- Ammonia as Ultimate Amino Source in Synthesis of Primary Amines via Nickel-Promoted C-H Bond Amination
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The direct use of ammonia in transition-metal promoted C-H bond amination for the synthesis of primary amines is considered to be one of the major challenges in synthetic organic chemistry. Herein, we report that such transformation can be successfully ac
- Yu, Lin,Yang, Chan,Yu, Yongqi,Liu, Da,Hu, Liang,Xiao, Yuanjiu,Song, Ze-Nan,Tan, Ze
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- Highly selective mild stepwise allylation of N-methoxybenzamides with allenes
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An efficient Rh(III)-catalyzed stepwise ortho allylation of N-methoxybenzamides 1 with polysubstituted allenes is reported. This C-H functionalization involving allenes is conducted under very mild conditions (-20 °C or room temperature) and compatible wi
- Zeng, Rong,Fu, Chunling,Ma, Shengming
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supporting information; experimental part
p. 9597 - 9600
(2012/07/14)
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- Novel yellow phosphorescent iridium complexes containing a carbazole-oxadiazole unit used in polymeric light-emitting diodes
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Yellow iridium complexes Ir(PPOHC)3 and (PPOHC) 2Ir(acac) (PPOHC: 3-(5-(4-(pyridin-2-yl)phenyl)-1,3,4-oxadiazol-2-yl) -9-hexyl-9H-carbazole) were synthesized and characterized. The Ir(PPOHC) 3 complex has good thermal stability with 5% weight-reduction occurring at 370 °C and a glass-transition temperature of 201 °C. A polymeric light-emitting diode using the Ir(PPOHC)3 complex as a phosphorescent dopant showed a luminance efficiency of 16.4 cd/A and the maximum external quantum efficiency of 6.6% with CIE coordinates of (0.50, 0.49). A white polymeric light-emitting diode was fabricated using Ir(PPOHC)3 which showed a luminance efficiency of 15.3 cd/A, with CIE coordinates of (0.39, 0.44). These results indicate that the iridium complexes containing a linked carbazole-oxadiazole unit are promising candidates in high-efficiency electroluminescent devices.
- Tang, Huaijun,Li, Yanhu,Wei, Caihong,Chen, Bing,Yang, Wei,Wu, Hongbin,Cao, Yong
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p. 413 - 421
(2012/06/18)
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- BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)
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A compound having the structure set forth in Formula (I) or Formula (II): wherein the variables Y, R1, R2, R3, and R4 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.
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Page/Page column 73
(2009/08/16)
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- Azapeptide derivatives as HIV protease inhibitors
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This invention relates to novel compounds of the Formula Ib: that are azapeptides, and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel azapeptide compounds that are derivatives of the HIV protease inhibitor atazanavir sulfate. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and a carrier, and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administering HIV protease inhibitors. The invention also relates to the use of one or more of the disclosed compounds as reagents in analytical studies involving atazanavir.
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Page/Page column 20; 35; 37
(2009/01/24)
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- MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF
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The present invention relates to compounds with α7 nAChR agonistic activity, processes for their preparation, pharmaceutical compositions containing the same and the use thereof for the treatment of neurological, psychiatric, cognitive, immunological and inflammatory disorders.
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Page/Page column 25-26; 34-35
(2010/02/15)
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- Amides that inhibit vanilloid receptor subtype 1 (VR1) receptor
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The present invention relates to compounds of formula (I) that are novel VR1 antagonists useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence, or bladder overactivity.
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- N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl}arylcarboxamides as novel dopamine D3 receptor antagonists
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The dopamine D3 receptor subtype has been targeted as a potential neurochemical modulator of the behavioral actions of psychomotor stimulants, such as cocaine. Previous synthetic studies provided structural requirements for high affinity bindin
- Newman, Amy Hauck,Cao, Jianjing,Bennett, Christina J.,Robarge, Michael J.,Freeman, Rebekah A.,Luedtke, Robert R.
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p. 2179 - 2183
(2007/10/03)
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