193158-96-2

Basic information

• Product Name: L-Glutamine, N2-acetyl-, radical ion(1-) (9CI)
• Synonyms: L-Glutamine, N2-acetyl-, radical ion(1-) (9CI)
• CAS NO: 193158-96-2
• Molecular Formula: C7H12N2O4
• Molecular Weight: 188.18
• Mol File: 193158-96-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: L-Glutamine, N2-acetyl-, radical ion(1-) (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: L-Glutamine, N2-acetyl-, radical ion(1-) (9CI)(193158-96-2)
• EPA Substance Registry System: L-Glutamine, N2-acetyl-, radical ion(1-) (9CI)(193158-96-2)

Safety Data

• Hazardous Substances Data: 193158-96-2(Hazardous Substances Data)

Upstream product

• 56-85-9 L-glutamine 
• 108-24-7 acetic anhydride 
• 71989-20-3 N₂-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine 
• 64-19-7 acetic acid 
• 56-85-9 GLUTAMINE 
• 75-36-5 acetyl chloride 
• 5817-08-3 Acetyl-D,L-glutaminsaeure 
• 23513-73-7 N-Acetyl-DL-glutaminsaeure-3-dimethylaminoethyl-ester 

Downstream Products

• 56159-64-9 methyl 2-acetamido-5-amino-5-oxopentanoate 

Relevant articles and documents

Aceglutamide and its injection and preparation method

The invention relates to the field of medicinal preparation, and provides aceglutamide, a preparation method thereof, an aceglutamide injection and a preparation method for the injection. According to the preparation of the aceglutamide, acetic anhydride is replaced by acetyl chloride, so that the reaction speed is accelerated, the time is shortened, the yield is greatly improved, and the yield reaches over 95 percent. During the preparation process of the compound provided by the invention, activated carbon is not required to be added; absorption loss is reduced; the treating process is simplified; the cost is reduced; the obtained compound is a new crystal; the clinical application effect is more ideal. Meanwhile, specific improvement is made for the preparation method for the aceglutamide injection, the conventional preparation method from thick preparation to diluted preparation is changed into one-step preparation, so that material preparation process is simplified; the preparation time is shortened; the temperature of the water used for preparing the injection is controlled, so that the levels of related materials of a product are effectively controlled. The preparation with higher quality can be obtained, and the medication safety of a patient is ensured.

A fundamental study of amadori rearrangement products in reducing sugar-amino acid model system by electrospray ionization mass spectrometry and computation

It is crucial to characterize Amadori rearrangement products (ARPs) formed in the early stage of Maillard reaction, one of the most important modifications in food science. We setup a reaction model system using six selected amino acids (arginine, asparagines, glutamine, histamine, lysine and tryptophan) and their N-terminal acetylated forms with different reducing sugars for a fundamental study of Amadori rearrangement products. The effects on forming Amadori rearrangement products were studied by using electrospray ionization mass spectrometry (ESI-MS). The reaction rate was affected by reaction temperature, reaction time, property of sugars and amino acids and the fragmentation mechanism of Amadori rearrangement products was illustrated by tandem MS (MS2) with collision-induced dissociation. The proposed fragmentation mechanism of Amadori rearrangement products in MS2 was provided based on MS2 data and it was supported by their computational data of density functional theory (DFT) at the B3LYP/6-31++G(d,p) level.

Acetylation under ultrasonic conditions: Convenient preparation of N-acetylamino acids

An efficient and simple method of preparation of acetylamino acids from amino acids under ultrasonic conditions is described. The reactions proceed without racemization and the yields are almost quantitative.