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191089-59-5

K-7174 is a synthetic chemical compound that functions as a potent and selective inhibitor of the enzyme farnesyl protein transferase (FPTase). This enzyme is crucial for the post-translational modification of proteins by adding a farnesyl group, a process implicated in the development of certain cancers. By inhibiting FPTase, K-7174 can potentially prevent the activation of proteins that contribute to cancer growth and progression, positioning it as a promising anti-cancer agent.

191089-59-5

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  • 1,4-bis[(4E)-5-(3,4,5-trimethoxyphenyl)pent-4-en-1-yl]-1,4-diazepane

    Cas No: 191089-59-5

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191089-59-5 Usage

Uses

Used in Pharmaceutical Industry:
K-7174 is used as an anti-cancer agent for its ability to inhibit the farnesyl protein transferase enzyme, which is involved in the development of certain types of cancer. By blocking the enzyme, K-7174 can suppress tumor growth and progression, as demonstrated in animal models, making it a candidate for further development in cancer treatment.
Used in Cancer Research:
In the field of cancer research, K-7174 is utilized to study the role of FPTase in cancer development and to explore the potential of inhibiting this enzyme as a therapeutic strategy. This research can provide insights into the molecular mechanisms of cancer and contribute to the development of new cancer treatments.
Used in Drug Development:
K-7174 serves as a lead compound in drug development programs aimed at creating new medications for the treatment of cancer. Its selectivity for FPTase and demonstrated efficacy in suppressing tumor growth make it a valuable starting point for the design and optimization of novel therapeutic agents targeting this enzyme.

Check Digit Verification of cas no

The CAS Registry Mumber 191089-59-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,1,0,8 and 9 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 191089-59:
(8*1)+(7*9)+(6*1)+(5*0)+(4*8)+(3*9)+(2*5)+(1*9)=155
155 % 10 = 5
So 191089-59-5 is a valid CAS Registry Number.

191089-59-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,4-bis((E)-5-(3,4,5-trimethoxyphenyl)pent-4-enyl)-1,4-diazepane

1.2 Other means of identification

Product number -
Other names N,N'-bis-((E)-5-(3,4,5-trimethoxyphenyl)-4-pentenyl)homopiperazine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:191089-59-5 SDS

191089-59-5Related news

Suppression of cytokine response by GATA inhibitor K-7174 (cas 191089-59-5) via unfolded protein response07/16/2019

K-7174, a GATA-specific inhibitor, is a putative anti-inflammatory agent that attenuates effects of inflammatory cytokines in certain cell types. However, molecular mechanisms involved have not been elucidated. We found that, in glomerular podocytes, induction of monocyte chemoattractant protein...detailed

191089-59-5Relevant articles and documents

A straightforward synthesis of K-7174, a GATA-specific inhibitor

Majik, Mahesh S.,Yu, Jin Ha,Jeong, Lak Shin

, p. 2903 - 2906 (2012/10/29)

K-7174, a GATA-specific inhibitor, is a putative anti-inflammatory agent that attenuates effects of inflammatory cytokines in certain cell types. An expeditious four-step synthesis of K-7174 is described in this paper. The route employs Wittig olefination

Inhibitors for cell adhesion and cellular infiltration

-

, (2008/06/13)

The present invention is directed to a cell adhesion inhibitory agent, cellular infiltration inhibitory agent, antiallergic agent, antiasthmatic agent, and antiphlogistic, which contains a compound of the following formula (1): STR1 wherein each of R

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