzamide and 4-methylbenzonitrile gives 4-methyl-3-nitrobenzamide. Extension of this process to use of potassium [15N]-nitrate, formed from [15N]-nitric acid (95% isotopic enrichment), enables preparation of the corresponding [15N]-nitrothiophenecarboxamides in high isotopic yield.