197723-00-5Relevant articles and documents
MANUFACTURE OF TRANS-[TETRACHLOROBIS(1H-INDAZOLE)RUTHENATE (III)] AND COMPOSITIONS THEREOF
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Paragraph 0355-0357, (2018/12/04)
The present invention relates to the preparation of compositions comprising sodium trans-[tetrachlorobis(1H-indazole)ruthenate (III)]. Synthesis and formulation preparation is detailed. Impurity profiles are also discussed. Compositions herein are useful for anti-cancer applications.
METHOD OF MANUFACTURING A RUTHENIUM COMPLEX
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Page/Page column 7, (2009/01/24)
A method of making an alkali metal salt of trans-[tetrachlorobis(1H-indazole)ruthenate (III)] is disclosed.
Synthesis of tumor-inhibiting complex salts containing the anion trans- tetrachlorobis(indazole)ruthenate(III) and crystal structure of the tetraphenylphosphonium salt
Peti, Wolfgang,Pieper, Thomas,Sommer, Martina,Keppler, Bernhard K.,Giester, Gerald
, p. 1551 - 1555 (2007/10/03)
Indazolium trans-tetrachlorobis(indazole)ruthenate(III) exhibits excellent results against different tumor models in retro and in vivo. To improve the water solubility necessary for the introduction of this tumor- inhibiting compound into clinical trials, we synthesized the corresponding sodium salt in a two-step ion exchange via the tetramethylammonium salt. The sodium salt shows a 35-fold higher solubility in water relative to the indazolium salt. We also synthesized the n-butylammonium, n-octylammonium, and tetraphenyl-phosphonium salts, all of which showed unproved solubility in organic solvents. The X-ray crystal structure of the latter could be solved, proving the trans configuration of the complex anion. In spite of the paramagnetic Ru111 center an assignment of the coordinated indazole protons could be made with the help of a COSY experiment.
