195371-90-5Relevant articles and documents
Supported-Pd catalyzed tandem approach for N-arylbenzamides synthesis
Bhattacherjee, Dhananjay,Das, Pralay,Giri, Kousik,Shaifali,Sharma, Ajay Kumar,Sharma, Navneet,Sheetal
, (2021/11/24)
Aryl iodides as dual arylating agent for C-terminal from oxalic acid [(CO2H)2] and N-terminal from sodium azide (NaN3) for N-aryl benzamides (Ar-CO-NH-Ar) synthesis is a rare invention which has been attempted successfully under this study. A single step tandem approach for the synthesis of N-aryl benzamides has been developed through bifunctional transformation of aryl iodides with in-situ CO from (CO2H)2 and NaN3 following two different pathways of carbonylation and azidation. The polystyrene supported palladium (Pd@PS) catalyst was found to be well compatible to perform the domino-reaction in a double layer vial (DLV) system under base, ligand and additive-free conditions. Moreover, the same approach was further extended with aryl azides for unsymmetric N-aryl benzamides (Ar-CO-NH-Ar') synthesis. Furthermore, the DFT studies were also performed to support the proposed mechanism.
Amide Synthesis by Nickel/Photoredox-Catalyzed Direct Carbamoylation of (Hetero)Aryl Bromides
Alandini, Nurtalya,Buzzetti, Luca,Candish, Lisa,Collins, Karl D.,Favi, Gianfranco,Melchiorre, Paolo,Schulte, Tim
supporting information, p. 5248 - 5253 (2020/03/03)
Herein, we report a one-electron strategy for catalytic amide synthesis that enables the direct carbamoylation of (hetero)aryl bromides. This radical cross-coupling approach, which is based on the combination of nickel and photoredox catalysis, proceeds at ambient temperature and uses readily available dihydropyridines as precursors of carbamoyl radicals. The method's mild reaction conditions make it tolerant of sensitive-functional-group-containing substrates and allow the installation of an amide scaffold within biologically relevant heterocycles. In addition, we installed amide functionalities bearing electron-poor and sterically hindered amine moieties, which would be difficult to prepare with classical dehydrative condensation methods.
Amide compound with antitumor activity and application of amide compound
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Paragraph 0141; 0142; 0143; 0144; 0145, (2017/08/02)
The invention belongs to the technical field of pharmaceutical chemistry and particularly provides an amide compound with antitumor activity and application of the amide compound. The structural formula of the amide compound is shown as R1CONHR2, wherein R1 and R2 are independently selected from aryl or heterocycle. The biological activity test result of the compound shows that the compound has a good inhibition effect on histone methyl SET7. Good antitumor aspect development application prospects are achieved.
A kind of orange light iridium complex and its in organic whitening or orange light in the device of the application
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Paragraph 0050; 0052, (2017/02/23)
The invention discloses organic optical iridium coordination compounds and application thereof in an organic electro-generated white or orange optical device. The orange optical iridium coordinate compounds have a structural formula as formula 1 or formul
Small molecule fluoride toxicity agonists
Nelson, James W.,Plummer, Mark S.,Blount, Kenneth F.,Ames, Tyler D.,Breaker, Ronald R.
, p. 527 - 534 (2015/05/05)
Fluoride is a ubiquitous anion that inhibits a wide variety of metabolic processes. Here, we report the identification of a series of compounds that enhance fluoride toxicity in Escherichia coli and Streptococcus mutans. These molecules were isolated by u
Experimental and computational insights into the nature of weak intermolecular interactions in trifluoromethyl-substituted isomeric crystalline N-methyl-N-phenylbenzamides
Panini, Piyush,Chopra, Deepak
, p. 8720 - 8738 (2015/11/10)
The knowledge about the prevalence of weak interactions in terms of the nature and energetics associated with their formation is of significance in organic solids. In the present study, we have systematically explored the existence of different types of i
Obtaining highly efficient single-emissive-layer orange and two-element white organic light-emitting diodes by the solution process
Wang, Jinshan,Xu, Xinjun,Tian, Yuan,Yao, Chuang,Li, Lidong
, p. 5036 - 5045 (2014/06/24)
By attaching two electron-withdrawing trifluoromethyl (CF3) groups to the 2-phenylbenzothiazole cyclo-metalated ligand, a bis-trifluoromethyl-functionalized orange-emitting phosphorescent iridium(iii) complex bis-(6-(trifluoromethyl)-2-(4-(trif
Role of intermolecular interactions involving organic fluorine in trifluoromethylated benzanilides
Panini, Piyush,Chopra, Deepak
experimental part, p. 1972 - 1989 (2012/05/21)
Trifluoromethylated benzanilides, containing C(sp3)-F bonds, have been synthesized and their crystal and molecular structures have been investigated to highlight the significance of weak intermolecular interactions associated with the presence
Convenient palladium-catalyzed aminocarbonylation of anilines to N-arylbenzamides
Wu, Xiao-Feng,Schranck, Johannes,Neumann, Helfried,Beller, Matthias
experimental part, p. 3702 - 3704 (2011/08/06)
The first one-pot diazotization/aminocarbonylation reaction of anilines to benzamides has been developed. In the presence of commercially available palladium acetate/P(o-Tolyl)3 as the catalyst system without base at low temperature (50°C) a variety of amides were synthesized in moderate to good yields.
