191595-63-8

Basic information

• Product Name: 2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINICACID
• Synonyms: 3-carboxyl-6-trifluoromethyl-1H-pyridin-2-one;2-Hydroxy-6-triflroromethylnicotinic acid;2-Hydroxy-6-(trifluoromethyl)nicotinic acid;2-Hydroxy-6-triflroroMethyl-3-pyridinecarboxylic acid;2-Hydroxy-6-(trifluoromethyl)pyridine-3-carboxylic acid, 3-Carboxy-2-hydroxy-6-(trifluoromethyl)pyridine;2-oxo-6-(trifluoromethyl)-1H-pyridine-3-carboxylic acid;2-Hydroxy-6-(trifluromethyl)nicotinicacid
• CAS NO: 191595-63-8
• Molecular Formula: C7H4F3NO3
• Molecular Weight: 207.11
• EINECS: 1312995-182-4
• Product Categories: Carboxylic Acids;Pyridines;Carboxylic Acids;carboxylic acid
• Mol File: 191595-63-8.mol

Chemical Properties

• Melting Point: 165-167°C
• Boiling Point: 372.484 °C at 760 mmHg
• Flash Point: 179.072 °C
• Appearance: /
• Density: 1.629 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.512
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINICACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINICACID(191595-63-8)
• EPA Substance Registry System: 2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINICACID(191595-63-8)

Safety Data

• Hazardous Substances Data: 191595-63-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINICACID is used as a key intermediate in the synthesis of various pharmaceuticals due to its unique structural features that facilitate the creation of new drug molecules with potential therapeutic applications.
Used in Agrochemical Development:
In the agrochemical industry, 2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINICACID is utilized as a building block for the development of new agrochemicals, leveraging its structural properties to enhance crop protection and yield.
Used in Medicinal Chemistry Research:
2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINICACID is employed as a subject of study in medicinal chemistry for its potential antioxidant and anti-inflammatory properties, with the aim of discovering new therapeutic agents that can address various health conditions.
Used in Drug Development:
As a compound with demonstrated chelating capabilities, 2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINICACID is used in drug development to explore its potential in creating medications that can target metal ion imbalances associated with certain diseases.

InChI:InChI=1/C7H4F3NO3/c8-7(9,10)4-2-1-3(6(13)14)5(12)11-4/h1-2H,(H,11,12)(H,13,14)

Upstream product

• 116548-03-9 2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide 
• 144740-55-6 1,2-dihydro-2-oxo-6-(trifluoromethyl)pyridine-3-carboxylic acid methyl ester 
• 231291-22-8 6-trifluoromethylnicotinic acid 
• 116548-03-9 2-hydroxy-6-trifluoromethylpyridine-3-carboxamide 

Downstream Products

• 144740-55-6 methyl 2-hydroxy-6-(trifluoromethyl)nicotinate 
• 144740-56-7 methyl 2-bromo-6-(trifluoromethyl)nicotinate 
• 917396-37-3 [2-methoxy-6-(trifluoromethyl)pyridin-3-yl]methanol 
• 917396-36-2 methyl 2-methoxy-6-(trifluoromethyl)nicotinate 

Relevant articles and documents

A tautomeric ligand enables directed C-H hydroxylation with molecular oxygen

Hydroxylation of aryl carbon-hydrogen bonds with transition metal catalysts has proven challenging when oxygen is used as the oxidant. Here, we report a palladium complex bearing a bidentate pyridine/ pyridone ligand that efficiently catalyzes this reaction at ring positions adjacent to carboxylic acids. Infrared, x-ray, and computational analysis support a possible role of ligand tautomerization from monoanionic (L,X) to neutral (L,L) coordination in the catalytic cycle of aerobic carbon-hydrogen hydroxylation reaction. The conventional site selectivity dictated by heterocycles is overturned by this catalyst, thus allowing late-stage modification of compounds of pharmaceutical interest at previously inaccessible sites.

GHRELIN O-ACYLTRANSFERASE INHIBITORS

This invention relates to novel compounds according to Formula (I) which are inhibitors of ghrelin O-acyltransferase (GOAT), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment

PYRIDINECARBOXAMIDES, USEFUL-PLANT-PROTECTING COMPOSITION COMPRISING THEM AND PROCESSES FOR THEIR PREPARTION AND THEIR USE

Compounds of the formula (I), or salts thereof, in which R1 to R4 are as defined in formula (I) of claim 1 are suitable as useful-plant-protecting agents for reducing or preventing harmful effects of agrochemicals on the useful plants and their method of preparation are described.

ACYLATED SPIROPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS

Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.