19444-23-6

Basic information

• Product Name: Benzyl 2-Hydroxy-2-Methylpropionate
• Synonyms: Benzyl 2-Hydroxy-2-Methylpropionate;Benzyl 2-hydroxy-2-methylpropanoate
• CAS NO: 19444-23-6
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.22706
• Mol File: 19444-23-6.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Benzyl 2-Hydroxy-2-Methylpropionate(CAS DataBase Reference)
• NIST Chemistry Reference: Benzyl 2-Hydroxy-2-Methylpropionate(19444-23-6)
• EPA Substance Registry System: Benzyl 2-Hydroxy-2-Methylpropionate(19444-23-6)

Safety Data

• Hazardous Substances Data: 19444-23-6(Hazardous Substances Data)

Usage

Uses

Benzyl 2-Hydroxy-2-methylpropionate is a useful chemical in organic synthesis.

Upstream product

• 594-61-6 2-methyllactic acid 
• 100-51-6 benzyl alcohol 
• 993-48-6 α-Hydroxy-2-methylpropionic acid Na salt 
• 100-44-7 benzyl chloride 
• 2495-37-6 benzyl methacrylate 
• 100-39-0 benzyl bromide 
• 7051-34-5 cyclopropylcarbinyl bromide 
• 13027-88-8 2-hydroxyisobutyramide 
• 7285-83-8 2,4,6-tris(benzyloxy)-1,3,5-triazine 

Downstream Products

• 2495-37-6 benzyl methacrylate 
• 1000296-72-9 α-ethoxy-isobutyric acid benzyl ester 
• 77140-20-6 5,5-dimethyl-4-benzyloxy-[5H]furan-2-one 
• 1159999-13-9 benzyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate 
• 1370712-60-9 C₁₉H₂₂O₅ 
• 1370712-61-0 benzyl 2-[3-(methoxymethoxy)phenoxy]-2-methylpropanoate 
• 1370712-62-1 C₁₉H₂₂O₅ 
• 1370712-63-2 C₂₀H₂₄O₅ 
• 1370712-58-5 benzyl 2-methyl-2-(3-methylphenoxy)propionate 
• 1370712-56-3 C₁₇H₁₈O₃ 
• 1370712-59-6 C₁₈H₂₀O₃ 
• 1370712-57-4 C₁₈H₂₀O₃ 
• 1428848-57-0 1-(benzyloxy)-2-methyl-1-oxopropan-2-yl 4-(N-(tert-butoxycarbonyl)methylsulfonamido)-3-(cyclopropylmethoxy)benzoate 

Relevant articles and documents

Synthesis and Applications of Unquaternized C-Bound Boron Enolates

A general and facile method to prepare unquaternized C-bound boron enolates by a ligand-controlled O-to-C isomerization is reported. Using this protocol, C-bound pinacolboron enolates have been isolated in pure form for the first time, and have been fully characterized by NMR spectroscopy and X-ray crystallography. In contrast to the general perception, such C-boron enolates are stable without coordinative saturation at the boron. Moreover, C-boron enolates present reactivities that are distinct from the O-boron enolates, and their applications in C-O and C-C bond formations are demonstrated.

O-Benzylation of Carboxylic Acids Using 2,4,6-Tris(benzyloxy)-1,3,5-triazine (TriBOT) under Acidic or Thermal Conditions

Two methods for the synthesis of benzyl esters from carboxylic acids using the O-benzylating reagent 2,4,6-tris(benzyloxy)-1,3,5-triazine (TriBOT) have been developed. The reactions were conducted either in the presence of a catalytic amount of TfOH at room temperature (acidic conditions) or in the absence of TfOH at 180-230 C (thermal conditions). Interestingly, the O-benzylation of hydroxy carboxylic acids under the two conditions afforded different products: The dibenzylated product under acidic conditions and the hydroxy ester under thermal conditions. In addition to these results, other evidence indicated that the former reaction proceeds through an SN1-type mechanism, and the latter by an SN2-type mechanism. Two methods for the O-benzylation of carboxylic acids using TriBOT have been developed under either acidic or thermal conditions. The O-benzylation of hydroxy carboxylic acids afforded the dibenzylated product under acidic conditions and the hydroxy ester under thermal conditions. The former reaction proceeds through an SN1-type mechanism and the latter by an SN2-type mechanism.

Versatile and sustainable alcoholysis of amides by a reusable CeO 2 catalyst

CeO2 catalyzed the esterification between an equivalent molar ratio of primary amides and alcohols under neutral conditions, which provides the first versatile reusable catalytic system for direct alcoholysis of amides to esters with wider scope and 67 times higher turnover number (TON) than previous catalytic systems.

DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS

The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS

The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

TREATMENT OF METABOLIC SYNDROME WITH NOVEL AMIDES

The present invention relates to the treatment of metabolic syndrome or disorders associated with metabolic syndrome comprising administering a compound of the invention.

PENEM PRODRUGS

Orally bioavailable prodrugs of sulopenem, e.g., and solvates and hydrates thereof, preparation thereof, formulation thereof, and use to treat and prevent infection in mammals such as humans. This abstract is not limiting to the invention.

Synthesis of stable analogs in blood and conformational analysis of arenastatin A, a potent cytotoxic spongean depsipeptide

In order to produce stable analogs in blood of arenastatin A, a potent cytotoxic depsipeptide from the marine sponge Dysidea arenaria, we synthesized four analogs in which the 15-20 ester linkage was modified. Among them, the carba analog and 20-deoxo analog showed stability in serum. The conformation of arenastatin A and its three analogs were analyzed by distance-restrained molecular dynamic calculation to elucidate a three-dimensional stereostructure contributing to the extremely potent cytotoxicity of arenastatin A.

Synthesis and evaluation of hapalosin and analogs as MDR-reversing agents

The marine natural product hapalosin and 22 analogs, which incorporated systematic substituent deletions or variations, were prepared. These compounds were evaluated in a cell-based assay for both MDR-reversing activity and general cytotoxicity. Some substituent modifications resulted in lower cytotoxicities, but most structural changes were either detrimental to or did not seriously alter the MDR-reversing activity.

Substituted azetidinones as anti-inflammatory and antidegenerative agents

New substituted azetidinones of the general formula (I) which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described. STR1