191730-78-6

Basic information

• Product Name: 7-Benzyloxyindoline
• Synonyms: 7-Benzyloxyindoline
• CAS NO: 191730-78-6
• Molecular Formula: C₁₅H₁₅NO
• Molecular Weight: 225.2857
• Mol File: 191730-78-6.mol

Chemical Properties

• Melting Point: 128-129℃
• Appearance: /
• CAS DataBase Reference: 7-Benzyloxyindoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Benzyloxyindoline(191730-78-6)
• EPA Substance Registry System: 7-Benzyloxyindoline(191730-78-6)

Safety Data

• Hazardous Substances Data: 191730-78-6(Hazardous Substances Data)

Upstream product

• 74864-81-6 7-benzyloxy-2-indolinone 
• 6855-54-5 3-benzyloxy-2-nitrophenyl-acetic acid 
• 20289-27-4 7-benzyloxyindole 

Downstream Products

• 1070956-18-1 N-(7-benzyloxy-2,3-dihydro-indole-1-carbothioyl)-benzamide 
• 1371593-14-4 C₂₃H₁₉NO₂ 
• 1371592-97-0 C₂₄H₂₄N₂O 
• 1371592-98-1 C₂₈H₂₆N₄O₂ 
• 1371592-99-2 C₂₈H₂₈N₄O₅ 
• 1371593-24-6 C₂₁H₂₈N₂O₃ 
• 6882-72-0 Spegazzinin, 3-Hydroxy-17-demethyl-(-)-aspidospermin 
• 88198-98-5 aspidospermine 
• 466-49-9 aspidospermine 

Relevant articles and documents

Effect of C7-substitution of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines on the selectivity towards a subclass of histone deacetylases

This study focused on the substitution effect at position C7 of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines. Compound 9, (E)-3-(7-amino-1-(4-methoxyphenylsulfonyl)indolin-5-yl)-N-hydroxyacrylamide, displayed 4- to 14-fold more potent antiproliferative

Design and synthesis of indole, 2,3-dihydro-indole, and 3,4-dihydro-2H-quinoline-1-carbothioic acid amide derivatives as novel HCV inhibitors

An efficient synthetic methodology to provide indole, 2,3-dihydro-indole, and 3,4-dihydro-2H-quinoline-1-carbothioic acid amide derivatives is described. These conformationally restricted heterobicyclic scaffolds were evaluated as a novel class of HCV inhibitors. Introduction of an acyl group at the NH2 of the thiourea moiety has been found to enhance inhibitory activity. The chain length and the position of the alkyl group on the indoline aromatic ring markedly influenced anti-HCV activity. The indoline scaffold was more potent than the corresponding indole and tetrahydroquinoline scaffolds and analogue 31 displayed excellent activity (EC50 = 510 nM) against HCV without significant cytotoxicity (CC50 >50 μM).

Phenylaminopropanol derivatives and methods of their use

The present invention is directed to phenylaminopropanol derivatives of formulae I, II, and III: [image] or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromyalgia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, schizophrenia, and combinations thereof.

Process for preparing N-benzyl indoles

A process for producing a compound of the formu5la STR1 comprising the step of reacting a compound of the formula STR2 with a compound of the formula STR3 to form a compound of the formula STR4 wherein R2a is selected from the groups recited ab