- Isopropylation of m-cresol over mesoporous Al-MCM-41 molecular sieves
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A study on the isopropylation of m-cresol with isopropyl alcohol was carried out utilizing Al-MCM-41 molecular sieves with Si/Al ratios of 59:1, 103:1, and 202:1 at 250°-400°C. The products obtained were 2-isopropyl-5-methylphenol (IMP), isopropyl-3-methylphenyl ether (IMPE), and isopropyl-(2-isopropyl-5-methylphenyl) ether (IIMPE). The m-cresol conversion increased till 300°C, after which it decreased. The selectivity of 2-isopropyl-5-methylphenol (IMP) was more than that of the other products. Of the three catalysts studied for isopropylation of m-cresol with isopropyl alcohol in the vapor phase, AI-MCM-41 (59) was more suitable than Al-MCM-41 (103) and Al-MCM-41 (202). The feed ratio of 1:2 was more suitable for better conversion and 100% selectivity to IMP. The study of time on stream indicates the retention of activity even after 10 hr with the feed ratio of 1:4 for nearly 10% conversion. Al-MCM-41 could be a convenient and ecofriendly alternative to the hazardous and highly corrosive mineral acid catalysts for m-cresol isopropylation.
- Murugesan,Umamaheswari,Palanichamy
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- 2DCOR-GC: An application of the generalized two-dimensional correlation analysis as a route to optimization of continuous flow supercritical fluid reactions
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A new approach for optimization and monitoring of continuous reactions has been developed using 2D correlation methods for the analysis of GC data (2DCOR-GC). 2DCOR-GC maps are obtained following perturbation of the system that allow the effect of changing reaction parameters such as time, temperature, pressure, or concentration to be both monitored and sequenced with regard to changes in the raw GC data. In this paper, we describe the application of the 2DCOR-GC technique to monitoring the reverse water-gas shift reaction in scCO2. 2DCOR-GC is combined with FT-IR data to validate the methodology. We also report the application of 2DCOR-GC to probe the mechanism of the alkylation of m-cresol with isopropyl alcohol in scCO2 using Nafion SAC-13 as the catalyst. These results identify coeluting peaks that could easily be missed without exhaustive method development.
- Hyde, Jason R.,Bourne, Richard A.,Noda, Isao,Stephenson, Phil,Poliakoff, Martyn
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- A novel route to produce thymol by vapor phase reaction of m-cresol with isopropyl acetate over Al-MCM-41 molecular sieves
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Mesoporous Al-MCM-41 (Si/Al = 55 and 104) and Al,Zn-MCM-41 (Si/(Al+Zn)=52) molecular sieves were synthesized hydrothermally. The materials were characterized by XRD, TGA, TPD (pyridine), ICP-AES, nitrogen sorption, and FT-IR techniques. The catalytic performance of these materials was examined in the vapor phase alkylation of m-cresol with isopropyl acetate. The products obtained were thymol, isothymol, 2-isopropyl-5-methylphenyl acetate (2-I-5-MPA), and isopropyl-3-methylphenyl ether (I-3-MPE). The time-on-stream study was carried out over Al-MCM-41(55) at 300°C and WHSV 1.52 h-1 wherein optimum conversion of m-cresol and selectivity to thymol were obtained. The dependence of activity and selectivity on the acid sites and hydrophobic and hydrophilic properties of the catalysts is discussed.
- Shanmugapriya,Palanichamy,Arabindoo, Banumathi,Murugesan
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- Compound with 6H-dibenzofuran structure and preparation method of compound
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The invention discloses a compound with a 6H-dibenzofuran structure and a preparation method of the compound, and belongs to the technical field of medicine synthesis. The technical scheme includes that the structural formula of the compound with the 6H-dibenzofuran structure is as shown in the specification. The compound is simple in synthesis process and low in cost, activity tests show that prepared FSH (follicle-stimulating hormone) antagonists have good effects on FSH receptors, and the compound is expected to be further popularized and applied.
