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(5-Bromo-2,3-dihydrobenzofuran-2-yl)methanol, with the chemical formula C9H9BrO2, is a white crystalline solid belonging to the benzofuran derivatives class. It has a molecular weight of 227.07 g/mol and is primarily used as an intermediate in the synthesis of pharmaceuticals and other organic compounds.

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  • 197577-35-8 Structure
  • Basic information

    1. Product Name: (5-BroMo-2,3-dihydrobenzofuran-2-yl)Methanol
    2. Synonyms: (5-BroMo-2,3-dihydrobenzofuran-2-yl)Methanol;5-Bromo-2,3-dihydro-1-benzofuran-2-carboxylic acid;5-bromo-2,3-dihydro-2-benzofuranmethanol;2-BENZOFURANMETHANOL, 5-BROMO-2,3-DIHYDRO-;2-Benzofuranmethanol, 5-Bromo-2,3-Dihydro-(WX640105)
    3. CAS NO:197577-35-8
    4. Molecular Formula: C9H9BrO2
    5. Molecular Weight: 229.07056
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 197577-35-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (5-BroMo-2,3-dihydrobenzofuran-2-yl)Methanol(CAS DataBase Reference)
    10. NIST Chemistry Reference: (5-BroMo-2,3-dihydrobenzofuran-2-yl)Methanol(197577-35-8)
    11. EPA Substance Registry System: (5-BroMo-2,3-dihydrobenzofuran-2-yl)Methanol(197577-35-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 197577-35-8(Hazardous Substances Data)

197577-35-8 Usage

Uses

Used in Pharmaceutical Industry:
(5-Bromo-2,3-dihydrobenzofuran-2-yl)methanol is used as an intermediate in the synthesis of various pharmaceuticals for its potential applications in the development of drugs for different therapeutic purposes.
Used in Organic Synthesis and Research:
(5-Bromo-2,3-dihydrobenzofuran-2-yl)methanol is also used in the field of organic synthesis and research for its potential applications in creating new organic compounds and contributing to scientific advancements.

Check Digit Verification of cas no

The CAS Registry Mumber 197577-35-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,7,5,7 and 7 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 197577-35:
(8*1)+(7*9)+(6*7)+(5*5)+(4*7)+(3*7)+(2*3)+(1*5)=198
198 % 10 = 8
So 197577-35-8 is a valid CAS Registry Number.

197577-35-8Upstream product

197577-35-8Relevant articles and documents

Azidosubstituted arylboronic acids: Synthesis and Suzuki-Miyaura cross-coupling reactions

Sviridov, Sergey I.,Vasil'ev, Andrei A.,Sergovskaya, Natalia L.,Chirskaya, Marina V.,Shorshnev, Sergey V.

, p. 2639 - 2647 (2007/10/03)

Arylboronic acids having a remote azido group were prepared from the corresponding azidosubstituted aryl bromides via lithiation and treatment with trialkyl borates. Preparative yields were achieved when the starting aryl bromides possessed ortho-alkoxy groups, which would stabilize the intermediate aryllithium species. Conventional Suzuki cross-coupling of the arylboronic acids proceeded generally well with retention of azido group; however, sometimes azidomethyl fragment underwent oxidative transformation into a nitrile.

Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists

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Page/Page column 16, (2008/06/13)

Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, furanyl, thienyl, pyridyl, pyridyl N-oxide, oxazolyl or pyrrolyl, or cycloalkenyl R1, R2, R3, R4 and R5 are H, alkyl or alkoxyalkyl; and Z is optionally substituted aryl or heteroaryl are disclosed. Also disclosed is the use of compounds of formula I in the treatment of central nervous system diseases, in particular Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, and pharmaceutical compositions comprising them.

Benzofuran and dihydrobenzofuran derivatives useful as beta-3 adrenoreceptor agonists

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Page/Page column 33, (2010/01/31)

This invention relates to novel benzofuran and dihydrobenzofuran compounds, pharmaceutical compositions containing such compounds, and methods of treating beta-3 adrenoreceptor-mediated conditions with such compositions.

α-Adrenoreceptor Reagents. 2. Effects of Modification of the 1,4-Benzodioxan Ring System on α-Adrenoreceptor Activity

Chapleo, Christopher B.,Myers, Peter L.,Butler, Richard C. M.,Davis, John A.,Doxey, John C.,et al.

, p. 570 - 576 (2007/10/02)

Modification of the 1,4-benzodioxan ring present in RX 781094 (1) has not previously been considered.This paper describes a number of analogues of this ring system, including compounds in which one of the oxygen atoms has been replaced by a methylene group and also those in which the ring size has been changed to give, for example, furan and thiophene derivatives.The dihydroxybenzofuranylimidazoline compound 7 is the only analogue possesing presynaptic antagonist potency and selectivity comparable to that of 1.In view of this result, a number of derivatives was prepared to determine the structure-activity relationships within this series.Many derivatives, as well as the parent compound 7, were found to possess presynaptic α2-adrenoreceptor antagonist and postsynaptic α1-adrenoreceptor partial agonist properties.Two of the selective presynaptic antagonists,13 and 14, possess greater potency and selectivity than that possessed by 1.The 5-chloro derivative 25 is twice as potent as 1 after oral administration but only about half as potent when given intravenously.

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