197093-23-5

Basic information

• Product Name: [3-(1H-Pyrazol-3-yl)-phenyl]-Methanol
• Synonyms: [3-(1H-Pyrazol-3-yl)-phenyl]-Methanol
• CAS NO: 197093-23-5
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.1992
• Mol File: 197093-23-5.mol

Chemical Properties

• Melting Point: 92.7-94.7 °C
• Boiling Point: 419.9±25.0 °C(Predicted)
• Appearance: /
• Density: 1.243±0.06 g/cm3(Predicted)
• PKA: 13.37±0.10(Predicted)
• CAS DataBase Reference: [3-(1H-Pyrazol-3-yl)-phenyl]-Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [3-(1H-Pyrazol-3-yl)-phenyl]-Methanol(197093-23-5)
• EPA Substance Registry System: [3-(1H-Pyrazol-3-yl)-phenyl]-Methanol(197093-23-5)

Safety Data

• Hazardous Substances Data: 197093-23-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
[3-(1H-Pyrazol-3-yl)-phenyl]-Methanol is used as a building block or intermediate for the synthesis of pharmaceutical compounds due to its unique molecular structure and reactivity. Its ability to be incorporated into the development of new drugs makes it a valuable asset in medicinal chemistry.
Used in Research and Development:
In the realm of research and development, [3-(1H-Pyrazol-3-yl)-phenyl]-Methanol is utilized as a key component in the creation of new organic chemicals. Its versatility in chemical reactions allows for the exploration of novel chemical pathways and the discovery of innovative applications.
Used in Medicinal Chemistry and Drug Discovery:
[3-(1H-Pyrazol-3-yl)-phenyl]-Methanol is employed as a reagent in medicinal chemistry and drug discovery processes. Its role in introducing the 1H-pyrazol-3-yl functional group into molecules contributes to the development of new therapeutic agents and the enhancement of existing ones.
Used in Organic Chemical Reactions:
As a reagent in organic chemical reactions, [3-(1H-Pyrazol-3-yl)-phenyl]-Methanol is used to introduce the 1H-pyrazol-3-yl functional group into various molecules. This capability broadens the scope of chemical modifications and the synthesis of new compounds with potential applications in various industries.

Upstream product

• 99769-19-4 [3-(methoxycarbonyl)phenyl]boronic acid 
• 57455-06-8 3-iodobenzylalcohol 
• 197093-16-6 N-tosyl-N-propargylhydrazine 

Downstream Products

• 676557-81-6 ethanethioic acid S-[[3-(1H-pyrazol-3-yl)phenyl]methyl] ester 
• 676557-86-1 3,3',3-[methylidynetris(1H-pyrazole-1,3-diyl)]tribenzene-methane thiol 
• 676557-82-7 3-(1H-pyrazol-3-yl)benzenemethanethiol 

Relevant articles and documents

PIKFYVE KINASE INHIBITORS

The present invention relates to compounds useful as inhibitors of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) as well as their use for treating diseases and disorders associated with PIKfyve.

Versatility and dynamics of the copper(I) coordination sphere in sterically hindering tris(pyrazolyl)methane-incorporating macrobicycles

Two arene-capped macrobicycles (1 and 2) incorporating the tris(pyrazolyl)methane (Tpm) chelate have been prepared from a benzylthiol-functionalized Tpm precursor (3). Reaction of either macrobicycle with Cu(CH3CN)4+ leads

Synthesis of a macrobicycle incorporating the tris(pyrazolyl)methane ligand

Steric crowding of the 3-position of tris(pyrazolyl)borate and -methane ligands has produced tetrahedral metal complexes with controlled reactivity. As an alternative, we propose to incorporate the tris(pyrazolyl)methane chelate in a macrobicyclic structu

Functionalised Pyrazoles through a Facile One-Pot Procedure from N-Tosyl-N-propargylhydrazine and Aryl Iodides or Vinyl Triflates

Functionalised pyrazoles have been prepared in good overall yield through a facile one-pot procedure. The synthesis includes the palladium-catalysed coupling of the readily available N-tosyl-N-propargylhydrazine with aryl iodides or vinyl triflates, the palladium-catalysed annulation of the resulting N-tosyl-N-(1-aryl/vinyl-1-propyn3-yl)hydrazine and exposure of the reaction mixture arising from the annulation step to KOBut.