- Pyrazoline analogs as potential anticancer agents and their apoptosis, molecular docking, MD simulation, DNA binding and antioxidant studies
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N-formyl pyrazoline derivatives (3a–3l) were designed and synthesized via Michael addition reaction through cyclization of chalcones with hydrazine hydrate in presence of formic acid. The structural elucidation of N-formyl pyrazoline derivatives was carri
- Rana, Manish,Arif, Rizwan,Khan, Faez Iqbal,Maurya, Vikas,Singh, Raja,Faizan, Md Imam,Yasmeen, Shama,Dar, Sajad Hussain,Alam, Raquib,Sahu, Ankita,Ahmad, Tanveer,Rahisuddin
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- Characterization of the Fluorescence Properties of 4-Dialkylaminochalcones and Investigation of the Cytotoxic Mechanism of Chalcones
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Understanding the mechanisms responsible for the various biological activities of chalcones, particularly the direct cellular targets, presents an unmet challenge. Here, we prepared a series of fluorescent chalcone derivatives as chemical probes for their
- Zhou, Bo,Jiang, Peixin,Lu, Junxuan,Xing, Chengguo
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p. 539 - 552
(2016/08/26)
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- Novel benzothiazole based sulfonylureas/sulfonylthioureas: Design, synthesis and evaluation of their antidiabetic potential
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In the present study, twenty-eight benzothiazole based sulfonylureas/sulfonylthioureas were synthesized and were assessed for their antidiabetic effect in a normoglycemic rat model by the in vivo oral glucose tolerance test (OGTT). All the synthesized com
- Kharbanda, Chetna,Alam, Mohammad Sarwar,Hamid, Hinna,Javed, Kalim,Bano, Sameena,Ali, Yakub,Dhulap, Abhijeet,Alam, Parwez,Pasha
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p. 6777 - 6786
(2016/08/10)
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- Monoamine Oxidase Inhibitory Activity: Methyl- versus Chlorochalcone Derivatives
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Numerous studies have shown that chalcones are promising scaffolds for the development of new monoamine oxidase-B (MAO-B) inhibitors. As a continuation of our ongoing research into the development of reversible human MAO-B (hMAO-B) inhibitors, two series
- Mathew, Bijo,U?ar, Gülberk,Mathew, Githa Elizabeth,Mathew, Sincy,Kalatharakkal Purapurath, Praseedha,Moolayil, Fasil,Mohan, Smrithy,Varghese Gupta, Sheeba
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p. 2649 - 2655
(2016/12/23)
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- Synthesis and evaluation of pyrazolines bearing benzothiazole as anti-inflammatory agents
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The present study aims at the synthesis of pyrazolines bearing benzothiazole and their evaluation as anti-inflammatory agents. The synthesized compounds were evaluated for their anti-inflammatory potential using carrageenan induced paw edema model. Two co
- Kharbanda, Chetna,Alam, Mohammad Sarwar,Hamid, Hinna,Javed, Kalim,Bano, Sameena,Dhulap, Abhijeet,Ali, Yakub,Nazreen, Syed,Haider, Saqlain
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p. 5804 - 5812
(2015/02/02)
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- Synthesis and anti bacterial and anti-ulcer evaluation of new s-mannich bases of 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-thiones
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The synthesis of title compounds were accomplished by synthetic sequence shown in Scheme 1. Chalcones on cyclocondensation with thiourea in ethanol and potassium hydroxide under reflux yielded the respective dihydropyramidin-2(1H)- thiones. Each of the di
- Kodhati, Venkateshwarlu,Vanga, Malla Reddy,Yellu, Narsimha Reddy
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p. 234 - 240
(2013/07/26)
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- Microwave assisted synthesis and antibacterial activity of chalcone derivatives
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Chalcone derivatives have been synthesized by equimolar reactions between substituted aldehydes and substituted acetophenones in basic medium by using conventional and microwave assisted technique. These compounds are characterized by FTIR and 1H NMR spectra. Before characterization purity of these compounds has been checked by thin-layer chromatography method. These synthesized compounds have been screened for their antibacterial (E. coli, S. aureus) activities in different concentrations. The results showed that the chalcone derivatives are better at inhibiting growth of both types of bacteria (Gram negative and Gram positive) compared to chloramphenicol.
- Yadav, Khushbu,Sharma, Abha,Srivastava, J. N.
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p. 5779 - 5781,3
(2020/09/14)
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- Design, synthesis and evaluation of chalcone derivatives as anti- Inflammatory, antioxidant and antiulcer agents
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In the present study, a series of chalcone derivatives were designed based on QSAR analysis. The designed compounds were synthesized by Claisen Schmidt condensation and evaluated for anti-inflammatory, antioxidant and antiulcer activities. The results of
- Choudhary, Alka N.,Kumar, Arun,Juyal, Vijay
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experimental part
p. 479 - 488
(2012/08/08)
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- Analgesic and antimicrobial studies of some 2,4-dichloro-5-fluorophenyl containing arylidenetriazolothiadiazines
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2,4-Dichloro-5-fluorophenyl containing 7-arylidenetriazolothiadiazines were obtained by the reaction of 4-amino-3-(2,4-dichloro-5-fluorophenyl)-5-mercapto- 1,2,4-triazole with 2,3-dibromo-1,3-diarylpropan-1-ones, and also by the reaction of 4-amino-3-(2,4
- Karthikeyan, Mari S.,Holla, Bantwal S.,Shenoy, Shalini
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scheme or table
p. 707 - 716
(2009/07/25)
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- Syntheses of 1,5-benzothiazepines: Part XXIV - Syntheses of 4-(4-chlorophenyl)-2-(4-dimethyl-aminophenyl)-2,5-dihydro-8-substituted-1,5-benz othiazepines
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Single step syntheses of 4-(4-chlorophenyl)-2-(4-dimethylaminophenyl)-2,5-dihydro-8-substituted-1,5-benzo thiazepines have been achieved by the reactions of five 5-substituted-2-uminobenzenethiols with 4-dimethyl aminobenzal-4'-chloroacetophenone in ethanol saturated with HCl gas. The structural assignments of the final products are based on the results of elemental analyses, IR, 1H NMR and mass spectral studies.
- Pant, Umesh C.,Singhal, Babita,Sati, Meha,Pant, Seema
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