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Paragraph 0020; 0026
(2017/08/29)
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- Selective alkylation of m-cresol with isopropyl alcohol under solvent-free conditions
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The outcome of the solvent free alkylation of m-cresol with isopropyl alcohol over strong acid resin catalyst has been investigated under microwave irradiation as well as conventional heating. The various reaction parameters like catalyst amount, mole rat
- Teodorescu, Florina,Enache, Adrian,Sandulescu, Madalina
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- INHIBITORS OF ACETYL-COA CARBOXYLASE
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The present invention relates to compounds that act as acetyl-CoA carboxylase (ACC) inhibitors. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
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Page/Page column 39
(2010/11/17)
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- Practical synthesis of aromatic ethers by SNAr of fluorobenzenes with alkoxides
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Aromatic fluorines have been substituted by alkoxides in a variety of activated and unactivated aromatic systems.
- Rodriguez, Juan R.,Agejas, Javier,Bueno, Ana B.
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p. 5661 - 5663
(2007/10/03)
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- New Oxidative Aromatization of α,β-Unsaturated Cyclohexenones with Iodine-Cerium(IV) Ammonium Nitrate in Alcohol
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The reaction of 2-cyclohexen-1-one derivatives with iodine-cerium(IV) ammonium nitrate in alcohols (methanol, ethanol, 1-propanol, 2-propanol, and 1-butanol) under refluxing, gave the corresponding alkyl phenyl ethers in good yields.In the case of diol (ethylene glycol, 1,3-propanediol, and 1,4-butanediol), phenoxyalkanol derivatives were obtained.The present method was also applicable to oxidative rearrangement of isophorone.
- Horiuchi, C. Akira,Fukunishi, Hirotada,Kajita, Mika,Yamaguchi, Akihisa,Kiyomiya, Hiroshi,Kiji, Shinji
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p. 1921 - 1924
(2007/10/02)
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- Synthesis of Substitued Dibenzophospholes. Part 6. Preparation of Symmetrical and Non-symmetrical Quaterphenyl Intermediates
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Further examples are given of the synthetic approach to 4,6-diaryldibenzophospholes by arylation of 1,3-dinitrobenzene and coupling of the resulting biphenyls to symmetrically substituted quaterphenyls.Satisfactory procedures are described for the monoarylation of 2,2',4,4'-tetranitrobiphenyl and for arylation of the products to provide non-symmetrically substituted tetranitroquaterphenyls.Some procedures for the regioselective alkoxydenitration of tetranitroquaterphenyls are described.
- Cornforth, Sir John,Kumar, Ashok,Stuart, Alan S.
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p. 859 - 866
(2007/10/02)
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- Arylation of Dialkyl Ethers by Gaseous Phenylium Ions. Formation and Behaviour of Dialkylphenyloxonium Ions in the Gas Phase
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Tritiated phenylium ions, obtained in the gas phase from the spontaneous decay of 1,4-ditritiobenzene, have been allowed to react with dialkyl ethers (MeOPrn, MeOPri, and PriOPrn) in the pressure range 20-400 Torr and in the presence of a thermal radical scavenger (O2, 4 Torr).The effects of a gaseous base (NH3, 4 Torr) on the reaction carried out at the highest pressure were also investigated.Singlet phenylium ion confirms its distinct affinity toward the n-centre of the substrate (ca. 80percent for MeOPr), although significant insertion into the alkyl groups of PriOPrn is observed as well.The stability and reactivity features of the formed dialkylphenyloxonium ions, under the experimental conditions chosen, have been studied as well as their fragmentation and isomerization mechanism.The behaviour of dialkylphenyloxonium ions in the gas state (20-400 Torr) is consistent with previous mechanistic hypotheses from mass spectrometric studies, carried out at much lower pressures (below 1 Torr).
- Fornarini, Simonetta,Speranza, Maurizio
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p. 171 - 178
(2007/10/02)
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